Central nervous system infection in a pediatric population in West Java.
Central nervous system (CNS) viral infections are critical causes of morbidity and mortality in children; however, comprehensive data on etiology is lacking in developing countries such as Indonesia. To study the etiology of CNS infections in a pediatric population, 50 children admitted to two hospi...
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ftdoajarticles:oai:doaj.org/article:13a618bf7a064ddda55b18df06719ca5 2024-01-28T10:03:51+01:00 Central nervous system infection in a pediatric population in West Java. Dewi H Alisjahbana Syndi Nurmawati Mia Milanti Hofiya Djauhari Jeremy P Ledermann Ungke Antonjaya Yora Permata Dewi Edison Johar Ageng Wiyatno Ida Yus Sriyani Bachti Alisjahbana Dodi Safari Khin Saw Aye Myint Ann M Powers Dzulfikar Dl Hakim 2023-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011769 https://doaj.org/article/13a618bf7a064ddda55b18df06719ca5 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011769&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011769 https://doaj.org/article/13a618bf7a064ddda55b18df06719ca5 PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011769 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011769 2023-12-31T01:49:22Z Central nervous system (CNS) viral infections are critical causes of morbidity and mortality in children; however, comprehensive data on etiology is lacking in developing countries such as Indonesia. To study the etiology of CNS infections in a pediatric population, 50 children admitted to two hospitals in Bandung, West Java, during 2017-2018 were enrolled in a CNS infection study. Cerebrospinal fluid and serum specimens were tested using molecular, serological, and virus isolation platforms for a number of viral and bacteriological agents. Causal pathogens were identified in 10 out of 50 (20%) and included cytomegalovirus (n = 4), Streptococcus pneumoniae (n = 2), tuberculosis (n = 2), Salmonella serotype Typhi (n = 1) and dengue virus (n = 1). Our study highlights the importance of using a wide range of molecular and serological detection methods to identify CNS pathogens, as well as the challenges of establishing the etiology of CNS infections in pediatric populations of countries with limited laboratory capacity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 11 e0011769 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Dewi H Alisjahbana Syndi Nurmawati Mia Milanti Hofiya Djauhari Jeremy P Ledermann Ungke Antonjaya Yora Permata Dewi Edison Johar Ageng Wiyatno Ida Yus Sriyani Bachti Alisjahbana Dodi Safari Khin Saw Aye Myint Ann M Powers Dzulfikar Dl Hakim Central nervous system infection in a pediatric population in West Java. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Central nervous system (CNS) viral infections are critical causes of morbidity and mortality in children; however, comprehensive data on etiology is lacking in developing countries such as Indonesia. To study the etiology of CNS infections in a pediatric population, 50 children admitted to two hospitals in Bandung, West Java, during 2017-2018 were enrolled in a CNS infection study. Cerebrospinal fluid and serum specimens were tested using molecular, serological, and virus isolation platforms for a number of viral and bacteriological agents. Causal pathogens were identified in 10 out of 50 (20%) and included cytomegalovirus (n = 4), Streptococcus pneumoniae (n = 2), tuberculosis (n = 2), Salmonella serotype Typhi (n = 1) and dengue virus (n = 1). Our study highlights the importance of using a wide range of molecular and serological detection methods to identify CNS pathogens, as well as the challenges of establishing the etiology of CNS infections in pediatric populations of countries with limited laboratory capacity. |
format |
Article in Journal/Newspaper |
author |
Dewi H Alisjahbana Syndi Nurmawati Mia Milanti Hofiya Djauhari Jeremy P Ledermann Ungke Antonjaya Yora Permata Dewi Edison Johar Ageng Wiyatno Ida Yus Sriyani Bachti Alisjahbana Dodi Safari Khin Saw Aye Myint Ann M Powers Dzulfikar Dl Hakim |
author_facet |
Dewi H Alisjahbana Syndi Nurmawati Mia Milanti Hofiya Djauhari Jeremy P Ledermann Ungke Antonjaya Yora Permata Dewi Edison Johar Ageng Wiyatno Ida Yus Sriyani Bachti Alisjahbana Dodi Safari Khin Saw Aye Myint Ann M Powers Dzulfikar Dl Hakim |
author_sort |
Dewi H Alisjahbana |
title |
Central nervous system infection in a pediatric population in West Java. |
title_short |
Central nervous system infection in a pediatric population in West Java. |
title_full |
Central nervous system infection in a pediatric population in West Java. |
title_fullStr |
Central nervous system infection in a pediatric population in West Java. |
title_full_unstemmed |
Central nervous system infection in a pediatric population in West Java. |
title_sort |
central nervous system infection in a pediatric population in west java. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011769 https://doaj.org/article/13a618bf7a064ddda55b18df06719ca5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011769 (2023) |
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https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011769&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011769 https://doaj.org/article/13a618bf7a064ddda55b18df06719ca5 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011769 |
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PLOS Neglected Tropical Diseases |
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17 |
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11 |
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e0011769 |
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