Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age
Vaccination of infants with conjugated Haemophilus influenzae type b (Hib) vaccines has been proven to reduce Hib meningitis by 95% and pneumoniae by 20%. The routine use of Hib vaccine is facilitated by the introduction of combination vaccines into the EPI (Expanded Plan of Immunization). The objec...
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ftdoajarticles:oai:doaj.org/article:11cb376cb2704219829d1b7ef2ac773b 2023-05-15T15:07:54+02:00 Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age SueAnn Costa Clemens Tania Azevedo Akira Homma 2003-06-01T00:00:00Z https://doaj.org/article/11cb376cb2704219829d1b7ef2ac773b EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300002&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/11cb376cb2704219829d1b7ef2ac773b Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 3, Pp 321-330 (2003) Combination vaccines DTPw/Hib Brazilian vaccines technology transfer Arctic medicine. Tropical medicine RC955-962 article 2003 ftdoajarticles 2022-12-31T03:20:23Z Vaccination of infants with conjugated Haemophilus influenzae type b (Hib) vaccines has been proven to reduce Hib meningitis by 95% and pneumoniae by 20%. The routine use of Hib vaccine is facilitated by the introduction of combination vaccines into the EPI (Expanded Plan of Immunization). The objective of this study was to compare the immunogenicity and reactogenicity of an extemporaneously mixed DTPw/Hib (diphtheria-tetanus-whole cell pertussis) combination, using the technology of two Brazilian manufacturers, against a licensed DTPw/Hib European combination in 108 infants vaccinated at 2, 4 and 6 months according to the local national schedule. The Brazilian combination was highly immunogenic with Hib seroprotection rates (anti-PRP > 0.15 mg /ml of 98% after 2 doses and 100% after 3). Also for tetanus and pertussis the new Brazilian combination was as immunogenic as the European counterpart, except the diphtheria seroprotection rates and titers were lower. There was also no clinically relevant difference in reactogenicity. If these feasibility results are confirmed, the Brazilian DTPw/Hib combination should help to boost the uptake of Hib vaccination in Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Combination vaccines DTPw/Hib Brazilian vaccines technology transfer Arctic medicine. Tropical medicine RC955-962 |
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Combination vaccines DTPw/Hib Brazilian vaccines technology transfer Arctic medicine. Tropical medicine RC955-962 SueAnn Costa Clemens Tania Azevedo Akira Homma Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
topic_facet |
Combination vaccines DTPw/Hib Brazilian vaccines technology transfer Arctic medicine. Tropical medicine RC955-962 |
description |
Vaccination of infants with conjugated Haemophilus influenzae type b (Hib) vaccines has been proven to reduce Hib meningitis by 95% and pneumoniae by 20%. The routine use of Hib vaccine is facilitated by the introduction of combination vaccines into the EPI (Expanded Plan of Immunization). The objective of this study was to compare the immunogenicity and reactogenicity of an extemporaneously mixed DTPw/Hib (diphtheria-tetanus-whole cell pertussis) combination, using the technology of two Brazilian manufacturers, against a licensed DTPw/Hib European combination in 108 infants vaccinated at 2, 4 and 6 months according to the local national schedule. The Brazilian combination was highly immunogenic with Hib seroprotection rates (anti-PRP > 0.15 mg /ml of 98% after 2 doses and 100% after 3). Also for tetanus and pertussis the new Brazilian combination was as immunogenic as the European counterpart, except the diphtheria seroprotection rates and titers were lower. There was also no clinically relevant difference in reactogenicity. If these feasibility results are confirmed, the Brazilian DTPw/Hib combination should help to boost the uptake of Hib vaccination in Brazil. |
format |
Article in Journal/Newspaper |
author |
SueAnn Costa Clemens Tania Azevedo Akira Homma |
author_facet |
SueAnn Costa Clemens Tania Azevedo Akira Homma |
author_sort |
SueAnn Costa Clemens |
title |
Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
title_short |
Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
title_full |
Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
title_fullStr |
Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
title_full_unstemmed |
Feasibility study of the immunogenicity and safety of a novel DTPw/Hib (PRP-T) Brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
title_sort |
feasibility study of the immunogenicity and safety of a novel dtpw/hib (prp-t) brazilian combination compared to a licensed vaccine in healthy children at 2, 4, and 6 months of age |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2003 |
url |
https://doaj.org/article/11cb376cb2704219829d1b7ef2ac773b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 3, Pp 321-330 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000300002&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/11cb376cb2704219829d1b7ef2ac773b |
_version_ |
1766339334269566976 |