Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil
Abstract Background Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over successive pregnancies. Most studies that investigated malaria antibody responses in pregnant women are from high transmission areas in sub-Saharan Africa, while r...
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ftdoajarticles:oai:doaj.org/article:145769ab7c974e88849fdad194847212 2023-05-15T15:17:32+02:00 Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil Meseret W. Kassa Wina Hasang André Barateiro Timon Damelang Jessica Brewster Jamille G. Dombrowski Rhea J. Longley Amy W. Chung Gerhard Wunderlich Ivo Mueller Elizabeth H. Aitken Claudio R. F. Marinho Stephen J. Rogerson 2022-12-01T00:00:00Z https://doi.org/10.1186/s12936-022-04402-4 https://doaj.org/article/145769ab7c974e88849fdad194847212 EN eng BMC https://doi.org/10.1186/s12936-022-04402-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04402-4 1475-2875 https://doaj.org/article/145769ab7c974e88849fdad194847212 Malaria Journal, Vol 21, Iss 1, Pp 1-14 (2022) Pregnancy malaria Antibody P. falciparum P. vivax Low transmission Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2022 ftdoajarticles https://doi.org/10.1186/s12936-022-04402-4 2022-12-30T20:13:58Z Abstract Background Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over successive pregnancies. Most studies that investigated malaria antibody responses in pregnant women are from high transmission areas in sub-Saharan Africa, while reports from Latin America are scarce and inconsistent. The present study sought to explore the development of antibodies against P. falciparum and Plasmodium vivax antigens in pregnant women living in a low transmission area in the Brazilian Amazon. Methods In a prospective cohort study, plasma samples from 408 pregnant women (of whom 111 were infected with P. falciparum, 96 had infections with P. falciparum and P. vivax, and 201 had no Plasmodium infection) were used to measure antibody levels. Levels of IgG and opsonizing antibody to pregnancy-specific variant surface antigens (VSAs) on infected erythrocytes (IEs), 10 recombinant VAR2CSA Duffy binding like (DBL domains), 10 non-pregnancy-specific P. falciparum merozoite antigens, and 10 P. vivax antigens were measured by flow cytometry, ELISA, and multiplex assays. Antibody levels and seropositivity among the groups were compared. Results Antibodies to VSAs on P. falciparum IEs were generally low but were higher in currently infected women and women with multiple P. falciparum episodes over pregnancy. Many women (21%-69%) had antibodies against each individual VAR2CSA DBL domain, and antibodies to DBLs correlated with each other (r ≥ 0.55, p < 0.0001), but not with antibody to VSA or history of infection. Infection with either malaria species was associated with higher seropositivity rate for antibodies against P. vivax proteins, adjusted odds ratios (95% CI) ranged from 5.6 (3.2, 9.7), p < 0.0001 for PVDBPII-Sal1 to 15.7 (8.3, 29.7), p < 0.0001 for PvTRAg_2. Conclusions Pregnant Brazilian women had low levels of antibodies to pregnancy-specific VSAs that increased with exposure. They frequently recognized both VAR2CSA DBL domains and P. vivax antigens, but ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 21 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Pregnancy malaria Antibody P. falciparum P. vivax Low transmission Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Pregnancy malaria Antibody P. falciparum P. vivax Low transmission Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Meseret W. Kassa Wina Hasang André Barateiro Timon Damelang Jessica Brewster Jamille G. Dombrowski Rhea J. Longley Amy W. Chung Gerhard Wunderlich Ivo Mueller Elizabeth H. Aitken Claudio R. F. Marinho Stephen J. Rogerson Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil |
topic_facet |
Pregnancy malaria Antibody P. falciparum P. vivax Low transmission Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Pregnant women have increased susceptibility to Plasmodium falciparum malaria and acquire protective antibodies over successive pregnancies. Most studies that investigated malaria antibody responses in pregnant women are from high transmission areas in sub-Saharan Africa, while reports from Latin America are scarce and inconsistent. The present study sought to explore the development of antibodies against P. falciparum and Plasmodium vivax antigens in pregnant women living in a low transmission area in the Brazilian Amazon. Methods In a prospective cohort study, plasma samples from 408 pregnant women (of whom 111 were infected with P. falciparum, 96 had infections with P. falciparum and P. vivax, and 201 had no Plasmodium infection) were used to measure antibody levels. Levels of IgG and opsonizing antibody to pregnancy-specific variant surface antigens (VSAs) on infected erythrocytes (IEs), 10 recombinant VAR2CSA Duffy binding like (DBL domains), 10 non-pregnancy-specific P. falciparum merozoite antigens, and 10 P. vivax antigens were measured by flow cytometry, ELISA, and multiplex assays. Antibody levels and seropositivity among the groups were compared. Results Antibodies to VSAs on P. falciparum IEs were generally low but were higher in currently infected women and women with multiple P. falciparum episodes over pregnancy. Many women (21%-69%) had antibodies against each individual VAR2CSA DBL domain, and antibodies to DBLs correlated with each other (r ≥ 0.55, p < 0.0001), but not with antibody to VSA or history of infection. Infection with either malaria species was associated with higher seropositivity rate for antibodies against P. vivax proteins, adjusted odds ratios (95% CI) ranged from 5.6 (3.2, 9.7), p < 0.0001 for PVDBPII-Sal1 to 15.7 (8.3, 29.7), p < 0.0001 for PvTRAg_2. Conclusions Pregnant Brazilian women had low levels of antibodies to pregnancy-specific VSAs that increased with exposure. They frequently recognized both VAR2CSA DBL domains and P. vivax antigens, but ... |
format |
Article in Journal/Newspaper |
author |
Meseret W. Kassa Wina Hasang André Barateiro Timon Damelang Jessica Brewster Jamille G. Dombrowski Rhea J. Longley Amy W. Chung Gerhard Wunderlich Ivo Mueller Elizabeth H. Aitken Claudio R. F. Marinho Stephen J. Rogerson |
author_facet |
Meseret W. Kassa Wina Hasang André Barateiro Timon Damelang Jessica Brewster Jamille G. Dombrowski Rhea J. Longley Amy W. Chung Gerhard Wunderlich Ivo Mueller Elizabeth H. Aitken Claudio R. F. Marinho Stephen J. Rogerson |
author_sort |
Meseret W. Kassa |
title |
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil |
title_short |
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil |
title_full |
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil |
title_fullStr |
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil |
title_full_unstemmed |
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil |
title_sort |
acquisition of antibodies to plasmodium falciparum and plasmodium vivax antigens in pregnant women living in a low malaria transmission area of brazil |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s12936-022-04402-4 https://doaj.org/article/145769ab7c974e88849fdad194847212 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 21, Iss 1, Pp 1-14 (2022) |
op_relation |
https://doi.org/10.1186/s12936-022-04402-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04402-4 1475-2875 https://doaj.org/article/145769ab7c974e88849fdad194847212 |
op_doi |
https://doi.org/10.1186/s12936-022-04402-4 |
container_title |
Malaria Journal |
container_volume |
21 |
container_issue |
1 |
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1766347775999475712 |