Prioritizing surveillance of Nipah virus in India.
The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genus Henipavirus, causes severe disease and stuttering chains of transmiss...
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ftdoajarticles:oai:doaj.org/article:14a7d074a3df4f04b31d8eb44773b881 2023-05-15T15:14:29+02:00 Prioritizing surveillance of Nipah virus in India. Raina K Plowright Daniel J Becker Daniel E Crowley Alex D Washburne Tao Huang P O Nameer Emily S Gurley Barbara A Han 2019-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007393 https://doaj.org/article/14a7d074a3df4f04b31d8eb44773b881 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007393 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007393 https://doaj.org/article/14a7d074a3df4f04b31d8eb44773b881 PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007393 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007393 2023-02-19T01:47:55Z The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genus Henipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala, > 1800 km from the sites of previous outbreaks in eastern India in 2001 and 2007. Twenty-three people were infected and 21 people died (16 deaths and 18 cases were laboratory confirmed). Initial surveillance focused on insectivorous bats (Megaderma spasma), whereas follow-up surveys within Kerala found evidence of Nipah virus in fruit bats (Pteropus medius). P. medius is the confirmed host in Bangladesh and is now a confirmed host in India. However, other bat species may also serve as reservoir hosts of henipaviruses. To inform surveillance of Nipah virus in bats, we reviewed and analyzed the published records of Nipah virus surveillance globally. We applied a trait-based machine learning approach to a subset of species that occur in Asia, Australia, and Oceana. In addition to seven species in Kerala that were previously identified as Nipah virus seropositive, we identified at least four bat species that, on the basis of trait similarity with known Nipah virus-seropositive species, have a relatively high likelihood of exposure to Nipah or Nipah-like viruses in India. These machine-learning approaches provide the first step in the sequence of studies required to assess the risk of Nipah virus spillover in India. Nipah virus surveillance not only within Kerala but also elsewhere in India would benefit from a research pipeline that included surveys of known and predicted reservoirs for serological evidence of past infection with Nipah virus (or cross reacting henipaviruses). Serosurveys should then be followed by longitudinal spatial and temporal studies to detect shedding and isolate virus from ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Oceana ENVELOPE(-59.783,-59.783,-65.133,-65.133) PLOS Neglected Tropical Diseases 13 6 e0007393 |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Raina K Plowright Daniel J Becker Daniel E Crowley Alex D Washburne Tao Huang P O Nameer Emily S Gurley Barbara A Han Prioritizing surveillance of Nipah virus in India. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genus Henipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala, > 1800 km from the sites of previous outbreaks in eastern India in 2001 and 2007. Twenty-three people were infected and 21 people died (16 deaths and 18 cases were laboratory confirmed). Initial surveillance focused on insectivorous bats (Megaderma spasma), whereas follow-up surveys within Kerala found evidence of Nipah virus in fruit bats (Pteropus medius). P. medius is the confirmed host in Bangladesh and is now a confirmed host in India. However, other bat species may also serve as reservoir hosts of henipaviruses. To inform surveillance of Nipah virus in bats, we reviewed and analyzed the published records of Nipah virus surveillance globally. We applied a trait-based machine learning approach to a subset of species that occur in Asia, Australia, and Oceana. In addition to seven species in Kerala that were previously identified as Nipah virus seropositive, we identified at least four bat species that, on the basis of trait similarity with known Nipah virus-seropositive species, have a relatively high likelihood of exposure to Nipah or Nipah-like viruses in India. These machine-learning approaches provide the first step in the sequence of studies required to assess the risk of Nipah virus spillover in India. Nipah virus surveillance not only within Kerala but also elsewhere in India would benefit from a research pipeline that included surveys of known and predicted reservoirs for serological evidence of past infection with Nipah virus (or cross reacting henipaviruses). Serosurveys should then be followed by longitudinal spatial and temporal studies to detect shedding and isolate virus from ... |
format |
Article in Journal/Newspaper |
author |
Raina K Plowright Daniel J Becker Daniel E Crowley Alex D Washburne Tao Huang P O Nameer Emily S Gurley Barbara A Han |
author_facet |
Raina K Plowright Daniel J Becker Daniel E Crowley Alex D Washburne Tao Huang P O Nameer Emily S Gurley Barbara A Han |
author_sort |
Raina K Plowright |
title |
Prioritizing surveillance of Nipah virus in India. |
title_short |
Prioritizing surveillance of Nipah virus in India. |
title_full |
Prioritizing surveillance of Nipah virus in India. |
title_fullStr |
Prioritizing surveillance of Nipah virus in India. |
title_full_unstemmed |
Prioritizing surveillance of Nipah virus in India. |
title_sort |
prioritizing surveillance of nipah virus in india. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007393 https://doaj.org/article/14a7d074a3df4f04b31d8eb44773b881 |
long_lat |
ENVELOPE(-59.783,-59.783,-65.133,-65.133) |
geographic |
Arctic Oceana |
geographic_facet |
Arctic Oceana |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 6, p e0007393 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007393 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007393 https://doaj.org/article/14a7d074a3df4f04b31d8eb44773b881 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007393 |
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PLOS Neglected Tropical Diseases |
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13 |
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6 |
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e0007393 |
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