Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni
Introduction This study aimed to evaluate whether a low platelet count is a good surrogate marker of hepatosplenic schistosomiasis (HSS) in a rural area of Brazil. A small district in southeastern Brazil, with a population of 1,543 individuals and a 23% prevalence of schistosomiasis, was selected fo...
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ftdoajarticles:oai:doaj.org/article:118659899256436488dbfa4f8901c20b 2023-05-15T15:09:36+02:00 Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni Sandra Costa Drummond Pedro Nunes Pereira Alba Otoni Bruna Assis Chaves Carlos Maurício Antunes José Roberto Lambertucci 2014-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0020-2014 https://doaj.org/article/118659899256436488dbfa4f8901c20b EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200218&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0020-2014 https://doaj.org/article/118659899256436488dbfa4f8901c20b Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 2, Pp 218-222 (2014) Thrombocytopenia Platelets Hepatosplenic schistosomiasis Pseudo-thrombocytopenia Schistosomiasis mansoni Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles https://doi.org/10.1590/0037-8682-0020-2014 2022-12-31T02:57:40Z Introduction This study aimed to evaluate whether a low platelet count is a good surrogate marker of hepatosplenic schistosomiasis (HSS) in a rural area of Brazil. A small district in southeastern Brazil, with a population of 1,543 individuals and a 23% prevalence of schistosomiasis, was selected for this investigation. Methods In July 2012, 384 volunteers were subjected to clinical, ultrasonography (US), and laboratory examinations, including stool sample analysis. The HSS patients were classified into four groups: Group 1 consisted of patients with a spleen >13cm and liver fibrosis; Group 2 consisted of patients with a palpable spleen and spleen>13cm measured by US; Group 3 consisted of patients with a spleen >13cm measured by US; and Group 4 consisted of patients with a palpable spleen. Results Eight patients were in Group 1 (2.1%), twenty-one were in Group 2 (5.5%), eight were in Group 3 (2.1%), and eighteen were in Group 4 (4.7%). A significant difference in the mean platelet counts was observed between the patients with and without HSS (p<0.01). Based on the receiver operating characteristic (ROC) curve (platelet count <143,000/mm3), the sensitivity was greater than 92% in all groups, and the specificity varied from 44.4% to 75%. Conclusions We concluded that in endemic areas, thrombocytopenia demonstrates good sensitivity for detecting HSS and may be used as a screening tool to identify patients with HSS. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 47 2 218 222 |
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English |
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Thrombocytopenia Platelets Hepatosplenic schistosomiasis Pseudo-thrombocytopenia Schistosomiasis mansoni Arctic medicine. Tropical medicine RC955-962 |
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Thrombocytopenia Platelets Hepatosplenic schistosomiasis Pseudo-thrombocytopenia Schistosomiasis mansoni Arctic medicine. Tropical medicine RC955-962 Sandra Costa Drummond Pedro Nunes Pereira Alba Otoni Bruna Assis Chaves Carlos Maurício Antunes José Roberto Lambertucci Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni |
topic_facet |
Thrombocytopenia Platelets Hepatosplenic schistosomiasis Pseudo-thrombocytopenia Schistosomiasis mansoni Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction This study aimed to evaluate whether a low platelet count is a good surrogate marker of hepatosplenic schistosomiasis (HSS) in a rural area of Brazil. A small district in southeastern Brazil, with a population of 1,543 individuals and a 23% prevalence of schistosomiasis, was selected for this investigation. Methods In July 2012, 384 volunteers were subjected to clinical, ultrasonography (US), and laboratory examinations, including stool sample analysis. The HSS patients were classified into four groups: Group 1 consisted of patients with a spleen >13cm and liver fibrosis; Group 2 consisted of patients with a palpable spleen and spleen>13cm measured by US; Group 3 consisted of patients with a spleen >13cm measured by US; and Group 4 consisted of patients with a palpable spleen. Results Eight patients were in Group 1 (2.1%), twenty-one were in Group 2 (5.5%), eight were in Group 3 (2.1%), and eighteen were in Group 4 (4.7%). A significant difference in the mean platelet counts was observed between the patients with and without HSS (p<0.01). Based on the receiver operating characteristic (ROC) curve (platelet count <143,000/mm3), the sensitivity was greater than 92% in all groups, and the specificity varied from 44.4% to 75%. Conclusions We concluded that in endemic areas, thrombocytopenia demonstrates good sensitivity for detecting HSS and may be used as a screening tool to identify patients with HSS. |
format |
Article in Journal/Newspaper |
author |
Sandra Costa Drummond Pedro Nunes Pereira Alba Otoni Bruna Assis Chaves Carlos Maurício Antunes José Roberto Lambertucci |
author_facet |
Sandra Costa Drummond Pedro Nunes Pereira Alba Otoni Bruna Assis Chaves Carlos Maurício Antunes José Roberto Lambertucci |
author_sort |
Sandra Costa Drummond |
title |
Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni |
title_short |
Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni |
title_full |
Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni |
title_fullStr |
Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni |
title_full_unstemmed |
Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni |
title_sort |
thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for schistosomiasis mansoni |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2014 |
url |
https://doi.org/10.1590/0037-8682-0020-2014 https://doaj.org/article/118659899256436488dbfa4f8901c20b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 47, Iss 2, Pp 218-222 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822014000200218&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0020-2014 https://doaj.org/article/118659899256436488dbfa4f8901c20b |
op_doi |
https://doi.org/10.1590/0037-8682-0020-2014 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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47 |
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218 |
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