Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda.
Introduction Leptospira are a group of bacteria, including pathogenic types that cause leptospirosis. In Uganda, Leptospira exposure has been reported in humans, with domesticated animals being speculated as the source. However, comparable evidence of Leptospira prevalence and circulating serovars/s...
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ftdoajarticles:oai:doaj.org/article:152ce8289dff4e56afa5d45326178ae8 2024-09-09T19:28:12+00:00 Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. Lordrick Alinaitwe Christopher Joshua Aturinda Ashiraf Lubega Velma Kivali James Bugeza Martin Wainaina Martin H Richter Jolly Justine Hoona Kristina Roesel Anne Mayer-Scholl Elizabeth Anne Jessie Cook Clovice Kankya Salome Dürr 2024-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0012055 https://doaj.org/article/152ce8289dff4e56afa5d45326178ae8 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012055&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012055 https://doaj.org/article/152ce8289dff4e56afa5d45326178ae8 PLoS Neglected Tropical Diseases, Vol 18, Iss 3, p e0012055 (2024) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2024 ftdoajarticles https://doi.org/10.1371/journal.pntd.0012055 2024-08-05T17:49:27Z Introduction Leptospira are a group of bacteria, including pathogenic types that cause leptospirosis. In Uganda, Leptospira exposure has been reported in humans, with domesticated animals being speculated as the source. However, comparable evidence of Leptospira prevalence and circulating serovars/serogroups in animals is only documented for cattle, and dogs. Our study determined Leptospira seroprevalence, associated risk factors and serogroups circulating among slaughtered pigs, goats, and sheep in Uganda. Methods During an 11-month cross-sectional survey in selected slaughter facilities in three regions of Uganda, we collected blood from 926 pigs, 347 goats, and 116 sheep. The age, sex, breed, and origin of each sampled animal were noted. The samples were tested for anti-Leptospira antibodies using the microscopic agglutination test, based on a panel of 12 serovars belonging to 12 serogroups. Results Leptospira seroprevalence was 26.67% (247/926, 95%CI 23.92-29.61) among pigs, and 21.81% (101/463, 95%CI 18.29-25.80) in goats and sheep (small ruminants). L. interrogans Australis and L. kirschneri Grippotyphosa were the commonest serovars among pigs, as was L. borgpetersenii Tarassovi in small ruminants. Pigs sourced from the Eastern (Odds Ratio [OR] = 2.82, 95%CI 1.84-4.30) and Northern (OR = 3.56, 95%CI 2.52-5.02) regions were more likely to be seropositive, compared to those from the Central region. For small ruminants, being female (OR 2.74, 95% CI 1.69-4.57) and adult (OR 4.47, 95% CI 1.57-18.80) was significantly more associated with Leptospira seropositivity. Conclusion/significance: Detection of a moderate seroprevalence, and several Leptospira serogroups among pigs, sheep, and goats from all regions of Uganda, supports existing reports in cattle and dogs, and implies widespread Leptospira exposure in domestic animals in Uganda. These findings may inform future programs for the control of leptospirosis in livestock in Uganda. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Slaughter ENVELOPE(-85.633,-85.633,-78.617,-78.617) PLOS Neglected Tropical Diseases 18 3 e0012055 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lordrick Alinaitwe Christopher Joshua Aturinda Ashiraf Lubega Velma Kivali James Bugeza Martin Wainaina Martin H Richter Jolly Justine Hoona Kristina Roesel Anne Mayer-Scholl Elizabeth Anne Jessie Cook Clovice Kankya Salome Dürr Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Introduction Leptospira are a group of bacteria, including pathogenic types that cause leptospirosis. In Uganda, Leptospira exposure has been reported in humans, with domesticated animals being speculated as the source. However, comparable evidence of Leptospira prevalence and circulating serovars/serogroups in animals is only documented for cattle, and dogs. Our study determined Leptospira seroprevalence, associated risk factors and serogroups circulating among slaughtered pigs, goats, and sheep in Uganda. Methods During an 11-month cross-sectional survey in selected slaughter facilities in three regions of Uganda, we collected blood from 926 pigs, 347 goats, and 116 sheep. The age, sex, breed, and origin of each sampled animal were noted. The samples were tested for anti-Leptospira antibodies using the microscopic agglutination test, based on a panel of 12 serovars belonging to 12 serogroups. Results Leptospira seroprevalence was 26.67% (247/926, 95%CI 23.92-29.61) among pigs, and 21.81% (101/463, 95%CI 18.29-25.80) in goats and sheep (small ruminants). L. interrogans Australis and L. kirschneri Grippotyphosa were the commonest serovars among pigs, as was L. borgpetersenii Tarassovi in small ruminants. Pigs sourced from the Eastern (Odds Ratio [OR] = 2.82, 95%CI 1.84-4.30) and Northern (OR = 3.56, 95%CI 2.52-5.02) regions were more likely to be seropositive, compared to those from the Central region. For small ruminants, being female (OR 2.74, 95% CI 1.69-4.57) and adult (OR 4.47, 95% CI 1.57-18.80) was significantly more associated with Leptospira seropositivity. Conclusion/significance: Detection of a moderate seroprevalence, and several Leptospira serogroups among pigs, sheep, and goats from all regions of Uganda, supports existing reports in cattle and dogs, and implies widespread Leptospira exposure in domestic animals in Uganda. These findings may inform future programs for the control of leptospirosis in livestock in Uganda. |
format |
Article in Journal/Newspaper |
author |
Lordrick Alinaitwe Christopher Joshua Aturinda Ashiraf Lubega Velma Kivali James Bugeza Martin Wainaina Martin H Richter Jolly Justine Hoona Kristina Roesel Anne Mayer-Scholl Elizabeth Anne Jessie Cook Clovice Kankya Salome Dürr |
author_facet |
Lordrick Alinaitwe Christopher Joshua Aturinda Ashiraf Lubega Velma Kivali James Bugeza Martin Wainaina Martin H Richter Jolly Justine Hoona Kristina Roesel Anne Mayer-Scholl Elizabeth Anne Jessie Cook Clovice Kankya Salome Dürr |
author_sort |
Lordrick Alinaitwe |
title |
Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. |
title_short |
Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. |
title_full |
Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. |
title_fullStr |
Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. |
title_full_unstemmed |
Cross-sectional serosurvey of Leptospira species among slaughter pigs, goats, and sheep in Uganda. |
title_sort |
cross-sectional serosurvey of leptospira species among slaughter pigs, goats, and sheep in uganda. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2024 |
url |
https://doi.org/10.1371/journal.pntd.0012055 https://doaj.org/article/152ce8289dff4e56afa5d45326178ae8 |
long_lat |
ENVELOPE(-85.633,-85.633,-78.617,-78.617) |
geographic |
Arctic Slaughter |
geographic_facet |
Arctic Slaughter |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 18, Iss 3, p e0012055 (2024) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012055&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0012055 https://doaj.org/article/152ce8289dff4e56afa5d45326178ae8 |
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https://doi.org/10.1371/journal.pntd.0012055 |
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PLOS Neglected Tropical Diseases |
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