Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
Abstract Background The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast As...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-021-03987-6 https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44 |
id |
ftdoajarticles:oai:doaj.org/article:118424902a0b4d6d95dcc1d5bc867d44 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:118424902a0b4d6d95dcc1d5bc867d44 2023-05-15T15:16:43+02:00 Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola 2021-12-01T00:00:00Z https://doi.org/10.1186/s12936-021-03987-6 https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44 EN eng BMC https://doi.org/10.1186/s12936-021-03987-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03987-6 1475-2875 https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44 Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021) Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03987-6 2022-12-31T05:04:22Z Abstract Background The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards treatment failure. Monitoring the prevalence of mutations associated with artemisinin resistance in African populations is necessary to stop resistance in its tracks. Mutations in Plasmodium falciparum genes pfk13, pfcoronin and pfatpase6 have been linked with ART partial resistance. Methods Findings from published research articles on the prevalence of pfk13, pfcoronin and pfatpase6 polymorphisms in Africa were collated. PubMed, Embase and Google Scholar were searched for relevant articles reporting polymorphisms in these genes across Africa from 2014 to August 2021, for pfk13 and pfcoronin. For pfatpase6, relevant articles between 2003 and August 2021 were retrieved. Results Eighty-seven studies passed the inclusion criteria for this analysis and reported 742 single nucleotide polymorphisms in 37,864 P. falciparum isolates from 29 African countries. Five validated-pfk13 partial resistance markers were identified in Africa: R561H in Rwanda and Tanzania, M476I in Tanzania, F446I in Mali, C580Y in Ghana, and P553L in an Angolan isolate. In Tanzania, three (L263E, E431K, S769N) of the four mutations (L263E, E431K, A623E, S769N) in pfatpase6 gene associated with high in vitro IC50 were reported. pfcoronin polymorphisms were reported in Senegal, Gabon, Ghana, Kenya, and Congo, with P76S being the most prevalent mutation. Conclusions This meta-analysis provides an overview of the prevalence and widespread distribution of pfk13, pfcoronin and pfatpase6 mutations in Africa. Understanding the phenotypic consequences of these mutations can provide information on the efficacy status of artemisinin-based treatment ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum |
topic_facet |
Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards treatment failure. Monitoring the prevalence of mutations associated with artemisinin resistance in African populations is necessary to stop resistance in its tracks. Mutations in Plasmodium falciparum genes pfk13, pfcoronin and pfatpase6 have been linked with ART partial resistance. Methods Findings from published research articles on the prevalence of pfk13, pfcoronin and pfatpase6 polymorphisms in Africa were collated. PubMed, Embase and Google Scholar were searched for relevant articles reporting polymorphisms in these genes across Africa from 2014 to August 2021, for pfk13 and pfcoronin. For pfatpase6, relevant articles between 2003 and August 2021 were retrieved. Results Eighty-seven studies passed the inclusion criteria for this analysis and reported 742 single nucleotide polymorphisms in 37,864 P. falciparum isolates from 29 African countries. Five validated-pfk13 partial resistance markers were identified in Africa: R561H in Rwanda and Tanzania, M476I in Tanzania, F446I in Mali, C580Y in Ghana, and P553L in an Angolan isolate. In Tanzania, three (L263E, E431K, S769N) of the four mutations (L263E, E431K, A623E, S769N) in pfatpase6 gene associated with high in vitro IC50 were reported. pfcoronin polymorphisms were reported in Senegal, Gabon, Ghana, Kenya, and Congo, with P76S being the most prevalent mutation. Conclusions This meta-analysis provides an overview of the prevalence and widespread distribution of pfk13, pfcoronin and pfatpase6 mutations in Africa. Understanding the phenotypic consequences of these mutations can provide information on the efficacy status of artemisinin-based treatment ... |
format |
Article in Journal/Newspaper |
author |
Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola |
author_facet |
Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola |
author_sort |
Afolabi Owoloye |
title |
Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum |
title_short |
Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum |
title_full |
Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum |
title_fullStr |
Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum |
title_full_unstemmed |
Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum |
title_sort |
prevalence of potential mediators of artemisinin resistance in african isolates of plasmodium falciparum |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03987-6 https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-12 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03987-6 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03987-6 1475-2875 https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44 |
op_doi |
https://doi.org/10.1186/s12936-021-03987-6 |
container_title |
Malaria Journal |
container_volume |
20 |
container_issue |
1 |
_version_ |
1766347010006319104 |