High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite.
The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is oft...
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ftdoajarticles:oai:doaj.org/article:12a8e16e28484afd90780687cbffde09 2023-05-15T15:04:21+02:00 High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. Pasi K Korhonen Robin B Gasser Guangxu Ma Tao Wang Andreas J Stroehlein Neil D Young Ching-Seng Ang Deepani D Fernando Hieng C Lu Sara Taylor Simone L Reynolds Ehtesham Mofiz Shivashankar H Najaraj Harsha Gowda Anil Madugundu Santosh Renuse Deborah Holt Akhilesh Pandey Anthony T Papenfuss Katja Fischer 2020-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008720 https://doaj.org/article/12a8e16e28484afd90780687cbffde09 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008720 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008720 https://doaj.org/article/12a8e16e28484afd90780687cbffde09 PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008720 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008720 2022-12-31T07:46:37Z The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests. Article in Journal/Newspaper Arctic Mite Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 10 e0008720 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pasi K Korhonen Robin B Gasser Guangxu Ma Tao Wang Andreas J Stroehlein Neil D Young Ching-Seng Ang Deepani D Fernando Hieng C Lu Sara Taylor Simone L Reynolds Ehtesham Mofiz Shivashankar H Najaraj Harsha Gowda Anil Madugundu Santosh Renuse Deborah Holt Akhilesh Pandey Anthony T Papenfuss Katja Fischer High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests. |
format |
Article in Journal/Newspaper |
author |
Pasi K Korhonen Robin B Gasser Guangxu Ma Tao Wang Andreas J Stroehlein Neil D Young Ching-Seng Ang Deepani D Fernando Hieng C Lu Sara Taylor Simone L Reynolds Ehtesham Mofiz Shivashankar H Najaraj Harsha Gowda Anil Madugundu Santosh Renuse Deborah Holt Akhilesh Pandey Anthony T Papenfuss Katja Fischer |
author_facet |
Pasi K Korhonen Robin B Gasser Guangxu Ma Tao Wang Andreas J Stroehlein Neil D Young Ching-Seng Ang Deepani D Fernando Hieng C Lu Sara Taylor Simone L Reynolds Ehtesham Mofiz Shivashankar H Najaraj Harsha Gowda Anil Madugundu Santosh Renuse Deborah Holt Akhilesh Pandey Anthony T Papenfuss Katja Fischer |
author_sort |
Pasi K Korhonen |
title |
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. |
title_short |
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. |
title_full |
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. |
title_fullStr |
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. |
title_full_unstemmed |
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite. |
title_sort |
high-quality nuclear genome for sarcoptes scabiei-a critical resource for a neglected parasite. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008720 https://doaj.org/article/12a8e16e28484afd90780687cbffde09 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Mite |
genre_facet |
Arctic Mite |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008720 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008720 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008720 https://doaj.org/article/12a8e16e28484afd90780687cbffde09 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008720 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
14 |
container_issue |
10 |
container_start_page |
e0008720 |
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1766336144172122112 |