Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use
Objective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria. Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malari...
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Wolters Kluwer Medknow Publications
2015
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ftdoajarticles:oai:doaj.org/article:139f59b946e449658ce1ab7c4fe5fed3 2023-05-15T15:03:15+02:00 Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier 2015-12-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.09.002 https://doaj.org/article/139f59b946e449658ce1ab7c4fe5fed3 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002142 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.002 https://doaj.org/article/139f59b946e449658ce1ab7c4fe5fed3 Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 12, Pp 982-986 (2015) Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.09.002 2022-12-31T11:20:58Z Objective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria. Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi. Results: The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro (IC50 0.74 mg/mL), a therapeutic index of 9.54. In mice treated with the aqueous extract (2000 mg/kg/day), peak parasitaemia values were 81% lower in the experimental 2.35% ± 0.14% as compared to controls 12.62% ± 0.52% (P < 0.001), suggesting significant prophylactic activity. Conclusions: The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 12 982 986 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
topic_facet |
Polyherbal remedy Plasmodium Malaria prophylaxis Antiplasmodial activity Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the potential prophylactic activity of traditional polyherbal remedy against malaria. Methods: A traditional polyherbal remedy against malaria from Odisha, India was evaluated for its potential prophylactic activity using in vitro hepatic cell lines assay and the murine malaria system Plasmodium yoelii yoelii/Anopheles stephensi. Results: The polyherbal extract inhibited the Plasmodium yoelii hepatic stages in vitro (IC50 0.74 mg/mL), a therapeutic index of 9.54. In mice treated with the aqueous extract (2000 mg/kg/day), peak parasitaemia values were 81% lower in the experimental 2.35% ± 0.14% as compared to controls 12.62% ± 0.52% (P < 0.001), suggesting significant prophylactic activity. Conclusions: The observations provide a proof of concept for a traditional malaria prophylactic remedy used by tribal populations in India. |
format |
Article in Journal/Newspaper |
author |
Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier |
author_facet |
Prakash Bangalore Nagendrappa Jean-François Franetich Frederick Gay Audrey Lorthiois Padma Venkatasubramanian Dominique Mazier |
author_sort |
Prakash Bangalore Nagendrappa |
title |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_short |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_full |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_fullStr |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_full_unstemmed |
Antiplasmodial activity of traditional polyherbal remedy from Odisha, India: Their potential for prophylactic use |
title_sort |
antiplasmodial activity of traditional polyherbal remedy from odisha, india: their potential for prophylactic use |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.apjtb.2015.09.002 https://doaj.org/article/139f59b946e449658ce1ab7c4fe5fed3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 12, Pp 982-986 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002142 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.002 https://doaj.org/article/139f59b946e449658ce1ab7c4fe5fed3 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.09.002 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
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5 |
container_issue |
12 |
container_start_page |
982 |
op_container_end_page |
986 |
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1766335132870901760 |