Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach.
Rickettsiosis is a re-emergent infectious disease without epidemiological surveillance in Colombia. This disease is generally undiagnosed and several deadly outbreaks have been reported in the country in the last decade. The aim of this study is to analyze the eco-epidemiological aspects of ricketts...
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ftdoajarticles:oai:doaj.org/article:11da4a5229ac436faacd3be78b8e749a 2023-05-15T15:14:19+02:00 Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. Juan C Quintero V Luis E Paternina T Alexander Uribe Y Carlos Muskus Marylin Hidalgo Juliana Gil Astrid V Cienfuegos G Lisardo Osorio Q Carlos Rojas A 2017-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005892 https://doaj.org/article/11da4a5229ac436faacd3be78b8e749a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5619838?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005892 https://doaj.org/article/11da4a5229ac436faacd3be78b8e749a PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005892 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005892 2022-12-31T05:33:52Z Rickettsiosis is a re-emergent infectious disease without epidemiological surveillance in Colombia. This disease is generally undiagnosed and several deadly outbreaks have been reported in the country in the last decade. The aim of this study is to analyze the eco-epidemiological aspects of rickettsial seropositivity in rural areas of Colombia where outbreaks of the disease were previously reported. A cross-sectional study, which included 597 people living in 246 households from nine hamlets in two municipalities of Colombia, was conducted from November 2015 to January 2016. The survey was conducted to collect sociodemographic and household characteristics (exposure) data. Blood samples were collected to determine the rickettsial seropositivity in humans, horses and dogs (IFA, cut-off = 1/128). In addition, infections by rickettsiae were detected in ticks from humans and animals by real-time PCR targeting gltA and ompA genes. Data was analyzed by weighted multilevel clog-log regression model using three levels (person, household and hamlets) and rickettsial seropositivity in humans was the main outcome. Overall prevalence of rickettsial seropositivity in humans was 25.62% (95%CI 22.11-29.12). Age in years (PR = 1.01 95%CI 1.01-1.02) and male sex (PR = 1.65 95%CI 1.43-1.90) were risk markers for rickettsial seropositivity. Working outdoors (PR = 1.20 95%CI 1.02-1.41), deforestation and forest fragmentation for agriculture use (PR = 1.75 95%CI 1.51-2.02), opossum in peridomiciliary area (PR = 1.56 95%CI 1.37-1.79) and a high proportion of seropositive domestic animals in the home (PR20-40% vs <20% = 2.28 95%CI 1.59-3.23 and PR>40% vs <20% = 3.14 95%CI 2.43-4.04) were associated with rickettsial seropositivity in humans. This study showed the presence of Rickettsia antibodies in human populations and domestic animals. In addition, different species of rickettsiae were detected in ticks collected from humans and animals. Our results highlighted the role of domestic animals as sentinels of rickettsial ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 9 e0005892 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Juan C Quintero V Luis E Paternina T Alexander Uribe Y Carlos Muskus Marylin Hidalgo Juliana Gil Astrid V Cienfuegos G Lisardo Osorio Q Carlos Rojas A Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Rickettsiosis is a re-emergent infectious disease without epidemiological surveillance in Colombia. This disease is generally undiagnosed and several deadly outbreaks have been reported in the country in the last decade. The aim of this study is to analyze the eco-epidemiological aspects of rickettsial seropositivity in rural areas of Colombia where outbreaks of the disease were previously reported. A cross-sectional study, which included 597 people living in 246 households from nine hamlets in two municipalities of Colombia, was conducted from November 2015 to January 2016. The survey was conducted to collect sociodemographic and household characteristics (exposure) data. Blood samples were collected to determine the rickettsial seropositivity in humans, horses and dogs (IFA, cut-off = 1/128). In addition, infections by rickettsiae were detected in ticks from humans and animals by real-time PCR targeting gltA and ompA genes. Data was analyzed by weighted multilevel clog-log regression model using three levels (person, household and hamlets) and rickettsial seropositivity in humans was the main outcome. Overall prevalence of rickettsial seropositivity in humans was 25.62% (95%CI 22.11-29.12). Age in years (PR = 1.01 95%CI 1.01-1.02) and male sex (PR = 1.65 95%CI 1.43-1.90) were risk markers for rickettsial seropositivity. Working outdoors (PR = 1.20 95%CI 1.02-1.41), deforestation and forest fragmentation for agriculture use (PR = 1.75 95%CI 1.51-2.02), opossum in peridomiciliary area (PR = 1.56 95%CI 1.37-1.79) and a high proportion of seropositive domestic animals in the home (PR20-40% vs <20% = 2.28 95%CI 1.59-3.23 and PR>40% vs <20% = 3.14 95%CI 2.43-4.04) were associated with rickettsial seropositivity in humans. This study showed the presence of Rickettsia antibodies in human populations and domestic animals. In addition, different species of rickettsiae were detected in ticks collected from humans and animals. Our results highlighted the role of domestic animals as sentinels of rickettsial ... |
format |
Article in Journal/Newspaper |
author |
Juan C Quintero V Luis E Paternina T Alexander Uribe Y Carlos Muskus Marylin Hidalgo Juliana Gil Astrid V Cienfuegos G Lisardo Osorio Q Carlos Rojas A |
author_facet |
Juan C Quintero V Luis E Paternina T Alexander Uribe Y Carlos Muskus Marylin Hidalgo Juliana Gil Astrid V Cienfuegos G Lisardo Osorio Q Carlos Rojas A |
author_sort |
Juan C Quintero V |
title |
Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. |
title_short |
Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. |
title_full |
Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. |
title_fullStr |
Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. |
title_full_unstemmed |
Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. |
title_sort |
eco-epidemiological analysis of rickettsial seropositivity in rural areas of colombia: a multilevel approach. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005892 https://doaj.org/article/11da4a5229ac436faacd3be78b8e749a |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005892 (2017) |
op_relation |
http://europepmc.org/articles/PMC5619838?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005892 https://doaj.org/article/11da4a5229ac436faacd3be78b8e749a |
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https://doi.org/10.1371/journal.pntd.0005892 |
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PLOS Neglected Tropical Diseases |
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11 |
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e0005892 |
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