Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic
Abstract Background Since several malaria parasite species are usually present in a particular area, co-infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed infections, parasite densities of the cryptic species may be low and o...
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ftdoajarticles:oai:doaj.org/article:144b834047544ae8a9aff1c9dada0c40 2023-05-15T15:17:37+02:00 Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic Cynthia Bichara Philippe Flahaut Damien Costa Anne-Lise Bienvenu Stephane Picot Gilles Gargala 2017-08-01T00:00:00Z https://doi.org/10.1186/s12936-017-1979-5 https://doaj.org/article/144b834047544ae8a9aff1c9dada0c40 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-1979-5 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1979-5 1475-2875 https://doaj.org/article/144b834047544ae8a9aff1c9dada0c40 Malaria Journal, Vol 16, Iss 1, Pp 1-4 (2017) Malaria Plasmodium Cryptic Diagnosis Follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-1979-5 2022-12-31T14:07:43Z Abstract Background Since several malaria parasite species are usually present in a particular area, co-infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Case presentation Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium malariae co-infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Conclusions Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium Cryptic Diagnosis Follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Plasmodium Cryptic Diagnosis Follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Cynthia Bichara Philippe Flahaut Damien Costa Anne-Lise Bienvenu Stephane Picot Gilles Gargala Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic |
topic_facet |
Malaria Plasmodium Cryptic Diagnosis Follow-up Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Since several malaria parasite species are usually present in a particular area, co-infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed infections, parasite densities of the cryptic species may be low and often not recognized in clinical practice. Case presentation Two children (3 and 6 years old) adopted recently from Central African Republic were admitted to hospital because of intermittent fever. Thin blood smears stained with Giemsa showed Plasmodium falciparum and Plasmodium malariae co-infection for both children at admission. They were both treated with atovaquone-proguanil combination for 3 days. At day 7, both thin blood smears examination remained negative but at day 28, thin blood smear was positive for P. malariae trophozoites and for Plasmodium ovale for the girl and her brother, respectively. Samples collected at day 1 and day 28 were submitted to real-time PCR showing the presence of the three parasite species (P. falciparum, P malariae and P. ovale) in admission blood samples from the two children and only P. ovale at day 28. Conclusions Twenty-eight days follow-up after treatment led to detection of a third parasite species in the blood of these two patients suggesting covert co-infection and a delayed appearance of one cryptic species following treatment. Concurrently infecting malaria species could be mutually suppressive, with P. falciparum tending to dominate other species. These observations provide more evidence that recommendations for treatment of imported malaria should take into account the risk of concurrent or cryptic infection with Plasmodium species. Clinicians and biologists should be aware of the underestimated frequency of mixed infections with cryptic species and of the importance of patient follow-up at day 28. Future guidelines should shed more light on the treatment of mixed infection and on the interest of using artemisinin-based combinations for falciparum and non-falciparum ... |
format |
Article in Journal/Newspaper |
author |
Cynthia Bichara Philippe Flahaut Damien Costa Anne-Lise Bienvenu Stephane Picot Gilles Gargala |
author_facet |
Cynthia Bichara Philippe Flahaut Damien Costa Anne-Lise Bienvenu Stephane Picot Gilles Gargala |
author_sort |
Cynthia Bichara |
title |
Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic |
title_short |
Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic |
title_full |
Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic |
title_fullStr |
Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic |
title_full_unstemmed |
Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic |
title_sort |
cryptic plasmodium ovale concurrent with mixed plasmodium falciparum and plasmodium malariae infection in two children from central african republic |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-1979-5 https://doaj.org/article/144b834047544ae8a9aff1c9dada0c40 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-4 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-1979-5 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1979-5 1475-2875 https://doaj.org/article/144b834047544ae8a9aff1c9dada0c40 |
op_doi |
https://doi.org/10.1186/s12936-017-1979-5 |
container_title |
Malaria Journal |
container_volume |
16 |
container_issue |
1 |
_version_ |
1766347860060667904 |