Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Authors: Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2018
• Subjects: Neurorrhaphy; Sciatic nerve; Human embryonic stem cells; Fibrin sealant; FGF2; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic; Catwalk
• Online Access: https://doi.org/10.1186/s40409-018-0147-x; https://doaj.org/article/135813bc2517467a88f37c6d00130c01

Abstract Background Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used. However, these surgical techniques result in nerve regen...