Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane p...
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ftdoajarticles:oai:doaj.org/article:1409524c1825421582d1f8976bedce9d 2023-05-15T15:05:36+02:00 Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression Isadora S Oliveira Isabela G Ferreira Gabriel M Alexandre-Silva Felipe A Cerni Caroline M Cremonez Eliane C Arantes Umberto Zottich Manuela B Pucca 2019-04-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-1481-18 https://doaj.org/article/1409524c1825421582d1f8976bedce9d EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-1481-18 https://doaj.org/article/1409524c1825421582d1f8976bedce9d Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 25, Iss 0 (2019) voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2019 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-1481-18 2022-12-31T03:53:17Z Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 25 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Isadora S Oliveira Isabela G Ferreira Gabriel M Alexandre-Silva Felipe A Cerni Caroline M Cremonez Eliane C Arantes Umberto Zottich Manuela B Pucca Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
topic_facet |
voltage-gated potassium channels Kv1.3 scorpion toxins KTx immunosuppression Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for their possible ability to control inflammatory autoimmune diseases. Some of these toxins have already left bench trials and are being evaluated in clinical trials, presenting great therapeutic potential. Thus, scorpion toxins are important natural molecules that should not be overlooked in the treatment of autoimmune and other diseases. |
format |
Article in Journal/Newspaper |
author |
Isadora S Oliveira Isabela G Ferreira Gabriel M Alexandre-Silva Felipe A Cerni Caroline M Cremonez Eliane C Arantes Umberto Zottich Manuela B Pucca |
author_facet |
Isadora S Oliveira Isabela G Ferreira Gabriel M Alexandre-Silva Felipe A Cerni Caroline M Cremonez Eliane C Arantes Umberto Zottich Manuela B Pucca |
author_sort |
Isadora S Oliveira |
title |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_short |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_full |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_fullStr |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_full_unstemmed |
Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression |
title_sort |
scorpion toxins targeting kv1.3 channels: insights into immunosuppression |
publisher |
SciELO |
publishDate |
2019 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-1481-18 https://doaj.org/article/1409524c1825421582d1f8976bedce9d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 25, Iss 0 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202&lng=en&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-1481-18 https://doaj.org/article/1409524c1825421582d1f8976bedce9d |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-1481-18 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
25 |
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1766337269306753024 |