Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel
Abstract Omega 3 polyunsaturated fatty acids (PUFAs) influence metabolism and thermogenesis in non-hibernators. How omega 3 PUFAs influence Arctic Ground Squirrels (AGS) during hibernation is unknown. Prior to hibernation we fed AGS chow composed of an omega 6:3 ratio approximately 1:1 (high in omeg...
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ftdoajarticles:oai:doaj.org/article:16a6e30838bf46f0b6f8290857fdbda7 2023-05-15T14:31:29+02:00 Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew 2021-01-01T00:00:00Z https://doi.org/10.1038/s41598-020-78763-8 https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda7 EN eng Nature Portfolio https://doi.org/10.1038/s41598-020-78763-8 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-020-78763-8 2045-2322 https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda7 Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) Medicine R Science Q article 2021 ftdoajarticles https://doi.org/10.1038/s41598-020-78763-8 2022-12-31T05:22:49Z Abstract Omega 3 polyunsaturated fatty acids (PUFAs) influence metabolism and thermogenesis in non-hibernators. How omega 3 PUFAs influence Arctic Ground Squirrels (AGS) during hibernation is unknown. Prior to hibernation we fed AGS chow composed of an omega 6:3 ratio approximately 1:1 (high in omega 3 PUFA, termed Balanced Diet), or an omega 6:3 ratio of 5:1 (Standard Rodent Chow), and measured the influence of diet on core body temperature (Tb), brown adipose tissue (BAT) mass, fatty acid profiles of BAT, white adipose tissue (WAT) and plasma as well as hypothalamic endocannabinoid and endocannabinoid-like bioactive fatty acid amides during hibernation. Results show feeding a diet high in omega 3 PUFAs, with a more balanced omega 6:3 ratio, increases AGS Tb in torpor. We found the diet-induced increase in Tb during torpor is most easily explained by an increase in the mass of BAT deposits of Balanced Diet AGS. The increase in BAT mass is associated with elevated levels of metabolites DHA and EPA in tissue and plasma suggesting that these omega 3 PUFAs may play a role in thermogenesis during torpor. While we did not observe diet-induced change in endocannabinoids, we do report altered hypothalamic levels of some endocannabinoids, and endocannabinoid-like compounds, during hibernation. Article in Journal/Newspaper Arctic ground squirrel Arctic Directory of Open Access Journals: DOAJ Articles Arctic Scientific Reports 11 1 |
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Medicine R Science Q S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel |
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Medicine R Science Q |
description |
Abstract Omega 3 polyunsaturated fatty acids (PUFAs) influence metabolism and thermogenesis in non-hibernators. How omega 3 PUFAs influence Arctic Ground Squirrels (AGS) during hibernation is unknown. Prior to hibernation we fed AGS chow composed of an omega 6:3 ratio approximately 1:1 (high in omega 3 PUFA, termed Balanced Diet), or an omega 6:3 ratio of 5:1 (Standard Rodent Chow), and measured the influence of diet on core body temperature (Tb), brown adipose tissue (BAT) mass, fatty acid profiles of BAT, white adipose tissue (WAT) and plasma as well as hypothalamic endocannabinoid and endocannabinoid-like bioactive fatty acid amides during hibernation. Results show feeding a diet high in omega 3 PUFAs, with a more balanced omega 6:3 ratio, increases AGS Tb in torpor. We found the diet-induced increase in Tb during torpor is most easily explained by an increase in the mass of BAT deposits of Balanced Diet AGS. The increase in BAT mass is associated with elevated levels of metabolites DHA and EPA in tissue and plasma suggesting that these omega 3 PUFAs may play a role in thermogenesis during torpor. While we did not observe diet-induced change in endocannabinoids, we do report altered hypothalamic levels of some endocannabinoids, and endocannabinoid-like compounds, during hibernation. |
format |
Article in Journal/Newspaper |
author |
S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew |
author_facet |
S. A. Rice M. Mikes D. Bibus E. Berdyshev J. A. Reisz S. Gehrke I. Bronova A. D’Alessandro K. L. Drew |
author_sort |
S. A. Rice |
title |
Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel |
title_short |
Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel |
title_full |
Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel |
title_fullStr |
Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel |
title_full_unstemmed |
Omega 3 fatty acids stimulate thermogenesis during torpor in the Arctic Ground Squirrel |
title_sort |
omega 3 fatty acids stimulate thermogenesis during torpor in the arctic ground squirrel |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doi.org/10.1038/s41598-020-78763-8 https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic ground squirrel Arctic |
genre_facet |
Arctic ground squirrel Arctic |
op_source |
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
op_relation |
https://doi.org/10.1038/s41598-020-78763-8 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-020-78763-8 2045-2322 https://doaj.org/article/16a6e30838bf46f0b6f8290857fdbda7 |
op_doi |
https://doi.org/10.1038/s41598-020-78763-8 |
container_title |
Scientific Reports |
container_volume |
11 |
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1 |
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1766305106401165312 |