Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore.
BACKGROUND: Dengue illness causes 50-100 million infections worldwide and threatens 2.5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines...
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ftdoajarticles:oai:doaj.org/article:12ad08001f2e4429b5b495631a668ac9 2023-05-15T15:15:39+02:00 Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. Luis R Carrasco Linda K Lee Vernon J Lee Eng Eong Ooi Donald S Shepard Tun L Thein Victor Gan Alex R Cook David Lye Lee Ching Ng Yee Sin Leo 2011-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001426 https://doaj.org/article/12ad08001f2e4429b5b495631a668ac9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3243704?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001426 1935-2727 1935-2735 https://doaj.org/article/12ad08001f2e4429b5b495631a668ac9 PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1426 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001426 2022-12-31T03:18:18Z BACKGROUND: Dengue illness causes 50-100 million infections worldwide and threatens 2.5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines in such settings. METHODS AND FINDINGS: We estimate the direct and indirect costs of dengue from hospitalized and ambulatory cases in Singapore. We consider inter alia the impacts of dengue on the economy using the human-capital and the friction cost methods. Disease burden was estimated using disability-adjusted life years (DALYs) and the cost-effectiveness of a potential vaccine program was evaluated. The average economic impact of dengue illness in Singapore from 2000 to 2009 in constant 2010 US$ ranged between $0.85 billion and $1.15 billion, of which control costs constitute 42%-59%. Using empirically derived disability weights, we estimated an annual average disease burden of 9-14 DALYs per 100 000 habitants, making it comparable to diseases such as hepatitis B or syphilis. The proportion of symptomatic dengue cases detected by the national surveillance system was estimated to be low, and to decrease with age. Under population projections by the United Nations, the price per dose threshold for which vaccines stop being more cost-effective than the current vector control program ranged from $50 for mass vaccination requiring 3 doses and only conferring 10 years of immunity to $300 for vaccination requiring 2 doses and conferring lifetime immunity. The thresholds for these vaccine programs to not be cost-effective for Singapore were $100 and $500 per dose respectively. CONCLUSIONS: Dengue illness presents a serious economic and disease burden in Singapore. Dengue vaccines are expected to be cost-effective if reasonably low prices are adopted and will help to reduce the economic and disease burden of dengue in Singapore substantially. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 12 e1426 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Luis R Carrasco Linda K Lee Vernon J Lee Eng Eong Ooi Donald S Shepard Tun L Thein Victor Gan Alex R Cook David Lye Lee Ching Ng Yee Sin Leo Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Dengue illness causes 50-100 million infections worldwide and threatens 2.5 billion people in the tropical and subtropical regions. Little is known about the disease burden and economic impact of dengue in higher resourced countries or the cost-effectiveness of potential dengue vaccines in such settings. METHODS AND FINDINGS: We estimate the direct and indirect costs of dengue from hospitalized and ambulatory cases in Singapore. We consider inter alia the impacts of dengue on the economy using the human-capital and the friction cost methods. Disease burden was estimated using disability-adjusted life years (DALYs) and the cost-effectiveness of a potential vaccine program was evaluated. The average economic impact of dengue illness in Singapore from 2000 to 2009 in constant 2010 US$ ranged between $0.85 billion and $1.15 billion, of which control costs constitute 42%-59%. Using empirically derived disability weights, we estimated an annual average disease burden of 9-14 DALYs per 100 000 habitants, making it comparable to diseases such as hepatitis B or syphilis. The proportion of symptomatic dengue cases detected by the national surveillance system was estimated to be low, and to decrease with age. Under population projections by the United Nations, the price per dose threshold for which vaccines stop being more cost-effective than the current vector control program ranged from $50 for mass vaccination requiring 3 doses and only conferring 10 years of immunity to $300 for vaccination requiring 2 doses and conferring lifetime immunity. The thresholds for these vaccine programs to not be cost-effective for Singapore were $100 and $500 per dose respectively. CONCLUSIONS: Dengue illness presents a serious economic and disease burden in Singapore. Dengue vaccines are expected to be cost-effective if reasonably low prices are adopted and will help to reduce the economic and disease burden of dengue in Singapore substantially. |
format |
Article in Journal/Newspaper |
author |
Luis R Carrasco Linda K Lee Vernon J Lee Eng Eong Ooi Donald S Shepard Tun L Thein Victor Gan Alex R Cook David Lye Lee Ching Ng Yee Sin Leo |
author_facet |
Luis R Carrasco Linda K Lee Vernon J Lee Eng Eong Ooi Donald S Shepard Tun L Thein Victor Gan Alex R Cook David Lye Lee Ching Ng Yee Sin Leo |
author_sort |
Luis R Carrasco |
title |
Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. |
title_short |
Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. |
title_full |
Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. |
title_fullStr |
Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. |
title_full_unstemmed |
Economic impact of dengue illness and the cost-effectiveness of future vaccination programs in Singapore. |
title_sort |
economic impact of dengue illness and the cost-effectiveness of future vaccination programs in singapore. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001426 https://doaj.org/article/12ad08001f2e4429b5b495631a668ac9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1426 (2011) |
op_relation |
http://europepmc.org/articles/PMC3243704?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0001426 1935-2727 1935-2735 https://doaj.org/article/12ad08001f2e4429b5b495631a668ac9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001426 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
5 |
container_issue |
12 |
container_start_page |
e1426 |
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1766346010055933952 |