Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis.
Rheumatic heart disease (RHD) continues to affect developing countries with low income due to the lack of resources and effective diagnostic techniques. Understanding the genetic basis common to both the diseases and that of progression from its prequel disease state, Acute Rheumatic Fever (ARF), wo...
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ftdoajarticles:oai:doaj.org/article:1401e00161db4c2f8adaf7527e4d36d6 2023-06-11T04:09:36+02:00 Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. Ranjitha Guttapadu Nandini Prakash Alka M Ritika Chatterjee Mahantesh S Jayranganath M Usha Mk Sastry Jayshree Rudrapatna Subramanyam Dipshikha Chakravortty Kalpana S R Nagasuma Chandra 2023-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011263 https://doaj.org/article/1401e00161db4c2f8adaf7527e4d36d6 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011263 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011263 https://doaj.org/article/1401e00161db4c2f8adaf7527e4d36d6 PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011263 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011263 2023-05-07T00:31:57Z Rheumatic heart disease (RHD) continues to affect developing countries with low income due to the lack of resources and effective diagnostic techniques. Understanding the genetic basis common to both the diseases and that of progression from its prequel disease state, Acute Rheumatic Fever (ARF), would aid in developing predictive biomarkers and improving patient care. To gain system-wide molecular insights into possible causes for progression, in this pilot study, we collected blood transcriptomes from ARF (5) and RHD (5) patients. Using an integrated transcriptome and network analysis approach, we identified a subnetwork comprising the most significantly differentially expressed genes and most perturbed pathways in RHD compared to ARF. For example, the chemokine signaling pathway was seen to be upregulated, while tryptophan metabolism was found to be downregulated in RHD. The subnetworks of variation between the two conditions provide unbiased molecular-level insights into the host processes that may be linked with the progression of ARF to RHD, which has the potential to inform future diagnostics and therapeutic strategies. We also found a significantly raised neutrophil/lymphocyte ratio in both ARF and RHD cohorts. Activated neutrophils and inhibited Natural Killer cell gene signatures reflected the drivers of the inflammatory process typical to both disease conditions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 4 e0011263 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ranjitha Guttapadu Nandini Prakash Alka M Ritika Chatterjee Mahantesh S Jayranganath M Usha Mk Sastry Jayshree Rudrapatna Subramanyam Dipshikha Chakravortty Kalpana S R Nagasuma Chandra Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Rheumatic heart disease (RHD) continues to affect developing countries with low income due to the lack of resources and effective diagnostic techniques. Understanding the genetic basis common to both the diseases and that of progression from its prequel disease state, Acute Rheumatic Fever (ARF), would aid in developing predictive biomarkers and improving patient care. To gain system-wide molecular insights into possible causes for progression, in this pilot study, we collected blood transcriptomes from ARF (5) and RHD (5) patients. Using an integrated transcriptome and network analysis approach, we identified a subnetwork comprising the most significantly differentially expressed genes and most perturbed pathways in RHD compared to ARF. For example, the chemokine signaling pathway was seen to be upregulated, while tryptophan metabolism was found to be downregulated in RHD. The subnetworks of variation between the two conditions provide unbiased molecular-level insights into the host processes that may be linked with the progression of ARF to RHD, which has the potential to inform future diagnostics and therapeutic strategies. We also found a significantly raised neutrophil/lymphocyte ratio in both ARF and RHD cohorts. Activated neutrophils and inhibited Natural Killer cell gene signatures reflected the drivers of the inflammatory process typical to both disease conditions. |
format |
Article in Journal/Newspaper |
author |
Ranjitha Guttapadu Nandini Prakash Alka M Ritika Chatterjee Mahantesh S Jayranganath M Usha Mk Sastry Jayshree Rudrapatna Subramanyam Dipshikha Chakravortty Kalpana S R Nagasuma Chandra |
author_facet |
Ranjitha Guttapadu Nandini Prakash Alka M Ritika Chatterjee Mahantesh S Jayranganath M Usha Mk Sastry Jayshree Rudrapatna Subramanyam Dipshikha Chakravortty Kalpana S R Nagasuma Chandra |
author_sort |
Ranjitha Guttapadu |
title |
Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. |
title_short |
Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. |
title_full |
Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. |
title_fullStr |
Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. |
title_full_unstemmed |
Profiling system-wide variations and similarities between Rheumatic Heart Disease and Acute Rheumatic Fever-A pilot analysis. |
title_sort |
profiling system-wide variations and similarities between rheumatic heart disease and acute rheumatic fever-a pilot analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011263 https://doaj.org/article/1401e00161db4c2f8adaf7527e4d36d6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 4, p e0011263 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011263 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011263 https://doaj.org/article/1401e00161db4c2f8adaf7527e4d36d6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011263 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
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4 |
container_start_page |
e0011263 |
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1768383567071543296 |