Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study
Objective: To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with dengue. Methods: This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June 2022. Co...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:1577782df6084b4fb8430769b891f6d8 2023-11-12T04:13:17+01:00 Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study Govind R Patel Indu Thanvi Mohammad Nadeem Rahul Kanwaria 2023-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.370149 https://doaj.org/article/1577782df6084b4fb8430769b891f6d8 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=2;spage=65;epage=71;aulast=Patel https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.370149 https://doaj.org/article/1577782df6084b4fb8430769b891f6d8 Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 2, Pp 65-71 (2023) dengue coagulation abnormalities coagulation parameters prothrombin time activated partial thromboplastin time bleeding manifestations Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.4103/1995-7645.370149 2023-10-29T00:38:43Z Objective: To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with dengue. Methods: This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June 2022. Coagulation tests including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer were performed. Patients were monitored for bleeding manifestations. Results: Coagulation abnormalities were reported in 42.8% of the patients. Overall, prolonged aPTT was the most common coagulation abnormality (40.8%), followed by low fibrinogen (38.7%), raised D-dimer (31.2%), raised INR (26.0%) and prolonged PT (19.2%). Bleeding manifestations were present in 19.9% patients. PT, INR, aPTT and D-dimer levels were significantly higher (P<0.01) and fibrinogen level was significantly lower (P<0.001) in patients with bleeding compared to patients without bleeding. Patients with bleeding had a significantly higher rate of all coagulation abnormalities than patients without bleeding (P<0.01). Conclusions: Patients with bleeding showed a significantly higher frequency of coagulation abnormalities compared to patients without bleeding. Patients with dengue should be assessed for coagulation abnormalities. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Asian Pacific Journal of Tropical Medicine 16 2 65 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
dengue coagulation abnormalities coagulation parameters prothrombin time activated partial thromboplastin time bleeding manifestations Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
dengue coagulation abnormalities coagulation parameters prothrombin time activated partial thromboplastin time bleeding manifestations Arctic medicine. Tropical medicine RC955-962 Govind R Patel Indu Thanvi Mohammad Nadeem Rahul Kanwaria Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study |
topic_facet |
dengue coagulation abnormalities coagulation parameters prothrombin time activated partial thromboplastin time bleeding manifestations Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To evaluate coagulation abnormalities and their relationship with bleeding manifestations among patients with dengue. Methods: This observational study was conducted on 292 adult dengue patients who were admitted to a tertiary care hospital of Western India from July 2021 to June 2022. Coagulation tests including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer were performed. Patients were monitored for bleeding manifestations. Results: Coagulation abnormalities were reported in 42.8% of the patients. Overall, prolonged aPTT was the most common coagulation abnormality (40.8%), followed by low fibrinogen (38.7%), raised D-dimer (31.2%), raised INR (26.0%) and prolonged PT (19.2%). Bleeding manifestations were present in 19.9% patients. PT, INR, aPTT and D-dimer levels were significantly higher (P<0.01) and fibrinogen level was significantly lower (P<0.001) in patients with bleeding compared to patients without bleeding. Patients with bleeding had a significantly higher rate of all coagulation abnormalities than patients without bleeding (P<0.01). Conclusions: Patients with bleeding showed a significantly higher frequency of coagulation abnormalities compared to patients without bleeding. Patients with dengue should be assessed for coagulation abnormalities. |
format |
Article in Journal/Newspaper |
author |
Govind R Patel Indu Thanvi Mohammad Nadeem Rahul Kanwaria |
author_facet |
Govind R Patel Indu Thanvi Mohammad Nadeem Rahul Kanwaria |
author_sort |
Govind R Patel |
title |
Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study |
title_short |
Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study |
title_full |
Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study |
title_fullStr |
Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study |
title_full_unstemmed |
Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study |
title_sort |
coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-a single center observational study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2023 |
url |
https://doi.org/10.4103/1995-7645.370149 https://doaj.org/article/1577782df6084b4fb8430769b891f6d8 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 16, Iss 2, Pp 65-71 (2023) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=2;spage=65;epage=71;aulast=Patel https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.370149 https://doaj.org/article/1577782df6084b4fb8430769b891f6d8 |
op_doi |
https://doi.org/10.4103/1995-7645.370149 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
16 |
container_issue |
2 |
container_start_page |
65 |
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1782331352160403456 |