Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study

• Published in: Asian Pacific Journal of Tropical Medicine
• Main Authors: Sha Xiao, Wen-fang Long, Yi-jiang Huang, Shi-cheng Kuang, Chong Meng, Yun-ru Liu, Yu-mei Liu, Zhen Yan, De-e Yu, Fan Zhang
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018
• Subjects: XPB; XPD; XPG; SNP; Lung cancer; Arctic medicine. Tropical medicine; RC955-962; Arctic; Ner
• Online Access: https://doi.org/10.4103/1995-7645.243105; https://doaj.org/article/15e0553bcb364fcea283d4ec6b968639

Objective: The transcription factor IIH (TFIIH) helicases XPB and XPD are responsible for opening the DNA strand around the lesion site and endonuclease XPG cleaves the damaged DNA strand on the 3’ side during nucleotide excision repair (NER). Polymorphisms in these three genes that affect DNA repai...