Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats
Objective: To study the effect of water extract of Solanum torvum (S. torvum) on blood lipid and sex hormone levels in high-fat diet (HFD) fed male rats. Methods: Male Wistar rats were maintained on a standard diet or HFD for 10 weeks. During the last 4 weeks, the standard diet groups received disti...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af |
id |
ftdoajarticles:oai:doaj.org/article:14bfdd4ca1124becbbe470186960e6af |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:14bfdd4ca1124becbbe470186960e6af 2023-05-15T15:11:52+02:00 Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats Supaporn Wannasiri Sunee Chansakaow Seewaboon Sireeratawong 2017-05-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116303483 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 5, Pp 401-405 (2017) Solanum torvum Obesity Hyperlipidemia Testosterone Estradiol Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2017.01.027 2022-12-30T23:05:57Z Objective: To study the effect of water extract of Solanum torvum (S. torvum) on blood lipid and sex hormone levels in high-fat diet (HFD) fed male rats. Methods: Male Wistar rats were maintained on a standard diet or HFD for 10 weeks. During the last 4 weeks, the standard diet groups received distilled water or S. torvum (400 mg/kg) and the HFD groups received distilled water or S. torvum (100, 200 and 400 mg/kg). Body weight, lipid profiles, sex hormone, internal organs weight and liver histopathology were all measured. Moreover, kidney function was evaluated using blood urea nitrogen and creatinine levels, and liver function by the levels of aspartate aminotransferase and alanine aminotransferase. Results: The result showed that rats in the HFD control group had increased body weight and hyperlipidemia, but had decreased levels of both testosterone and estradiol. When receiving the S. torvum extract at a dose of 100 mg/kg, treated rats had significantly increased sex hormone levels of both types, and decreased total cholesterol levels, and at a dose of 200 mg/kg, treated rats had significantly decreased levels of triglyceride. Long term administration of the S. torvum did not produce any toxic signs in livers and kidneys. Pathological examinations of livers showed lipid accumulation in the HFD group, but the treatment of S. torvum slightly reduced lipid deposition in liver tissue. Conclusions: S. torvum extract can reverse the level of sex hormones to their normal level and reduce serum cholesterol in HFD-induced obese male rats. Furthermore, the long term oral administration of S. torvum extract is harmless. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 5 401 405 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Solanum torvum Obesity Hyperlipidemia Testosterone Estradiol Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Solanum torvum Obesity Hyperlipidemia Testosterone Estradiol Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Supaporn Wannasiri Sunee Chansakaow Seewaboon Sireeratawong Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
topic_facet |
Solanum torvum Obesity Hyperlipidemia Testosterone Estradiol Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To study the effect of water extract of Solanum torvum (S. torvum) on blood lipid and sex hormone levels in high-fat diet (HFD) fed male rats. Methods: Male Wistar rats were maintained on a standard diet or HFD for 10 weeks. During the last 4 weeks, the standard diet groups received distilled water or S. torvum (400 mg/kg) and the HFD groups received distilled water or S. torvum (100, 200 and 400 mg/kg). Body weight, lipid profiles, sex hormone, internal organs weight and liver histopathology were all measured. Moreover, kidney function was evaluated using blood urea nitrogen and creatinine levels, and liver function by the levels of aspartate aminotransferase and alanine aminotransferase. Results: The result showed that rats in the HFD control group had increased body weight and hyperlipidemia, but had decreased levels of both testosterone and estradiol. When receiving the S. torvum extract at a dose of 100 mg/kg, treated rats had significantly increased sex hormone levels of both types, and decreased total cholesterol levels, and at a dose of 200 mg/kg, treated rats had significantly decreased levels of triglyceride. Long term administration of the S. torvum did not produce any toxic signs in livers and kidneys. Pathological examinations of livers showed lipid accumulation in the HFD group, but the treatment of S. torvum slightly reduced lipid deposition in liver tissue. Conclusions: S. torvum extract can reverse the level of sex hormones to their normal level and reduce serum cholesterol in HFD-induced obese male rats. Furthermore, the long term oral administration of S. torvum extract is harmless. |
format |
Article in Journal/Newspaper |
author |
Supaporn Wannasiri Sunee Chansakaow Seewaboon Sireeratawong |
author_facet |
Supaporn Wannasiri Sunee Chansakaow Seewaboon Sireeratawong |
author_sort |
Supaporn Wannasiri |
title |
Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
title_short |
Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
title_full |
Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
title_fullStr |
Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
title_full_unstemmed |
Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
title_sort |
effects of solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 5, Pp 401-405 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116303483 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2017.01.027 https://doaj.org/article/14bfdd4ca1124becbbe470186960e6af |
op_doi |
https://doi.org/10.1016/j.apjtb.2017.01.027 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
5 |
container_start_page |
401 |
op_container_end_page |
405 |
_version_ |
1766342646445375488 |