Detection of bla KPC-2 in Proteus mirabilis in Brazil
INTRODUCTION : Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today. METHODS : A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes. RESU...
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Online Access: | https://doi.org/10.1590/0037-8682-0152-2014 https://doaj.org/article/13987403fc2f4b6cbaaa6b8a5251d471 |
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ftdoajarticles:oai:doaj.org/article:13987403fc2f4b6cbaaa6b8a5251d471 2023-05-15T15:02:56+02:00 Detection of bla KPC-2 in Proteus mirabilis in Brazil Adriane Borges Cabral Maria Amélia Vieira Maciel Josineide Ferreira Barros Marcelo Maranhão Antunes Ana Catarina Souza Lopes 2015-02-01T00:00:00Z https://doi.org/10.1590/0037-8682-0152-2014 https://doaj.org/article/13987403fc2f4b6cbaaa6b8a5251d471 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100094&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0152-2014 https://doaj.org/article/13987403fc2f4b6cbaaa6b8a5251d471 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 1, Pp 94-95 (2015) Proteus mirabilis blaKPC-2 Plasmid DNA Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0152-2014 2022-12-31T02:52:50Z INTRODUCTION : Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today. METHODS : A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes. RESULTS : The isolate exhibited resistance to ertapenem and imipenem and was susceptible to meropenem, polymyxin, and tigecycline. Five plasmids were identified in this isolate. DNA sequencing analysis revealed the presence of bla KPC-2 and bla TEM-1 genes. An additional PCR using plasmid DNA confirmed that bla KPC-2 was present in one of these plasmids. Conclusions: We report the detection of bla KPC-2 in P. mirabilis in Brazil for the first time. This finding highlights the continuous transfer of bla KPC between bacterial genera, which presents a serious challenge to the prevention of infection by multidrug-resistant bacteria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 48 1 94 95 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Proteus mirabilis blaKPC-2 Plasmid DNA Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Proteus mirabilis blaKPC-2 Plasmid DNA Arctic medicine. Tropical medicine RC955-962 Adriane Borges Cabral Maria Amélia Vieira Maciel Josineide Ferreira Barros Marcelo Maranhão Antunes Ana Catarina Souza Lopes Detection of bla KPC-2 in Proteus mirabilis in Brazil |
topic_facet |
Proteus mirabilis blaKPC-2 Plasmid DNA Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION : Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today. METHODS : A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes. RESULTS : The isolate exhibited resistance to ertapenem and imipenem and was susceptible to meropenem, polymyxin, and tigecycline. Five plasmids were identified in this isolate. DNA sequencing analysis revealed the presence of bla KPC-2 and bla TEM-1 genes. An additional PCR using plasmid DNA confirmed that bla KPC-2 was present in one of these plasmids. Conclusions: We report the detection of bla KPC-2 in P. mirabilis in Brazil for the first time. This finding highlights the continuous transfer of bla KPC between bacterial genera, which presents a serious challenge to the prevention of infection by multidrug-resistant bacteria. |
format |
Article in Journal/Newspaper |
author |
Adriane Borges Cabral Maria Amélia Vieira Maciel Josineide Ferreira Barros Marcelo Maranhão Antunes Ana Catarina Souza Lopes |
author_facet |
Adriane Borges Cabral Maria Amélia Vieira Maciel Josineide Ferreira Barros Marcelo Maranhão Antunes Ana Catarina Souza Lopes |
author_sort |
Adriane Borges Cabral |
title |
Detection of bla KPC-2 in Proteus mirabilis in Brazil |
title_short |
Detection of bla KPC-2 in Proteus mirabilis in Brazil |
title_full |
Detection of bla KPC-2 in Proteus mirabilis in Brazil |
title_fullStr |
Detection of bla KPC-2 in Proteus mirabilis in Brazil |
title_full_unstemmed |
Detection of bla KPC-2 in Proteus mirabilis in Brazil |
title_sort |
detection of bla kpc-2 in proteus mirabilis in brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0152-2014 https://doaj.org/article/13987403fc2f4b6cbaaa6b8a5251d471 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 1, Pp 94-95 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100094&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0152-2014 https://doaj.org/article/13987403fc2f4b6cbaaa6b8a5251d471 |
op_doi |
https://doi.org/10.1590/0037-8682-0152-2014 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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48 |
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95 |
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