Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study
Objective: To determine the prevalence, level of severity of potential drug–drug interactions (PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital. Methods: A retrospective cross-sectional study was conducted for a period of 3 months from Marc...
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ftdoajarticles:oai:doaj.org/article:1302ce3d84cb45a2a83dc6892b9b6ca6 2023-05-15T15:10:55+02:00 Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study Henok Getachew Mohammed Assen Feser Dula Akshaya Srikanth Bhagavathula 2016-06-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.04.002 https://doaj.org/article/1302ce3d84cb45a2a83dc6892b9b6ca6 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115309783 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.04.002 https://doaj.org/article/1302ce3d84cb45a2a83dc6892b9b6ca6 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 6, Pp 534-538 (2016) Potential drug–drug interaction Pediatric ward Prevalence Ethiopia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.04.002 2022-12-31T02:30:23Z Objective: To determine the prevalence, level of severity of potential drug–drug interactions (PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital. Methods: A retrospective cross-sectional study was conducted for a period of 3 months from March to May 2014 in pediatric wards of Gondar University Hospital. Systematic random sampling technique was used to select charts from all pediatric patients' charts with every 7th interval to get sample size of 384. Univariate and multivariate analysis were performed to compute crude odds ratio and adjusted odds ratio respectively. Statistical significance was set at P value < 0.05. Results: A total of 176 (45.8%) patients had at least one PDDI. A total of 393 PDDIs, which were comprised of 283 types of interacting combinations, were identified. Of the total of 393 PDDIs, most were of moderate severity [201 (51%)] followed by minor [152 (39%)] and major severity [40 (10%)]. The most common interacting pairs of major severity were gentamicin + furosemide (6), cotrimoxazole + methotrexate (4) and phenytoin + artemether (4). The occurrence of PDDIs was significantly associated with age and polypharmacy. Conclusions: The study showed that most of the interactions had moderate severity followed by minor severity. Age and polypharmacy were found to show statistically significant association with the occurrence of PDDIs. Due to sensitive nature of pediatrics population, close monitoring is recommended for the detection and management of PDDIs to prevent its negative consequences. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 6 534 538 |
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topic |
Potential drug–drug interaction Pediatric ward Prevalence Ethiopia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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Potential drug–drug interaction Pediatric ward Prevalence Ethiopia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Henok Getachew Mohammed Assen Feser Dula Akshaya Srikanth Bhagavathula Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study |
topic_facet |
Potential drug–drug interaction Pediatric ward Prevalence Ethiopia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To determine the prevalence, level of severity of potential drug–drug interactions (PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital. Methods: A retrospective cross-sectional study was conducted for a period of 3 months from March to May 2014 in pediatric wards of Gondar University Hospital. Systematic random sampling technique was used to select charts from all pediatric patients' charts with every 7th interval to get sample size of 384. Univariate and multivariate analysis were performed to compute crude odds ratio and adjusted odds ratio respectively. Statistical significance was set at P value < 0.05. Results: A total of 176 (45.8%) patients had at least one PDDI. A total of 393 PDDIs, which were comprised of 283 types of interacting combinations, were identified. Of the total of 393 PDDIs, most were of moderate severity [201 (51%)] followed by minor [152 (39%)] and major severity [40 (10%)]. The most common interacting pairs of major severity were gentamicin + furosemide (6), cotrimoxazole + methotrexate (4) and phenytoin + artemether (4). The occurrence of PDDIs was significantly associated with age and polypharmacy. Conclusions: The study showed that most of the interactions had moderate severity followed by minor severity. Age and polypharmacy were found to show statistically significant association with the occurrence of PDDIs. Due to sensitive nature of pediatrics population, close monitoring is recommended for the detection and management of PDDIs to prevent its negative consequences. |
format |
Article in Journal/Newspaper |
author |
Henok Getachew Mohammed Assen Feser Dula Akshaya Srikanth Bhagavathula |
author_facet |
Henok Getachew Mohammed Assen Feser Dula Akshaya Srikanth Bhagavathula |
author_sort |
Henok Getachew |
title |
Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study |
title_short |
Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study |
title_full |
Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study |
title_fullStr |
Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study |
title_full_unstemmed |
Potential drug–drug interactions in pediatric wards of Gondar University Hospital, Ethiopia: A cross sectional study |
title_sort |
potential drug–drug interactions in pediatric wards of gondar university hospital, ethiopia: a cross sectional study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2016.04.002 https://doaj.org/article/1302ce3d84cb45a2a83dc6892b9b6ca6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 6, Pp 534-538 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115309783 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.04.002 https://doaj.org/article/1302ce3d84cb45a2a83dc6892b9b6ca6 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.04.002 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
6 |
container_start_page |
534 |
op_container_end_page |
538 |
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1766341844787003392 |