Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos
Os autores relatam a resposta terapêutica da claritromicina associada com pirímetamina em dois casos de toxoplasmose cerebral ocorridos em pacientes com Síndrome de Imunodeficiência Adquirida (SIDA). Nos dois casos o diagnóstico foi presuntivo, baseando-se nas manifestações clínicas e na presença de...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1995
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ftdoajarticles:oai:doaj.org/article:16a38e63ac6240dc8334d30445d2e0e7 2023-05-15T15:12:09+02:00 Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos Marcos Olivicr Dalston Walter Tavares Ana Ricordi Bazin Miriam Dumas Ilahn Alair Augusto S. Damas dos Santos Teimo Pimentel Jurema Nunes Mello 1995-12-01T00:00:00Z https://doaj.org/article/16a38e63ac6240dc8334d30445d2e0e7 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000400016 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/16a38e63ac6240dc8334d30445d2e0e7 Revista da Sociedade Brasileira de Medicina Tropical, Vol 28, Iss 4, Pp 409-413 (1995) Claritromicina Toxoplasmose cerebral SIDA Clarithromycin Cerebral toxoplasmosis AIDS Arctic medicine. Tropical medicine RC955-962 article 1995 ftdoajarticles 2022-12-30T21:37:16Z Os autores relatam a resposta terapêutica da claritromicina associada com pirímetamina em dois casos de toxoplasmose cerebral ocorridos em pacientes com Síndrome de Imunodeficiência Adquirida (SIDA). Nos dois casos o diagnóstico foi presuntivo, baseando-se nas manifestações clínicas e na presença de lesões expansivas hipercaptantes detectadas na tomografia computadorizada (TC) de crânio. Em ambos os casos, observou-se exantema com o uso da sulfadiazina e da clindamicina, razão pela qual tais medicamentos foram substituídos pela claritromicina (1,5 a 2g/dia) associada à pirímetamina (25mg/dia). A resposta terapêutica foi favorável nos dois casos com melhora das manifestações neurológicas e dos achados neurorradiológicos. Os autores sugerem que a associação claritromicina com pirímetamina pode ser útil como opção terapêutica na toxoplasmose cerebral em pacientes com SIDA que apresentam intolerância ou outra contra-indicação ao emprego das sulfonamidas. The authors report the use and tbe outcome of claritromycin associated with pyrimethamine in the treatment of toxoplasma encephalites in two patients with AIDS. Both patients had the diagnosis stablished on clinical grounds, positive sorology (IgG) for toxoplasmosis and computed-tomographic (CT) scan of the brain showing lesions consistent with T. gondii encephalitis. The two patients were initially treated with pyrimethamine and sulfadiazme, which was changed to clindamycin due to allergic reactions. These reactions (skin rash) occurred with clindamycin as well and the patients were treated with claritromycin and pyrimethamine. The scheduled regimens were 1.5 to 2g of clarithromycin plus 25mg of pyrimethamine. The clinical response was very good in both cases with regression of neurologic signs and encephalitic abnormalities observed on CT scan. The authors suggest that clarithromycin associated with pyrimethamine may be an alternative treatment for toxoplasmosis in AIDS patients, who cannot receive or tolerate sulfa treatment. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sida ENVELOPE(101.683,101.683,67.800,67.800) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Claritromicina Toxoplasmose cerebral SIDA Clarithromycin Cerebral toxoplasmosis AIDS Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Claritromicina Toxoplasmose cerebral SIDA Clarithromycin Cerebral toxoplasmosis AIDS Arctic medicine. Tropical medicine RC955-962 Marcos Olivicr Dalston Walter Tavares Ana Ricordi Bazin Miriam Dumas Ilahn Alair Augusto S. Damas dos Santos Teimo Pimentel Jurema Nunes Mello Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
topic_facet |
Claritromicina Toxoplasmose cerebral SIDA Clarithromycin Cerebral toxoplasmosis AIDS Arctic medicine. Tropical medicine RC955-962 |
description |
Os autores relatam a resposta terapêutica da claritromicina associada com pirímetamina em dois casos de toxoplasmose cerebral ocorridos em pacientes com Síndrome de Imunodeficiência Adquirida (SIDA). Nos dois casos o diagnóstico foi presuntivo, baseando-se nas manifestações clínicas e na presença de lesões expansivas hipercaptantes detectadas na tomografia computadorizada (TC) de crânio. Em ambos os casos, observou-se exantema com o uso da sulfadiazina e da clindamicina, razão pela qual tais medicamentos foram substituídos pela claritromicina (1,5 a 2g/dia) associada à pirímetamina (25mg/dia). A resposta terapêutica foi favorável nos dois casos com melhora das manifestações neurológicas e dos achados neurorradiológicos. Os autores sugerem que a associação claritromicina com pirímetamina pode ser útil como opção terapêutica na toxoplasmose cerebral em pacientes com SIDA que apresentam intolerância ou outra contra-indicação ao emprego das sulfonamidas. The authors report the use and tbe outcome of claritromycin associated with pyrimethamine in the treatment of toxoplasma encephalites in two patients with AIDS. Both patients had the diagnosis stablished on clinical grounds, positive sorology (IgG) for toxoplasmosis and computed-tomographic (CT) scan of the brain showing lesions consistent with T. gondii encephalitis. The two patients were initially treated with pyrimethamine and sulfadiazme, which was changed to clindamycin due to allergic reactions. These reactions (skin rash) occurred with clindamycin as well and the patients were treated with claritromycin and pyrimethamine. The scheduled regimens were 1.5 to 2g of clarithromycin plus 25mg of pyrimethamine. The clinical response was very good in both cases with regression of neurologic signs and encephalitic abnormalities observed on CT scan. The authors suggest that clarithromycin associated with pyrimethamine may be an alternative treatment for toxoplasmosis in AIDS patients, who cannot receive or tolerate sulfa treatment. |
format |
Article in Journal/Newspaper |
author |
Marcos Olivicr Dalston Walter Tavares Ana Ricordi Bazin Miriam Dumas Ilahn Alair Augusto S. Damas dos Santos Teimo Pimentel Jurema Nunes Mello |
author_facet |
Marcos Olivicr Dalston Walter Tavares Ana Ricordi Bazin Miriam Dumas Ilahn Alair Augusto S. Damas dos Santos Teimo Pimentel Jurema Nunes Mello |
author_sort |
Marcos Olivicr Dalston |
title |
Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
title_short |
Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
title_full |
Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
title_fullStr |
Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
title_full_unstemmed |
Claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
title_sort |
claritromicina associada com pirímetamina na toxoplasmose cerebral - relato de dois casos |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1995 |
url |
https://doaj.org/article/16a38e63ac6240dc8334d30445d2e0e7 |
long_lat |
ENVELOPE(101.683,101.683,67.800,67.800) |
geographic |
Arctic Sida |
geographic_facet |
Arctic Sida |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 28, Iss 4, Pp 409-413 (1995) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821995000400016 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/16a38e63ac6240dc8334d30445d2e0e7 |
_version_ |
1766342867573276672 |