The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis.
Background As the three major arthropod-borne viruses, dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV) are posing a growing threat to global public health and socioeconomic development. Our study aimed to systematically review the global seroprevalences of these arboviruses fro...
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ftdoajarticles:oai:doaj.org/article:13fe4319e3d94fa2806f773d4fedf3f4 2023-05-15T15:14:11+02:00 The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. Zhihui Li Jin Wang Xiaomin Cheng Huan Hu Cheng Guo Jingyi Huang Zeliang Chen Jiahai Lu 2021-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009337 https://doaj.org/article/13fe4319e3d94fa2806f773d4fedf3f4 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009337 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009337 https://doaj.org/article/13fe4319e3d94fa2806f773d4fedf3f4 PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009337 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009337 2022-12-31T13:13:07Z Background As the three major arthropod-borne viruses, dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV) are posing a growing threat to global public health and socioeconomic development. Our study aimed to systematically review the global seroprevalences of these arboviruses from existing publications. Methods Articles published between Jan 01, 2000 and Dec 31, 2019 in the databases of Embase, Pubmed and Web of Science were searched and collected. Countries or areas with known local presence of Aedes vector mosquitoes were included. Random effects model was utilized to estimate the pooled seroprevalences and the proportion of inapparent infection. Results Out of 1375, a total of 133 articles involving 176,001 subjects were included for our analysis. The pooled seroprevalences of DENV, CHIKV and ZIKV were 38%, 25% and 18%, respectively; and their corresponding proportions of inapparent infections were 80%, 40% and 50%. The South-East Asia Region had the highest seroprevalences of DENV and CHIKV, while the Region of the Americas had the highest seroprevalence of ZIKV. The seroprevalences of DENV and CHIKV were similar when comparing developed and developing countries, urban and rural areas, or among different populations. In addition, we observed a decreased global seroprevalences in the new decade (2010-2019) comparing to the decade before (2000-2009) for CHIKV. For ZIKV, the positive rates tested with the nucleic acid detection method were lower than those tested with the antibody detection method. Lastly, numerous cases of dual seropositivity for CHIKV and DENV were reported. Conclusions Our results revealed a varied prevalence of arbovirus infections in different geographical regions and countries, and the inapparent infection accounted an unneglected portion of infections that requires more attention. This study will shed lights on our understanding of the true burden of arbovirus infections and promote appropriate vaccination in the future. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 4 e0009337 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zhihui Li Jin Wang Xiaomin Cheng Huan Hu Cheng Guo Jingyi Huang Zeliang Chen Jiahai Lu The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background As the three major arthropod-borne viruses, dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV) are posing a growing threat to global public health and socioeconomic development. Our study aimed to systematically review the global seroprevalences of these arboviruses from existing publications. Methods Articles published between Jan 01, 2000 and Dec 31, 2019 in the databases of Embase, Pubmed and Web of Science were searched and collected. Countries or areas with known local presence of Aedes vector mosquitoes were included. Random effects model was utilized to estimate the pooled seroprevalences and the proportion of inapparent infection. Results Out of 1375, a total of 133 articles involving 176,001 subjects were included for our analysis. The pooled seroprevalences of DENV, CHIKV and ZIKV were 38%, 25% and 18%, respectively; and their corresponding proportions of inapparent infections were 80%, 40% and 50%. The South-East Asia Region had the highest seroprevalences of DENV and CHIKV, while the Region of the Americas had the highest seroprevalence of ZIKV. The seroprevalences of DENV and CHIKV were similar when comparing developed and developing countries, urban and rural areas, or among different populations. In addition, we observed a decreased global seroprevalences in the new decade (2010-2019) comparing to the decade before (2000-2009) for CHIKV. For ZIKV, the positive rates tested with the nucleic acid detection method were lower than those tested with the antibody detection method. Lastly, numerous cases of dual seropositivity for CHIKV and DENV were reported. Conclusions Our results revealed a varied prevalence of arbovirus infections in different geographical regions and countries, and the inapparent infection accounted an unneglected portion of infections that requires more attention. This study will shed lights on our understanding of the true burden of arbovirus infections and promote appropriate vaccination in the future. |
format |
Article in Journal/Newspaper |
author |
Zhihui Li Jin Wang Xiaomin Cheng Huan Hu Cheng Guo Jingyi Huang Zeliang Chen Jiahai Lu |
author_facet |
Zhihui Li Jin Wang Xiaomin Cheng Huan Hu Cheng Guo Jingyi Huang Zeliang Chen Jiahai Lu |
author_sort |
Zhihui Li |
title |
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. |
title_short |
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. |
title_full |
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. |
title_fullStr |
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. |
title_full_unstemmed |
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis. |
title_sort |
worldwide seroprevalence of denv, chikv and zikv infection: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009337 https://doaj.org/article/13fe4319e3d94fa2806f773d4fedf3f4 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009337 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009337 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009337 https://doaj.org/article/13fe4319e3d94fa2806f773d4fedf3f4 |
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https://doi.org/10.1371/journal.pntd.0009337 |
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PLOS Neglected Tropical Diseases |
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e0009337 |
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