NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity
Abstract Background Neutrophil cytosolic factor 1, p47 phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types o...
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ftdoajarticles:oai:doaj.org/article:1323eb71bda04730b89e0e58a16fafc9 2023-05-15T15:04:05+02:00 NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity Selmaj Krysztof W Mycko Marcin P Lell Bertrand Kun Jürgen Vonthein Reinhard Hoffmann Peter Greve Bernhard Berger Klaus Weissert Robert Kremsner Peter G 2008-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-251 https://doaj.org/article/1323eb71bda04730b89e0e58a16fafc9 EN eng BMC http://www.malariajournal.com/content/7/1/251 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-251 1475-2875 https://doaj.org/article/1323eb71bda04730b89e0e58a16fafc9 Malaria Journal, Vol 7, Iss 1, p 251 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-251 2022-12-31T07:26:02Z Abstract Background Neutrophil cytosolic factor 1, p47 phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Selmaj Krysztof W Mycko Marcin P Lell Bertrand Kun Jürgen Vonthein Reinhard Hoffmann Peter Greve Bernhard Berger Klaus Weissert Robert Kremsner Peter G NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Neutrophil cytosolic factor 1, p47 phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the ΔGT/GTGT ratio) may influence the individual capacity to produce ROI. Methods NCF1ΔGT/GTGT ratios were correlated with clinical parameters and ROI production during Plasmodium falciparum malaria and with susceptibility to the autoimmune disease multiple sclerosis (MS). Results Among Gabonese children with severe malaria, ROI production from peripheral blood tended to be higher in individuals with a ΔGT/GTGT ratio ≤ 1:1. ΔGT/GTGT ratios were not associated with susceptibility to MS, but to age-of-onset among MS patients. Conclusion The genomic pattern of NCF1 and its pseudogenes might influence ROI production but only marginally influence susceptibility to and outcome of malaria and MS. |
format |
Article in Journal/Newspaper |
author |
Selmaj Krysztof W Mycko Marcin P Lell Bertrand Kun Jürgen Vonthein Reinhard Hoffmann Peter Greve Bernhard Berger Klaus Weissert Robert Kremsner Peter G |
author_facet |
Selmaj Krysztof W Mycko Marcin P Lell Bertrand Kun Jürgen Vonthein Reinhard Hoffmann Peter Greve Bernhard Berger Klaus Weissert Robert Kremsner Peter G |
author_sort |
Selmaj Krysztof W |
title |
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
title_short |
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
title_full |
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
title_fullStr |
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
title_full_unstemmed |
NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
title_sort |
ncf1 gene and pseudogene pattern: association with parasitic infection and autoimmunity |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-251 https://doaj.org/article/1323eb71bda04730b89e0e58a16fafc9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 251 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/251 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-251 1475-2875 https://doaj.org/article/1323eb71bda04730b89e0e58a16fafc9 |
op_doi |
https://doi.org/10.1186/1475-2875-7-251 |
container_title |
Malaria Journal |
container_volume |
7 |
container_issue |
1 |
_version_ |
1766335902223695872 |