Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice
Objective: To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice. Methods: AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%, respectively. Clinical symptoms and histologica...
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Wolters Kluwer Medknow Publications
2022
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ftdoajarticles:oai:doaj.org/article:1370408501aa42c881b2f8a872bf06e9 2023-05-15T15:06:42+02:00 Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice Fardin Khajepour Mohammad Reza Zangouyee Arezu Khosravimashizi Ali Afgar Vahideh Abdollahi Shahriar Dabiri Reza Nosratabadi 2022-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.357741 https://doaj.org/article/1370408501aa42c881b2f8a872bf06e9 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=10;spage=421;epage=429;aulast=Khajepour https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.357741 https://doaj.org/article/1370408501aa42c881b2f8a872bf06e9 Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 10, Pp 421-429 (2022) carum carvi l. caraway atopic dermatitis 2 4 dinitrochlorobenzene th2 th1 oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.4103/2221-1691.357741 2022-12-30T22:40:09Z Objective: To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice. Methods: AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%, respectively. Clinical symptoms and histological analysis of the skin were assessed. The effects of caraway on oxidant/antioxidant parameters as well as Th1- and Th2-related cytokines were also evaluated. Results: Caraway reduced the severity of dermatitis in AD-induced mice, as evidenced by significant inhibition of Th2-related cytokines (IL-4 and IL-13) and increased Th1-related cytokine (IFN-γ). Additionally, treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD mice. Furthermore, caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and T-bet. Conclusions: Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 12 10 421 |
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Directory of Open Access Journals: DOAJ Articles |
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carum carvi l. caraway atopic dermatitis 2 4 dinitrochlorobenzene th2 th1 oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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carum carvi l. caraway atopic dermatitis 2 4 dinitrochlorobenzene th2 th1 oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Fardin Khajepour Mohammad Reza Zangouyee Arezu Khosravimashizi Ali Afgar Vahideh Abdollahi Shahriar Dabiri Reza Nosratabadi Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice |
topic_facet |
carum carvi l. caraway atopic dermatitis 2 4 dinitrochlorobenzene th2 th1 oxidative stress Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice. Methods: AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%, respectively. Clinical symptoms and histological analysis of the skin were assessed. The effects of caraway on oxidant/antioxidant parameters as well as Th1- and Th2-related cytokines were also evaluated. Results: Caraway reduced the severity of dermatitis in AD-induced mice, as evidenced by significant inhibition of Th2-related cytokines (IL-4 and IL-13) and increased Th1-related cytokine (IFN-γ). Additionally, treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD mice. Furthermore, caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and T-bet. Conclusions: Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease. |
format |
Article in Journal/Newspaper |
author |
Fardin Khajepour Mohammad Reza Zangouyee Arezu Khosravimashizi Ali Afgar Vahideh Abdollahi Shahriar Dabiri Reza Nosratabadi |
author_facet |
Fardin Khajepour Mohammad Reza Zangouyee Arezu Khosravimashizi Ali Afgar Vahideh Abdollahi Shahriar Dabiri Reza Nosratabadi |
author_sort |
Fardin Khajepour |
title |
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice |
title_short |
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice |
title_full |
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice |
title_fullStr |
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice |
title_full_unstemmed |
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice |
title_sort |
caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing th2 cells, and upregulating th1 cells in mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/2221-1691.357741 https://doaj.org/article/1370408501aa42c881b2f8a872bf06e9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 10, Pp 421-429 (2022) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=10;spage=421;epage=429;aulast=Khajepour https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.357741 https://doaj.org/article/1370408501aa42c881b2f8a872bf06e9 |
op_doi |
https://doi.org/10.4103/2221-1691.357741 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
12 |
container_issue |
10 |
container_start_page |
421 |
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1766338256657448960 |