Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study
Objective: The transcription factor IIH (TFIIH) helicases XPB and XPD are responsible for opening the DNA strand around the lesion site and endonuclease XPG cleaves the damaged DNA strand on the 3’ side during nucleotide excision repair (NER). Polymorphisms in these three genes that affect DNA repai...
Published in: | Asian Pacific Journal of Tropical Medicine |
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Language: | English |
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Wolters Kluwer Medknow Publications
2018
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Online Access: | https://doi.org/10.4103/1995-7645.243105 https://doaj.org/article/15e0553bcb364fcea283d4ec6b968639 |
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ftdoajarticles:oai:doaj.org/article:15e0553bcb364fcea283d4ec6b968639 2023-05-15T15:17:17+02:00 Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study Sha Xiao Wen-fang Long Yi-jiang Huang Shi-cheng Kuang Chong Meng Yun-ru Liu Yu-mei Liu Zhen Yan De-e Yu Fan Zhang 2018-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.243105 https://doaj.org/article/15e0553bcb364fcea283d4ec6b968639 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=13;spage=37;epage=37;aulast=Xiao https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.243105 https://doaj.org/article/15e0553bcb364fcea283d4ec6b968639 Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 13, Pp 37-37 (2018) XPB XPD XPG SNP Lung cancer Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.4103/1995-7645.243105 2022-12-31T02:10:25Z Objective: The transcription factor IIH (TFIIH) helicases XPB and XPD are responsible for opening the DNA strand around the lesion site and endonuclease XPG cleaves the damaged DNA strand on the 3’ side during nucleotide excision repair (NER). Polymorphisms in these three genes that affect DNA repair capacity may contribute to susceptibility of lung cancer. In this study, our objective is to conduct a case-control study of 100 Chinese patients with lung cancer and 100 cancer-free age and sex matched controls to analyse associations between these SNPs and lung cancer susceptibility. Methods: In this hospital-based case-control study, we genotyped 7 SNPs of XPB, XPD and XPG using matrix assisted laser desorption ionisation-time of flight mass spectrometry method (MALDI-TOF) to explore the association with lung cancer risk. To estimate the relative risk of lung cancer associated with SNP genotype, odds ratios (OR) and 95.0% confidence intervals (95.0% CI) were obtained from unconditional multinomial logistic regression models without and with adjustment for potential confounders including age, gender, cigarette smoking and alcohol consumption. Results: The results showed that individuals carrying XPB rs4150434 GA or AA genotype (OR per GA genotype, 1.997; 95.0% CI: 1.031-3.871; P=0.039; OR per AA genotype, 2.435; 95.0% CI: 1.037-5.718; P=0.037), and this association was also find in nondrinkers (OR per GA genotype, 2.477; 95.0% CI: 1.128-5.440; P=0.022). Individuals carrying XPG rs2094258 AA genotype had an increased risk of lung cancer (OR per AA genotype, 3.020; 95.0% CI: 1.015-8.980; P=0.040) compared with individuals with the GG genotype, especially in nondrinkers (OR per AA genotype, 4.020; 95.0% CI: 1.211-13.339; P=0.017). In addition, we found that XPG rs17655 CG or GG genotype associated with decreased lung cancer risk in drinkers (OR per XPG rs17655 CG genotype, 0.238; 95.0% CI: 0.061~0.925; P=0.034; OR per XPG rs17655 GG genotype, 0.l39; 95.0% CI: 0.021-0.938; P=0.032). Haplotype analysis of all 7 SNPs ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Ner ENVELOPE(6.622,6.622,62.612,62.612) Asian Pacific Journal of Tropical Medicine 11 13 37 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
XPB XPD XPG SNP Lung cancer Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
XPB XPD XPG SNP Lung cancer Arctic medicine. Tropical medicine RC955-962 Sha Xiao Wen-fang Long Yi-jiang Huang Shi-cheng Kuang Chong Meng Yun-ru Liu Yu-mei Liu Zhen Yan De-e Yu Fan Zhang Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study |
topic_facet |
XPB XPD XPG SNP Lung cancer Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: The transcription factor IIH (TFIIH) helicases XPB and XPD are responsible for opening the DNA strand around the lesion site and endonuclease XPG cleaves the damaged DNA strand on the 3’ side during nucleotide excision repair (NER). Polymorphisms in these three genes that affect DNA repair capacity may contribute to susceptibility of lung cancer. In this study, our objective is to conduct a case-control study of 100 Chinese patients with lung cancer and 100 cancer-free age and sex matched controls to analyse associations between these SNPs and lung cancer susceptibility. Methods: In this hospital-based case-control study, we genotyped 7 SNPs of XPB, XPD and XPG using matrix assisted laser desorption ionisation-time of flight mass spectrometry method (MALDI-TOF) to explore the association with lung cancer risk. To estimate the relative risk of lung cancer associated with SNP genotype, odds ratios (OR) and 95.0% confidence intervals (95.0% CI) were obtained from unconditional multinomial logistic regression models without and with adjustment for potential confounders including age, gender, cigarette smoking and alcohol consumption. Results: The results showed that individuals carrying XPB rs4150434 GA or AA genotype (OR per GA genotype, 1.997; 95.0% CI: 1.031-3.871; P=0.039; OR per AA genotype, 2.435; 95.0% CI: 1.037-5.718; P=0.037), and this association was also find in nondrinkers (OR per GA genotype, 2.477; 95.0% CI: 1.128-5.440; P=0.022). Individuals carrying XPG rs2094258 AA genotype had an increased risk of lung cancer (OR per AA genotype, 3.020; 95.0% CI: 1.015-8.980; P=0.040) compared with individuals with the GG genotype, especially in nondrinkers (OR per AA genotype, 4.020; 95.0% CI: 1.211-13.339; P=0.017). In addition, we found that XPG rs17655 CG or GG genotype associated with decreased lung cancer risk in drinkers (OR per XPG rs17655 CG genotype, 0.238; 95.0% CI: 0.061~0.925; P=0.034; OR per XPG rs17655 GG genotype, 0.l39; 95.0% CI: 0.021-0.938; P=0.032). Haplotype analysis of all 7 SNPs ... |
format |
Article in Journal/Newspaper |
author |
Sha Xiao Wen-fang Long Yi-jiang Huang Shi-cheng Kuang Chong Meng Yun-ru Liu Yu-mei Liu Zhen Yan De-e Yu Fan Zhang |
author_facet |
Sha Xiao Wen-fang Long Yi-jiang Huang Shi-cheng Kuang Chong Meng Yun-ru Liu Yu-mei Liu Zhen Yan De-e Yu Fan Zhang |
author_sort |
Sha Xiao |
title |
Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study |
title_short |
Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study |
title_full |
Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study |
title_fullStr |
Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study |
title_full_unstemmed |
Polymorphisms in XPB and XPG subcomplexes of TFIIH is associated with lung cancer risk in a Chinese population: A case-control study |
title_sort |
polymorphisms in xpb and xpg subcomplexes of tfiih is associated with lung cancer risk in a chinese population: a case-control study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/1995-7645.243105 https://doaj.org/article/15e0553bcb364fcea283d4ec6b968639 |
long_lat |
ENVELOPE(6.622,6.622,62.612,62.612) |
geographic |
Arctic Ner |
geographic_facet |
Arctic Ner |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 11, Iss 13, Pp 37-37 (2018) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=13;spage=37;epage=37;aulast=Xiao https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.243105 https://doaj.org/article/15e0553bcb364fcea283d4ec6b968639 |
op_doi |
https://doi.org/10.4103/1995-7645.243105 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
11 |
container_issue |
13 |
container_start_page |
37 |
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1766347539606405120 |