Glucantime resistant Leishmania promastigotes are sensitive to pentostam

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Elizabeth Spangler Andrade Moreira, Juliana Becattini Guerra, Maria de Lourdes Petrillo-Peixoto
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1992
• Subjects: Leishmania; compostos antimoniais pentavalentes; Inibição de crescimento; Infecção experimental; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821992000400006; https://doaj.org/article/112de21aed0841f9a23f9851ad3a9530

Growth inhibition in vitro tests were used to study the susceptibility to pentostam of different Leishmania strains involved in cutaneous and mucocutaneos leishmaniasis - one glucantime sensitive strain, three naturally glucantime resistant strains and one glucantime resistant line developed by in vitro drug exposure. Contrasting with the high degree , of glucantime resistance, all strains were sensitive to pentostam. These differences suggest that there is some relationship between chemical structure and in vitro activity for these antimonial compounds. These data justify a clinical re-evaluation to compare therapeutic efficacy of glucantime and pentostam in the treatment of leishmaniasis.