Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice
Drugs for inflammatory bowel diseases can be associated with serious side effects, and the development of alternative candidate resources derived from natural products has attracted considerable attention. Oyster extract (OE) derived from Crassostrea gigas contains glycogen, taurine, and amino acids...
Published in: | Foods |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2022
|
Subjects: | |
Online Access: | https://doi.org/10.3390/foods11030373 https://doaj.org/article/14336674d99a4a5ba616f83c54231f6d |
id |
ftdoajarticles:oai:doaj.org/article:14336674d99a4a5ba616f83c54231f6d |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:14336674d99a4a5ba616f83c54231f6d 2023-05-15T15:57:44+02:00 Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Ryota Hosomi Takaki Shimono Seiji Kanda Toshimasa Nishiyama Kenji Fukunaga Munehiro Yoshida 2022-01-01T00:00:00Z https://doi.org/10.3390/foods11030373 https://doaj.org/article/14336674d99a4a5ba616f83c54231f6d EN eng MDPI AG https://www.mdpi.com/2304-8158/11/3/373 https://doaj.org/toc/2304-8158 doi:10.3390/foods11030373 2304-8158 https://doaj.org/article/14336674d99a4a5ba616f83c54231f6d Foods, Vol 11, Iss 373, p 373 (2022) oyster extract Crassostrea gigas inflammatory bowel disease experimental colitis microbiota short-chain fatty acid Chemical technology TP1-1185 article 2022 ftdoajarticles https://doi.org/10.3390/foods11030373 2022-12-31T15:46:30Z Drugs for inflammatory bowel diseases can be associated with serious side effects, and the development of alternative candidate resources derived from natural products has attracted considerable attention. Oyster extract (OE) derived from Crassostrea gigas contains glycogen, taurine, and amino acids, and has been assigned diverse health-promoting properties. This study investigated the anti-colitis effect of OE intake on fecal microbiota and its metabolites of acute experimental colitis mouse model induced by dextran sulfate sodium (DSS). C57BL/6J mice (male) were divided into three groups: (1) American Institute of Nutrition (AIN) 93G diet + DSS-untreated, (2) AIN93G diet + DSS-treated, and (3) 5% OE diet + DSS-treated. Mice were fed each diet for 21 days, and then administered 2.5% DSS solution to induce acute colitis for 7 days. In DSS-induced colitis mice, OE decreased body weight loss and increased disease activity index during the DSS-induced period. In addition, OE tended to decrease the colon length shortening and the relative spleen weight and alleviated colonic tissue damage. Moreover, OE improved fecal short-chain fatty acids compositions and altered the structure of fecal microbiota. These results provide insight into the health-promoting property of OE in alleviating DSS-induced acute colitis, providing a basis for the development and use of functional foods. Article in Journal/Newspaper Crassostrea gigas Directory of Open Access Journals: DOAJ Articles Foods 11 3 373 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
oyster extract Crassostrea gigas inflammatory bowel disease experimental colitis microbiota short-chain fatty acid Chemical technology TP1-1185 |
spellingShingle |
oyster extract Crassostrea gigas inflammatory bowel disease experimental colitis microbiota short-chain fatty acid Chemical technology TP1-1185 Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Ryota Hosomi Takaki Shimono Seiji Kanda Toshimasa Nishiyama Kenji Fukunaga Munehiro Yoshida Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice |
topic_facet |
oyster extract Crassostrea gigas inflammatory bowel disease experimental colitis microbiota short-chain fatty acid Chemical technology TP1-1185 |
description |
Drugs for inflammatory bowel diseases can be associated with serious side effects, and the development of alternative candidate resources derived from natural products has attracted considerable attention. Oyster extract (OE) derived from Crassostrea gigas contains glycogen, taurine, and amino acids, and has been assigned diverse health-promoting properties. This study investigated the anti-colitis effect of OE intake on fecal microbiota and its metabolites of acute experimental colitis mouse model induced by dextran sulfate sodium (DSS). C57BL/6J mice (male) were divided into three groups: (1) American Institute of Nutrition (AIN) 93G diet + DSS-untreated, (2) AIN93G diet + DSS-treated, and (3) 5% OE diet + DSS-treated. Mice were fed each diet for 21 days, and then administered 2.5% DSS solution to induce acute colitis for 7 days. In DSS-induced colitis mice, OE decreased body weight loss and increased disease activity index during the DSS-induced period. In addition, OE tended to decrease the colon length shortening and the relative spleen weight and alleviated colonic tissue damage. Moreover, OE improved fecal short-chain fatty acids compositions and altered the structure of fecal microbiota. These results provide insight into the health-promoting property of OE in alleviating DSS-induced acute colitis, providing a basis for the development and use of functional foods. |
format |
Article in Journal/Newspaper |
author |
Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Ryota Hosomi Takaki Shimono Seiji Kanda Toshimasa Nishiyama Kenji Fukunaga Munehiro Yoshida |
author_facet |
Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Ryota Hosomi Takaki Shimono Seiji Kanda Toshimasa Nishiyama Kenji Fukunaga Munehiro Yoshida |
author_sort |
Tatsuya Ishida |
title |
Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice |
title_short |
Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice |
title_full |
Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice |
title_fullStr |
Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice |
title_full_unstemmed |
Oyster ( Crassostrea gigas ) Extract Attenuates Dextran Sulfate Sodium-Induced Acute Experimental Colitis by Improving Gut Microbiota and Short-Chain Fatty Acids Compositions in Mice |
title_sort |
oyster ( crassostrea gigas ) extract attenuates dextran sulfate sodium-induced acute experimental colitis by improving gut microbiota and short-chain fatty acids compositions in mice |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/foods11030373 https://doaj.org/article/14336674d99a4a5ba616f83c54231f6d |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Foods, Vol 11, Iss 373, p 373 (2022) |
op_relation |
https://www.mdpi.com/2304-8158/11/3/373 https://doaj.org/toc/2304-8158 doi:10.3390/foods11030373 2304-8158 https://doaj.org/article/14336674d99a4a5ba616f83c54231f6d |
op_doi |
https://doi.org/10.3390/foods11030373 |
container_title |
Foods |
container_volume |
11 |
container_issue |
3 |
container_start_page |
373 |
_version_ |
1766393434173603840 |