Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats

Objective: To study the effect of water extract of Solanum torvum (S. torvum) on blood lipid and sex hormone levels in high-fat diet (HFD) fed male rats. Methods: Male Wistar rats were maintained on a standard diet or HFD for 10 weeks. During the last 4 weeks, the standard diet groups received disti...

Full description

Bibliographic Details
Published in:Asian Pacific Journal of Tropical Biomedicine
Main Authors: Supaporn Wannasiri, Sunee Chansakaow, Seewaboon Sireeratawong
Format: Article in Journal/Newspaper
Language:English
Published: Wolters Kluwer Medknow Publications 2017
Subjects:
Online Access:https://doi.org/10.1016/j.apjtb.2017.01.027
https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af
id ftdoajarticles:oai:doaj.org/article:14bfdd4ca1124becbbe470186960e6af
record_format openpolar
spelling ftdoajarticles:oai:doaj.org/article:14bfdd4ca1124becbbe470186960e6af 2023-05-15T15:11:52+02:00 Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats Supaporn Wannasiri Sunee Chansakaow Seewaboon Sireeratawong 2017-05-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116303483 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 5, Pp 401-405 (2017) Solanum torvum Obesity Hyperlipidemia Testosterone Estradiol Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2017.01.027 2022-12-30T23:05:57Z Objective: To study the effect of water extract of Solanum torvum (S. torvum) on blood lipid and sex hormone levels in high-fat diet (HFD) fed male rats. Methods: Male Wistar rats were maintained on a standard diet or HFD for 10 weeks. During the last 4 weeks, the standard diet groups received distilled water or S. torvum (400 mg/kg) and the HFD groups received distilled water or S. torvum (100, 200 and 400 mg/kg). Body weight, lipid profiles, sex hormone, internal organs weight and liver histopathology were all measured. Moreover, kidney function was evaluated using blood urea nitrogen and creatinine levels, and liver function by the levels of aspartate aminotransferase and alanine aminotransferase. Results: The result showed that rats in the HFD control group had increased body weight and hyperlipidemia, but had decreased levels of both testosterone and estradiol. When receiving the S. torvum extract at a dose of 100 mg/kg, treated rats had significantly increased sex hormone levels of both types, and decreased total cholesterol levels, and at a dose of 200 mg/kg, treated rats had significantly decreased levels of triglyceride. Long term administration of the S. torvum did not produce any toxic signs in livers and kidneys. Pathological examinations of livers showed lipid accumulation in the HFD group, but the treatment of S. torvum slightly reduced lipid deposition in liver tissue. Conclusions: S. torvum extract can reverse the level of sex hormones to their normal level and reduce serum cholesterol in HFD-induced obese male rats. Furthermore, the long term oral administration of S. torvum extract is harmless. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 5 401 405
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Solanum torvum
Obesity
Hyperlipidemia
Testosterone
Estradiol
Arctic medicine. Tropical medicine
RC955-962
Biology (General)
QH301-705.5
spellingShingle Solanum torvum
Obesity
Hyperlipidemia
Testosterone
Estradiol
Arctic medicine. Tropical medicine
RC955-962
Biology (General)
QH301-705.5
Supaporn Wannasiri
Sunee Chansakaow
Seewaboon Sireeratawong
Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
topic_facet Solanum torvum
Obesity
Hyperlipidemia
Testosterone
Estradiol
Arctic medicine. Tropical medicine
RC955-962
Biology (General)
QH301-705.5
description Objective: To study the effect of water extract of Solanum torvum (S. torvum) on blood lipid and sex hormone levels in high-fat diet (HFD) fed male rats. Methods: Male Wistar rats were maintained on a standard diet or HFD for 10 weeks. During the last 4 weeks, the standard diet groups received distilled water or S. torvum (400 mg/kg) and the HFD groups received distilled water or S. torvum (100, 200 and 400 mg/kg). Body weight, lipid profiles, sex hormone, internal organs weight and liver histopathology were all measured. Moreover, kidney function was evaluated using blood urea nitrogen and creatinine levels, and liver function by the levels of aspartate aminotransferase and alanine aminotransferase. Results: The result showed that rats in the HFD control group had increased body weight and hyperlipidemia, but had decreased levels of both testosterone and estradiol. When receiving the S. torvum extract at a dose of 100 mg/kg, treated rats had significantly increased sex hormone levels of both types, and decreased total cholesterol levels, and at a dose of 200 mg/kg, treated rats had significantly decreased levels of triglyceride. Long term administration of the S. torvum did not produce any toxic signs in livers and kidneys. Pathological examinations of livers showed lipid accumulation in the HFD group, but the treatment of S. torvum slightly reduced lipid deposition in liver tissue. Conclusions: S. torvum extract can reverse the level of sex hormones to their normal level and reduce serum cholesterol in HFD-induced obese male rats. Furthermore, the long term oral administration of S. torvum extract is harmless.
format Article in Journal/Newspaper
author Supaporn Wannasiri
Sunee Chansakaow
Seewaboon Sireeratawong
author_facet Supaporn Wannasiri
Sunee Chansakaow
Seewaboon Sireeratawong
author_sort Supaporn Wannasiri
title Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
title_short Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
title_full Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
title_fullStr Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
title_full_unstemmed Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
title_sort effects of solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
publisher Wolters Kluwer Medknow Publications
publishDate 2017
url https://doi.org/10.1016/j.apjtb.2017.01.027
https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 5, Pp 401-405 (2017)
op_relation http://www.sciencedirect.com/science/article/pii/S2221169116303483
https://doaj.org/toc/2221-1691
2221-1691
doi:10.1016/j.apjtb.2017.01.027
https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af
op_doi https://doi.org/10.1016/j.apjtb.2017.01.027
container_title Asian Pacific Journal of Tropical Biomedicine
container_volume 7
container_issue 5
container_start_page 401
op_container_end_page 405
_version_ 1766342646445375488