Retention of testicular integrity and testosterone levels upon ingestion of garlic cloves (Allium sativum) in the Sprague-Dawley rat

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Adejoke Elizabeth Memudu, Ibukun Dorcas Akinrinade, Olalekan Michael Ogundele
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015
• Subjects: Allium sativum; Testis; Testosterone; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.1016/S2221-1691(15)30351-8; https://doaj.org/article/133fa08230ed4ecf8380a8754b62d319

Objective: To investigate the effects of acute and chronic aqueous garlic extract ingestion on testicular cellular integrity and serum testosterone levels. Methods: Twenty (20) male Sprague-Dawley rats weighing an average of 120 g were used. Animals were divided into three groups. Group A served as control (10 rats for 28 and 56 d respectively), while treatment Groups B and C were given 200 mg/kg for Allium sativum (garlic cloves) extract for 28 and 56 d respectively. Results: Histological analysis revealed the presence of all spermatogenic lineages, appearance of proliferative activities in the interstitial cells, as well as increased serum testosterone levels. Conclusions: This study confirmed proliferative and restorative potentials in both acute and chronic garlic ingestion.