Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya.
BACKGROUND:Cutaneous leishmaniasis (CL) is a major public health problem in Libya. In this paper, we describe the eco-epidemiological parameters of CL during the armed conflict period from January 2011 till December 2012. Current spatiotemporal distributions of CL cases were explored and projected t...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0005873 https://doaj.org/article/15ed8161bc99469c98e013b550fe13ba |
id |
ftdoajarticles:oai:doaj.org/article:15ed8161bc99469c98e013b550fe13ba |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:15ed8161bc99469c98e013b550fe13ba 2023-05-15T15:15:14+02:00 Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. Ahmad Amro Hamida Al-Dwibe Aisha Gashout Olga Moskalenko Marlena Galafin Omar Hamarsheh Marcus Frohme Anja Jaeschke Gabriele Schönian Katrin Kuhls 2017-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005873 https://doaj.org/article/15ed8161bc99469c98e013b550fe13ba EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5605087?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005873 https://doaj.org/article/15ed8161bc99469c98e013b550fe13ba PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005873 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005873 2022-12-31T10:28:36Z BACKGROUND:Cutaneous leishmaniasis (CL) is a major public health problem in Libya. In this paper, we describe the eco-epidemiological parameters of CL during the armed conflict period from January 2011 till December 2012. Current spatiotemporal distributions of CL cases were explored and projected to the future using a correlative modelling approach. In addition the present results were compared with our previous data obtained for the time period 1995-2008. METHODOLOGY/PRINCIPAL FINDINGS:We investigated 312 CL patients who presented to the Dermatology Department at the Tripoli Central Hospital and came from 81 endemic areas distributed in 10 districts. The patients presented with typical localized lesions which appeared commonly on the face, arms and legs. Molecular identification of parasites by a PCR-RFLP approach targeting the ITS1 region of the rDNA was successful for 81 patients with two causative species identified: L. major and L. tropica comprised 59 (72.8%) and 22 (27.2%) cases, respectively. Around 77.3% of L. tropica CL and 57.7% of L. major CL caused single lesions. Five CL patients among our data set were seropositive for HIV. L. tropica was found mainly in three districts, Murqub (27.3%), Jabal al Gharbi (27.3%) and Misrata (13.7%) while L. major was found in two districts, in Jabal al Gharbi (61%) and Jafara (20.3%). Seasonal occurrence of CL cases showed that most cases (74.2%) admitted to the hospital between November and March, L. major cases from November till January (69.4%), and L. tropica cases mainly in January and February (41%). Two risk factors were identified for the two species; the presence of previously infected household members, and the presence of rodents and sandflies in patient's neighborhoods. Spatiotemporal projections using correlative distribution models based on current case data and climatic conditions showed that coastal regions have a higher level of risk due to more favourable conditions for the transmitting vectors. CONCLUSION:Future projection of CL until 2060 showed ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 9 e0005873 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ahmad Amro Hamida Al-Dwibe Aisha Gashout Olga Moskalenko Marlena Galafin Omar Hamarsheh Marcus Frohme Anja Jaeschke Gabriele Schönian Katrin Kuhls Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Cutaneous leishmaniasis (CL) is a major public health problem in Libya. In this paper, we describe the eco-epidemiological parameters of CL during the armed conflict period from January 2011 till December 2012. Current spatiotemporal distributions of CL cases were explored and projected to the future using a correlative modelling approach. In addition the present results were compared with our previous data obtained for the time period 1995-2008. METHODOLOGY/PRINCIPAL FINDINGS:We investigated 312 CL patients who presented to the Dermatology Department at the Tripoli Central Hospital and came from 81 endemic areas distributed in 10 districts. The patients presented with typical localized lesions which appeared commonly on the face, arms and legs. Molecular identification of parasites by a PCR-RFLP approach targeting the ITS1 region of the rDNA was successful for 81 patients with two causative species identified: L. major and L. tropica comprised 59 (72.8%) and 22 (27.2%) cases, respectively. Around 77.3% of L. tropica CL and 57.7% of L. major CL caused single lesions. Five CL patients among our data set were seropositive for HIV. L. tropica was found mainly in three districts, Murqub (27.3%), Jabal al Gharbi (27.3%) and Misrata (13.7%) while L. major was found in two districts, in Jabal al Gharbi (61%) and Jafara (20.3%). Seasonal occurrence of CL cases showed that most cases (74.2%) admitted to the hospital between November and March, L. major cases from November till January (69.4%), and L. tropica cases mainly in January and February (41%). Two risk factors were identified for the two species; the presence of previously infected household members, and the presence of rodents and sandflies in patient's neighborhoods. Spatiotemporal projections using correlative distribution models based on current case data and climatic conditions showed that coastal regions have a higher level of risk due to more favourable conditions for the transmitting vectors. CONCLUSION:Future projection of CL until 2060 showed ... |
format |
Article in Journal/Newspaper |
author |
Ahmad Amro Hamida Al-Dwibe Aisha Gashout Olga Moskalenko Marlena Galafin Omar Hamarsheh Marcus Frohme Anja Jaeschke Gabriele Schönian Katrin Kuhls |
author_facet |
Ahmad Amro Hamida Al-Dwibe Aisha Gashout Olga Moskalenko Marlena Galafin Omar Hamarsheh Marcus Frohme Anja Jaeschke Gabriele Schönian Katrin Kuhls |
author_sort |
Ahmad Amro |
title |
Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. |
title_short |
Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. |
title_full |
Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. |
title_fullStr |
Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. |
title_full_unstemmed |
Spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in Libya. |
title_sort |
spatiotemporal and molecular epidemiology of cutaneous leishmaniasis in libya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005873 https://doaj.org/article/15ed8161bc99469c98e013b550fe13ba |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005873 (2017) |
op_relation |
http://europepmc.org/articles/PMC5605087?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005873 https://doaj.org/article/15ed8161bc99469c98e013b550fe13ba |
op_doi |
https://doi.org/10.1371/journal.pntd.0005873 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
9 |
container_start_page |
e0005873 |
_version_ |
1766345600149749760 |