Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data
Abstract The RTS,S/AS candidate malaria vaccine has demonstrated efficacy against a variety of endpoints in Phase IIa and Phase IIb trials over more than a decade. A multi-country phase III trial of RTS,S/AS01 is now underway with submission as early as 2012, if vaccine safety and efficacy are confi...
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ftdoajarticles:oai:doaj.org/article:1180abdeefec4396abbfc326e1497c08 2023-05-15T15:01:31+02:00 Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data Moorthy Vasee S Ballou W Ripley 2009-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-312 https://doaj.org/article/1180abdeefec4396abbfc326e1497c08 EN eng BMC http://www.malariajournal.com/content/8/1/312 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-312 1475-2875 https://doaj.org/article/1180abdeefec4396abbfc326e1497c08 Malaria Journal, Vol 8, Iss 1, p 312 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-312 2022-12-31T08:49:35Z Abstract The RTS,S/AS candidate malaria vaccine has demonstrated efficacy against a variety of endpoints in Phase IIa and Phase IIb trials over more than a decade. A multi-country phase III trial of RTS,S/AS01 is now underway with submission as early as 2012, if vaccine safety and efficacy are confirmed. The immunologic basis for how the vaccine protects against both infection and disease remains uncertain. It is, therefore, timely to review the information currently available about the vaccine with regard to how it impacts the human- Plasmodium falciparum host-pathogen relationship. In this article, what is known about mechanisms involved in partial protection against malaria induced by RTS,S is reviewed. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Moorthy Vasee S Ballou W Ripley Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract The RTS,S/AS candidate malaria vaccine has demonstrated efficacy against a variety of endpoints in Phase IIa and Phase IIb trials over more than a decade. A multi-country phase III trial of RTS,S/AS01 is now underway with submission as early as 2012, if vaccine safety and efficacy are confirmed. The immunologic basis for how the vaccine protects against both infection and disease remains uncertain. It is, therefore, timely to review the information currently available about the vaccine with regard to how it impacts the human- Plasmodium falciparum host-pathogen relationship. In this article, what is known about mechanisms involved in partial protection against malaria induced by RTS,S is reviewed. |
format |
Article in Journal/Newspaper |
author |
Moorthy Vasee S Ballou W Ripley |
author_facet |
Moorthy Vasee S Ballou W Ripley |
author_sort |
Moorthy Vasee S |
title |
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data |
title_short |
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data |
title_full |
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data |
title_fullStr |
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data |
title_full_unstemmed |
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data |
title_sort |
immunological mechanisms underlying protection mediated by rts,s: a review of the available data |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-312 https://doaj.org/article/1180abdeefec4396abbfc326e1497c08 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 312 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/312 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-312 1475-2875 https://doaj.org/article/1180abdeefec4396abbfc326e1497c08 |
op_doi |
https://doi.org/10.1186/1475-2875-8-312 |
container_title |
Malaria Journal |
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8 |
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1 |
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1766333539997974528 |