Lymphopenia and lymphocytosis in practical healthy people born and living in the North
Abstract Introduction The purpose of this study was to elucidate the mechanisms of the formation of lymphopenia and lymphocytosis in healthy people, who are living and working in the Arctic region. Materials and Methods A total of 88 practically healthy people living and working in the Arctic region...
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ftdoajarticles:oai:doaj.org/article:1388b52da7844d1eb0ce5dc978627957 2023-05-15T14:55:37+02:00 Lymphopenia and lymphocytosis in practical healthy people born and living in the North Veronika P. Patrakeeva Liliya K. Dobrodeeva 2020-09-01T00:00:00Z https://doi.org/10.1002/iid3.308 https://doaj.org/article/1388b52da7844d1eb0ce5dc978627957 EN eng Wiley https://doi.org/10.1002/iid3.308 https://doaj.org/toc/2050-4527 2050-4527 doi:10.1002/iid3.308 https://doaj.org/article/1388b52da7844d1eb0ce5dc978627957 Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 320-324 (2020) G‐CSF lymphocytosis lymphopenia neutropenia NFATc1 Immunologic diseases. Allergy RC581-607 article 2020 ftdoajarticles https://doi.org/10.1002/iid3.308 2022-12-31T09:47:00Z Abstract Introduction The purpose of this study was to elucidate the mechanisms of the formation of lymphopenia and lymphocytosis in healthy people, who are living and working in the Arctic region. Materials and Methods A total of 88 practically healthy people living and working in the Arctic region were examined. An analysis of the results was carried out, depending on the concentration of lymphocytes in the peripheral venous blood: group 1—with lymphopenia, the content of lymphocytes below 1.5 × 109cl/L (21 people); group 2—with a normal lymphocyte content from 1.5 to 3.5 × 109cl/L (47 people); and group 3—with lymphocytosis, lymphocytes in the peripheral blood of more than 3.5 × 109cl/L (20 people). Results It has been established that the main mechanism for the formation of lymphopenia in a person living in the Arctic is the activation of the migration of functionally active lymphocytes in the tissue. The decrease in the number of circulating lymphocytes is a consequence of their redistribution from the circulating pool to the marginal one and an increase in the activity of adhesive molecules, in particular, the selectin ligand. It was revealed that an increase in the content of lymphocytes in the blood occurs upon the activation of the intracellular energy‐intensive mechanisms of lymphoproliferation with an increase in the consumption of intracellular ATP and the participation of the nuclear factor of activated T cells 1. It was shown that the restoration of the circulating pool of mature neutrophils is ensured by the principle of reverse regulation in response to neutropenia by stimulating granulocyte‐colony stimulating factor granulopoiesis. Conclusions The main mechanism for the formation of lymphopenia and lymphocytosis in healthy people was established. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Immunity, Inflammation and Disease 8 3 320 324 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
G‐CSF lymphocytosis lymphopenia neutropenia NFATc1 Immunologic diseases. Allergy RC581-607 |
spellingShingle |
G‐CSF lymphocytosis lymphopenia neutropenia NFATc1 Immunologic diseases. Allergy RC581-607 Veronika P. Patrakeeva Liliya K. Dobrodeeva Lymphopenia and lymphocytosis in practical healthy people born and living in the North |
topic_facet |
G‐CSF lymphocytosis lymphopenia neutropenia NFATc1 Immunologic diseases. Allergy RC581-607 |
description |
Abstract Introduction The purpose of this study was to elucidate the mechanisms of the formation of lymphopenia and lymphocytosis in healthy people, who are living and working in the Arctic region. Materials and Methods A total of 88 practically healthy people living and working in the Arctic region were examined. An analysis of the results was carried out, depending on the concentration of lymphocytes in the peripheral venous blood: group 1—with lymphopenia, the content of lymphocytes below 1.5 × 109cl/L (21 people); group 2—with a normal lymphocyte content from 1.5 to 3.5 × 109cl/L (47 people); and group 3—with lymphocytosis, lymphocytes in the peripheral blood of more than 3.5 × 109cl/L (20 people). Results It has been established that the main mechanism for the formation of lymphopenia in a person living in the Arctic is the activation of the migration of functionally active lymphocytes in the tissue. The decrease in the number of circulating lymphocytes is a consequence of their redistribution from the circulating pool to the marginal one and an increase in the activity of adhesive molecules, in particular, the selectin ligand. It was revealed that an increase in the content of lymphocytes in the blood occurs upon the activation of the intracellular energy‐intensive mechanisms of lymphoproliferation with an increase in the consumption of intracellular ATP and the participation of the nuclear factor of activated T cells 1. It was shown that the restoration of the circulating pool of mature neutrophils is ensured by the principle of reverse regulation in response to neutropenia by stimulating granulocyte‐colony stimulating factor granulopoiesis. Conclusions The main mechanism for the formation of lymphopenia and lymphocytosis in healthy people was established. |
format |
Article in Journal/Newspaper |
author |
Veronika P. Patrakeeva Liliya K. Dobrodeeva |
author_facet |
Veronika P. Patrakeeva Liliya K. Dobrodeeva |
author_sort |
Veronika P. Patrakeeva |
title |
Lymphopenia and lymphocytosis in practical healthy people born and living in the North |
title_short |
Lymphopenia and lymphocytosis in practical healthy people born and living in the North |
title_full |
Lymphopenia and lymphocytosis in practical healthy people born and living in the North |
title_fullStr |
Lymphopenia and lymphocytosis in practical healthy people born and living in the North |
title_full_unstemmed |
Lymphopenia and lymphocytosis in practical healthy people born and living in the North |
title_sort |
lymphopenia and lymphocytosis in practical healthy people born and living in the north |
publisher |
Wiley |
publishDate |
2020 |
url |
https://doi.org/10.1002/iid3.308 https://doaj.org/article/1388b52da7844d1eb0ce5dc978627957 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 320-324 (2020) |
op_relation |
https://doi.org/10.1002/iid3.308 https://doaj.org/toc/2050-4527 2050-4527 doi:10.1002/iid3.308 https://doaj.org/article/1388b52da7844d1eb0ce5dc978627957 |
op_doi |
https://doi.org/10.1002/iid3.308 |
container_title |
Immunity, Inflammation and Disease |
container_volume |
8 |
container_issue |
3 |
container_start_page |
320 |
op_container_end_page |
324 |
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1766327646268948480 |