Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening.
The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with an...
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ftdoajarticles:oai:doaj.org/article:14b3aed3fdf04bb6a952cfd6759f3373 2023-05-15T15:02:51+02:00 Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. María Pilar Arenaz-Callao Rubén González Del Río Ainhoa Lucía Quintana Charles J Thompson Alfonso Mendoza-Losana Santiago Ramón-García 2019-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007126 https://doaj.org/article/14b3aed3fdf04bb6a952cfd6759f3373 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6366712?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007126 https://doaj.org/article/14b3aed3fdf04bb6a952cfd6759f3373 PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007126 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007126 2022-12-31T12:03:21Z The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently used to treat BU, i.e. rifampicin and clarithromycin; this activity was further potentiated in the presence of the beta-lactamase inhibitor clavulanate. In addition, quadruple combinations of rifampicin, clarithromycin, clavulanate and beta-lactams resulted in multiplicative reductions in their minimal inhibitory concentration (MIC) values. The MIC of amoxicillin against a panel of clinical isolates decreased more than 200-fold within this quadruple combination. Amoxicillin/clavulanate formulations are readily available with clinical pedigree, low toxicity, and orally and pediatric available; thus, supporting its potential inclusion as a new anti-BU drug in current combination therapies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 1 e0007126 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 María Pilar Arenaz-Callao Rubén González Del Río Ainhoa Lucía Quintana Charles J Thompson Alfonso Mendoza-Losana Santiago Ramón-García Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The potential use of clinically approved beta-lactams for Buruli ulcer (BU) treatment was investigated with representative classes analyzed in vitro for activity against Mycobacterium ulcerans. Beta-lactams tested were effective alone and displayed a strong synergistic profile in combination with antibiotics currently used to treat BU, i.e. rifampicin and clarithromycin; this activity was further potentiated in the presence of the beta-lactamase inhibitor clavulanate. In addition, quadruple combinations of rifampicin, clarithromycin, clavulanate and beta-lactams resulted in multiplicative reductions in their minimal inhibitory concentration (MIC) values. The MIC of amoxicillin against a panel of clinical isolates decreased more than 200-fold within this quadruple combination. Amoxicillin/clavulanate formulations are readily available with clinical pedigree, low toxicity, and orally and pediatric available; thus, supporting its potential inclusion as a new anti-BU drug in current combination therapies. |
format |
Article in Journal/Newspaper |
author |
María Pilar Arenaz-Callao Rubén González Del Río Ainhoa Lucía Quintana Charles J Thompson Alfonso Mendoza-Losana Santiago Ramón-García |
author_facet |
María Pilar Arenaz-Callao Rubén González Del Río Ainhoa Lucía Quintana Charles J Thompson Alfonso Mendoza-Losana Santiago Ramón-García |
author_sort |
María Pilar Arenaz-Callao |
title |
Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. |
title_short |
Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. |
title_full |
Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. |
title_fullStr |
Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. |
title_full_unstemmed |
Triple oral beta-lactam containing therapy for Buruli ulcer treatment shortening. |
title_sort |
triple oral beta-lactam containing therapy for buruli ulcer treatment shortening. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007126 https://doaj.org/article/14b3aed3fdf04bb6a952cfd6759f3373 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007126 (2019) |
op_relation |
http://europepmc.org/articles/PMC6366712?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007126 https://doaj.org/article/14b3aed3fdf04bb6a952cfd6759f3373 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007126 |
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PLOS Neglected Tropical Diseases |
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13 |
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1 |
container_start_page |
e0007126 |
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1766334766072725504 |