Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India
Abstract Background Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children. Methods A prospective, observational study w...
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ftdoajarticles:oai:doaj.org/article:14058a572d6b412e843e28216c4d7209 2023-05-15T15:06:36+02:00 Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India Deepali Savargaonkar Manoj Kumar Das Amar Verma Jeevan K. Mitra C. P. Yadav Bina Srivastava Anupkumar R. Anvikar Neena Valecha 2020-01-01T00:00:00Z https://doi.org/10.1186/s12936-020-3120-4 https://doaj.org/article/14058a572d6b412e843e28216c4d7209 EN eng BMC https://doi.org/10.1186/s12936-020-3120-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-3120-4 1475-2875 https://doaj.org/article/14058a572d6b412e843e28216c4d7209 Malaria Journal, Vol 19, Iss 1, Pp 1-6 (2020) Severe malaria Injection artesunate Delayed haemolysis Haemoglobin Lactate dehydrogenase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-3120-4 2022-12-31T04:07:09Z Abstract Background Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children. Methods A prospective, observational study was carried out in admitted severe malaria patients receiving parenteral artesunate. The patients were followed up until day 28 for monitoring clinical as well as laboratory parameters for haemolytic anaemia. Results Twenty-four patients with severe malaria receiving injection artesunate were enrolled in the study. Post-artesunate delayed haemolysis following parenteral artesunate therapy was observed in three of 24 patients (12.5%, 95% confidence interval 4.5–31.2%). Haemolysis was observed in two more patients possibly due to other reasons. The haemoglobin fall ranged from 13.6 to 38.3% from day 7 to day 28 in these patients. Conclusion The possibility of delayed haemolysis should be considered while treating the severe malaria patients with parenteral artesunate. The study highlights the need for further studies in different epidemiological settings. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Severe malaria Injection artesunate Delayed haemolysis Haemoglobin Lactate dehydrogenase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Severe malaria Injection artesunate Delayed haemolysis Haemoglobin Lactate dehydrogenase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Deepali Savargaonkar Manoj Kumar Das Amar Verma Jeevan K. Mitra C. P. Yadav Bina Srivastava Anupkumar R. Anvikar Neena Valecha Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India |
topic_facet |
Severe malaria Injection artesunate Delayed haemolysis Haemoglobin Lactate dehydrogenase Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Parenteral artesunate is the treatment of choice for severe malaria. It is safe, efficacious and well tolerated anti-malarial. However, delayed haemolysis has been reported in travellers, non-immune individuals and in African children. Methods A prospective, observational study was carried out in admitted severe malaria patients receiving parenteral artesunate. The patients were followed up until day 28 for monitoring clinical as well as laboratory parameters for haemolytic anaemia. Results Twenty-four patients with severe malaria receiving injection artesunate were enrolled in the study. Post-artesunate delayed haemolysis following parenteral artesunate therapy was observed in three of 24 patients (12.5%, 95% confidence interval 4.5–31.2%). Haemolysis was observed in two more patients possibly due to other reasons. The haemoglobin fall ranged from 13.6 to 38.3% from day 7 to day 28 in these patients. Conclusion The possibility of delayed haemolysis should be considered while treating the severe malaria patients with parenteral artesunate. The study highlights the need for further studies in different epidemiological settings. |
format |
Article in Journal/Newspaper |
author |
Deepali Savargaonkar Manoj Kumar Das Amar Verma Jeevan K. Mitra C. P. Yadav Bina Srivastava Anupkumar R. Anvikar Neena Valecha |
author_facet |
Deepali Savargaonkar Manoj Kumar Das Amar Verma Jeevan K. Mitra C. P. Yadav Bina Srivastava Anupkumar R. Anvikar Neena Valecha |
author_sort |
Deepali Savargaonkar |
title |
Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India |
title_short |
Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India |
title_full |
Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India |
title_fullStr |
Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India |
title_full_unstemmed |
Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India |
title_sort |
delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in india |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-3120-4 https://doaj.org/article/14058a572d6b412e843e28216c4d7209 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-6 (2020) |
op_relation |
https://doi.org/10.1186/s12936-020-3120-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-3120-4 1475-2875 https://doaj.org/article/14058a572d6b412e843e28216c4d7209 |
op_doi |
https://doi.org/10.1186/s12936-020-3120-4 |
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Malaria Journal |
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19 |
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1 |
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1766338173340745728 |