Bacterial lysates: conventional views and a new paradigm
A.L. Zaplatnikov 1 , A.A. Girina 2 , V.I. Svintsitskaya 1 , I.V. Lepiseva 3 , M.V. Leshik 1 1 Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation 2 Khanty-Mansi State Medical Academy, Khanty-Mansiysk, Russian Federation 3 Children’s Republican Hospital, Petrozavo...
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ftdoajarticles:oai:doaj.org/article:12785199a8114327aff3519056dcac92 2024-09-09T19:50:02+00:00 Bacterial lysates: conventional views and a new paradigm A.L. Zaplatnikov A.A. Garina V.I. Svinitskaya Lepiseva I.V M.V. Leshik 2021-09-01T00:00:00Z https://doaj.org/article/12785199a8114327aff3519056dcac92 RU rus LCC «Medicine-Inform» http://wchjournal.com/upload/iblock/aa6/aa6f7e3976b9310b5505c8453a06c32a.pdf https://doaj.org/toc/2618-8430 https://doaj.org/toc/2686-7184 2618-8430 2686-7184 https://doaj.org/article/12785199a8114327aff3519056dcac92 РМЖ. Мать и дитя, Vol 4, Iss 3 (2021) Pediatrics RJ1-570 Gynecology and obstetrics RG1-991 article 2021 ftdoajarticles 2024-08-05T17:49:57Z A.L. Zaplatnikov 1 , A.A. Girina 2 , V.I. Svintsitskaya 1 , I.V. Lepiseva 3 , M.V. Leshik 1 1 Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation 2 Khanty-Mansi State Medical Academy, Khanty-Mansiysk, Russian Federation 3 Children’s Republican Hospital, Petrozavodsk, Russian Federation This paper addresses published data on therapeutic, preventive efficacy, and safety of bacterial lysates (BLs) in pediatric practice. Studies on the mechanisms of action of BLs are discussed. Experimental evidence demonstrates that the preventive effect of BLs is maintained even in the high level of bacterial lysis characterized by the presence of only small peptides or even their fragments without antigenic properties. The authors discuss the potential involvement of BLs in the development of trained immunity, whose effects last less time than a conventional epitope-specific adaptive immune memory. The article provides a pathogenic basis for BL use to prevent and manage recurrent respiratory infections and control respiratory allergic diseases as a part of complex treatment. Our data demonstrate a high efficacy of polyvalent mechanical BL to prevent acute and recurrent respiratory infections in children of organized communities, a reduced rate of bacterial complications, and 20 the rate of antibiotic prescription when using BLs. Good tolerability and the lack of adverse and side effects of BLs are emphasized. Keywords : bacterial lysates, asthma, children, immunity, immune prophylaxis, polyvalent mechanical bacterial lysate, respiratory infections, recurrent respiratory infections, trained immunity. For citation: Zaplatnikov A.L., Girina A.A., Svintsitskaya V.I. et al. Bacterial lysates: conventional views and a new paradigm. Russian Journal of Woman and Child Health. 2021;4(3):284–291 (in Russ.). DOI:10.32364/2618-8430-2021-4-3-284-291. Article in Journal/Newspaper khanty khanty-mansi Mansi Directory of Open Access Journals: DOAJ Articles |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
Russian |
topic |
Pediatrics RJ1-570 Gynecology and obstetrics RG1-991 |
spellingShingle |
Pediatrics RJ1-570 Gynecology and obstetrics RG1-991 A.L. Zaplatnikov A.A. Garina V.I. Svinitskaya Lepiseva I.V M.V. Leshik Bacterial lysates: conventional views and a new paradigm |
topic_facet |
Pediatrics RJ1-570 Gynecology and obstetrics RG1-991 |
description |
A.L. Zaplatnikov 1 , A.A. Girina 2 , V.I. Svintsitskaya 1 , I.V. Lepiseva 3 , M.V. Leshik 1 1 Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation 2 Khanty-Mansi State Medical Academy, Khanty-Mansiysk, Russian Federation 3 Children’s Republican Hospital, Petrozavodsk, Russian Federation This paper addresses published data on therapeutic, preventive efficacy, and safety of bacterial lysates (BLs) in pediatric practice. Studies on the mechanisms of action of BLs are discussed. Experimental evidence demonstrates that the preventive effect of BLs is maintained even in the high level of bacterial lysis characterized by the presence of only small peptides or even their fragments without antigenic properties. The authors discuss the potential involvement of BLs in the development of trained immunity, whose effects last less time than a conventional epitope-specific adaptive immune memory. The article provides a pathogenic basis for BL use to prevent and manage recurrent respiratory infections and control respiratory allergic diseases as a part of complex treatment. Our data demonstrate a high efficacy of polyvalent mechanical BL to prevent acute and recurrent respiratory infections in children of organized communities, a reduced rate of bacterial complications, and 20 the rate of antibiotic prescription when using BLs. Good tolerability and the lack of adverse and side effects of BLs are emphasized. Keywords : bacterial lysates, asthma, children, immunity, immune prophylaxis, polyvalent mechanical bacterial lysate, respiratory infections, recurrent respiratory infections, trained immunity. For citation: Zaplatnikov A.L., Girina A.A., Svintsitskaya V.I. et al. Bacterial lysates: conventional views and a new paradigm. Russian Journal of Woman and Child Health. 2021;4(3):284–291 (in Russ.). DOI:10.32364/2618-8430-2021-4-3-284-291. |
format |
Article in Journal/Newspaper |
author |
A.L. Zaplatnikov A.A. Garina V.I. Svinitskaya Lepiseva I.V M.V. Leshik |
author_facet |
A.L. Zaplatnikov A.A. Garina V.I. Svinitskaya Lepiseva I.V M.V. Leshik |
author_sort |
A.L. Zaplatnikov |
title |
Bacterial lysates: conventional views and a new paradigm |
title_short |
Bacterial lysates: conventional views and a new paradigm |
title_full |
Bacterial lysates: conventional views and a new paradigm |
title_fullStr |
Bacterial lysates: conventional views and a new paradigm |
title_full_unstemmed |
Bacterial lysates: conventional views and a new paradigm |
title_sort |
bacterial lysates: conventional views and a new paradigm |
publisher |
LCC «Medicine-Inform» |
publishDate |
2021 |
url |
https://doaj.org/article/12785199a8114327aff3519056dcac92 |
genre |
khanty khanty-mansi Mansi |
genre_facet |
khanty khanty-mansi Mansi |
op_source |
РМЖ. Мать и дитя, Vol 4, Iss 3 (2021) |
op_relation |
http://wchjournal.com/upload/iblock/aa6/aa6f7e3976b9310b5505c8453a06c32a.pdf https://doaj.org/toc/2618-8430 https://doaj.org/toc/2686-7184 2618-8430 2686-7184 https://doaj.org/article/12785199a8114327aff3519056dcac92 |
_version_ |
1809919399097794560 |