Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC)....
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ftdoajarticles:oai:doaj.org/article:13e1af771c80490ebb23acdf7b3c68b7 2024-09-09T19:26:22+00:00 Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga Angelina M.B. Bilate Edecio Cunha-Neto 2008-04-01T00:00:00Z https://doi.org/10.1590/S0036-46652008000200001 https://doaj.org/article/13e1af771c80490ebb23acdf7b3c68b7 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000200001 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652008000200001 0036-4665 1678-9946 https://doaj.org/article/13e1af771c80490ebb23acdf7b3c68b7 Revista do Instituto de Medicina Tropical de São Paulo, Vol 50, Iss 2, Pp 67-74 (2008) Chagas disease Cardiomyopathy Autoimmune disease Pathogenesis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1590/S0036-46652008000200001 2024-08-05T17:49:30Z Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy. A doença de Chagas continua sendo importante problema de saúde pública uma vez que cerca de 10 milhões de indivíduos ainda estão infectados pelo T. cruzi. Décadas após a infecção primária, aproximadamente 30% dos indivíduos podem desenvolver uma cardiomiopatia inflamatória crônica, a chamada Cardiomiopatia Chagásica Crônica (CCC). Dados de modelos murinos e de estudos em humanos apóiam a visão de que tanto respostas auto-imunes como as determinadas pelo parasita em conjunto com citocinas e quimiocinas inflamatórias participam da geração das lesões cardíacas típicas da CCC. A presente revisão tem como objetivo sumarizar os recentes avanços no entendimento da imunopatogênese da Cardiomiopatia Chagásica Crônica. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 50 2 67 74 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas disease Cardiomyopathy Autoimmune disease Pathogenesis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Chagas disease Cardiomyopathy Autoimmune disease Pathogenesis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Angelina M.B. Bilate Edecio Cunha-Neto Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga |
topic_facet |
Chagas disease Cardiomyopathy Autoimmune disease Pathogenesis Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy. A doença de Chagas continua sendo importante problema de saúde pública uma vez que cerca de 10 milhões de indivíduos ainda estão infectados pelo T. cruzi. Décadas após a infecção primária, aproximadamente 30% dos indivíduos podem desenvolver uma cardiomiopatia inflamatória crônica, a chamada Cardiomiopatia Chagásica Crônica (CCC). Dados de modelos murinos e de estudos em humanos apóiam a visão de que tanto respostas auto-imunes como as determinadas pelo parasita em conjunto com citocinas e quimiocinas inflamatórias participam da geração das lesões cardíacas típicas da CCC. A presente revisão tem como objetivo sumarizar os recentes avanços no entendimento da imunopatogênese da Cardiomiopatia Chagásica Crônica. |
format |
Article in Journal/Newspaper |
author |
Angelina M.B. Bilate Edecio Cunha-Neto |
author_facet |
Angelina M.B. Bilate Edecio Cunha-Neto |
author_sort |
Angelina M.B. Bilate |
title |
Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga |
title_short |
Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga |
title_full |
Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga |
title_fullStr |
Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga |
title_full_unstemmed |
Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga |
title_sort |
chagas disease cardiomyopathy: current concepts of an old disease cardiomiopatia chagásica: conceitos atuais de doença antiga |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2008 |
url |
https://doi.org/10.1590/S0036-46652008000200001 https://doaj.org/article/13e1af771c80490ebb23acdf7b3c68b7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 50, Iss 2, Pp 67-74 (2008) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652008000200001 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652008000200001 0036-4665 1678-9946 https://doaj.org/article/13e1af771c80490ebb23acdf7b3c68b7 |
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https://doi.org/10.1590/S0036-46652008000200001 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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50 |
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67 |
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74 |
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