A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya.
Introduction Estimates suggest that one-third of snakebite cases in sub-Saharan Africa affect children. Despite children being at a greater risk of disability and death, there are limited published data. This study has determined the: population-incidence and mortality rate of hospital-attended paed...
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ftdoajarticles:oai:doaj.org/article:113ed56d6e4b4052a92c984f1125afe0 2024-10-06T13:46:59+00:00 A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. Michael Abouyannis Mwanamvua Boga David Amadi Nelson Ouma Amek Nyaguara Neema Mturi James A Berkley Ifedayo M Adetifa Nicholas R Casewell David G Lalloo Mainga Hamaluba 2023-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010987 https://doaj.org/article/113ed56d6e4b4052a92c984f1125afe0 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010987&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0010987 https://doaj.org/article/113ed56d6e4b4052a92c984f1125afe0 PLoS Neglected Tropical Diseases, Vol 17, Iss 7, p e0010987 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010987 2024-09-25T15:39:10Z Introduction Estimates suggest that one-third of snakebite cases in sub-Saharan Africa affect children. Despite children being at a greater risk of disability and death, there are limited published data. This study has determined the: population-incidence and mortality rate of hospital-attended paediatric snakebite; clinical syndromes of snakebite envenoming; and predictors of severe local tissue damage. Methods All children presenting to Kilifi County Hospital, Kenya with snakebite were identified through the Kilifi Health and Demographic Surveillance System (KHDSS). Cases were prospectively registered, admitted for at least 24-hours, and managed on a paediatric high dependency unit (HDU). Households within the KHDSS study area have been included in 4-monthly surveillance and verbal autopsy, enabling calculation of population-incidence and mortality. Predictors of severe local tissue damage were identified using a multivariate logistic regression analysis. Results Between 2003 and 2021, there were 19,606 admissions to the paediatric HDU, of which 584 were due to snakebite. Amongst young children (≤5-years age) the population-incidence of hospital-attended snakebite was 11.3/100,000 person-years; for children aged 6-12 years this was 29.1/100,000 person-years. Incidence remained consistent over the study period despite the population size increasing (98,967 person-years in 2006; and 153,453 person-years in 2021). Most cases had local envenoming alone, but there were five snakebite associated deaths. Low haemoglobin; raised white blood cell count; low serum sodium; high systolic blood pressure; and an upper limb bite-site were independently associated with the development of severe local tissue damage. Conclusion There is a substantial burden of disease due to paediatric snakebite, and the annual number of cases has increased in-line with population growth. The mortality rate was low, which may reflect the species causing snakebite in this region. The identification of independent predictors of severe local ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 7 e0010987 |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Michael Abouyannis Mwanamvua Boga David Amadi Nelson Ouma Amek Nyaguara Neema Mturi James A Berkley Ifedayo M Adetifa Nicholas R Casewell David G Lalloo Mainga Hamaluba A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Introduction Estimates suggest that one-third of snakebite cases in sub-Saharan Africa affect children. Despite children being at a greater risk of disability and death, there are limited published data. This study has determined the: population-incidence and mortality rate of hospital-attended paediatric snakebite; clinical syndromes of snakebite envenoming; and predictors of severe local tissue damage. Methods All children presenting to Kilifi County Hospital, Kenya with snakebite were identified through the Kilifi Health and Demographic Surveillance System (KHDSS). Cases were prospectively registered, admitted for at least 24-hours, and managed on a paediatric high dependency unit (HDU). Households within the KHDSS study area have been included in 4-monthly surveillance and verbal autopsy, enabling calculation of population-incidence and mortality. Predictors of severe local tissue damage were identified using a multivariate logistic regression analysis. Results Between 2003 and 2021, there were 19,606 admissions to the paediatric HDU, of which 584 were due to snakebite. Amongst young children (≤5-years age) the population-incidence of hospital-attended snakebite was 11.3/100,000 person-years; for children aged 6-12 years this was 29.1/100,000 person-years. Incidence remained consistent over the study period despite the population size increasing (98,967 person-years in 2006; and 153,453 person-years in 2021). Most cases had local envenoming alone, but there were five snakebite associated deaths. Low haemoglobin; raised white blood cell count; low serum sodium; high systolic blood pressure; and an upper limb bite-site were independently associated with the development of severe local tissue damage. Conclusion There is a substantial burden of disease due to paediatric snakebite, and the annual number of cases has increased in-line with population growth. The mortality rate was low, which may reflect the species causing snakebite in this region. The identification of independent predictors of severe local ... |
format |
Article in Journal/Newspaper |
author |
Michael Abouyannis Mwanamvua Boga David Amadi Nelson Ouma Amek Nyaguara Neema Mturi James A Berkley Ifedayo M Adetifa Nicholas R Casewell David G Lalloo Mainga Hamaluba |
author_facet |
Michael Abouyannis Mwanamvua Boga David Amadi Nelson Ouma Amek Nyaguara Neema Mturi James A Berkley Ifedayo M Adetifa Nicholas R Casewell David G Lalloo Mainga Hamaluba |
author_sort |
Michael Abouyannis |
title |
A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. |
title_short |
A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. |
title_full |
A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. |
title_fullStr |
A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. |
title_full_unstemmed |
A long-term observational study of paediatric snakebite in Kilifi County, south-east Kenya. |
title_sort |
long-term observational study of paediatric snakebite in kilifi county, south-east kenya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0010987 https://doaj.org/article/113ed56d6e4b4052a92c984f1125afe0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 7, p e0010987 (2023) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0010987&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 doi:10.1371/journal.pntd.0010987 https://doaj.org/article/113ed56d6e4b4052a92c984f1125afe0 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010987 |
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PLOS Neglected Tropical Diseases |
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17 |
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7 |
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e0010987 |
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