Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus)
Abstract A 14‐year‐old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis...
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ftdoajarticles:oai:doaj.org/article:10fa530a239246efa64ab0254ae67443 2023-10-29T02:35:31+01:00 Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) Myeon‐Sik Yang Hyejin Yun Ki Chang Lee Chae Woong Lim Bumseok Kim 2022-11-01T00:00:00Z https://doi.org/10.1002/vms3.909 https://doaj.org/article/10fa530a239246efa64ab0254ae67443 EN eng Wiley https://doi.org/10.1002/vms3.909 https://doaj.org/toc/2053-1095 2053-1095 doi:10.1002/vms3.909 https://doaj.org/article/10fa530a239246efa64ab0254ae67443 Veterinary Medicine and Science, Vol 8, Iss 6, Pp 2678-2682 (2022) grey wolf mucoepidermoid carcinoma zoo animal Veterinary medicine SF600-1100 article 2022 ftdoajarticles https://doi.org/10.1002/vms3.909 2023-10-01T00:34:27Z Abstract A 14‐year‐old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate. Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS‐D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha‐SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high‐grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Veterinary Medicine and Science 8 6 2678 2682 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
grey wolf mucoepidermoid carcinoma zoo animal Veterinary medicine SF600-1100 |
spellingShingle |
grey wolf mucoepidermoid carcinoma zoo animal Veterinary medicine SF600-1100 Myeon‐Sik Yang Hyejin Yun Ki Chang Lee Chae Woong Lim Bumseok Kim Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
topic_facet |
grey wolf mucoepidermoid carcinoma zoo animal Veterinary medicine SF600-1100 |
description |
Abstract A 14‐year‐old male grey wolf (Canis lupus) with a history of severe facial swelling was submitted for necropsy. Clinical and radiological examination demonstrated an expansile neoplastic mass in the nasal and frontal sinuses. On necropsy, an amorphous neoplastic mass and extensive necrosis were observed in the nasal turbinate. Microscopic examination revealed a tumour principally composed of obvious clear tumour cells characterised by small hyperchromatic nuclei and abundant clear cytoplasm. These clear cells were positive for mucin with PAS, PAS‐D reaction, and alcian blue (pH 2.5) staining, but negative for PTAH staining. Immunohistochemically, some of tumour cells were strongly positive for mesenchymal cells (vimentin), whereas they were negative for myoepithelial antigen (alpha‐SMA) and cytokeratin. Based on the histopathological and immunohistochemical features, the present case was diagnosed as high‐grade clear cell variant mucoepidermoid carcinoma (MEC). This is the first description of clear cell variant MEC in a wolf. |
format |
Article in Journal/Newspaper |
author |
Myeon‐Sik Yang Hyejin Yun Ki Chang Lee Chae Woong Lim Bumseok Kim |
author_facet |
Myeon‐Sik Yang Hyejin Yun Ki Chang Lee Chae Woong Lim Bumseok Kim |
author_sort |
Myeon‐Sik Yang |
title |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_short |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_full |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_fullStr |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_full_unstemmed |
Clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (Canis lupus) |
title_sort |
clear cell variant mucoepidermoid carcinoma of salivary gland in a grey wolf (canis lupus) |
publisher |
Wiley |
publishDate |
2022 |
url |
https://doi.org/10.1002/vms3.909 https://doaj.org/article/10fa530a239246efa64ab0254ae67443 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Veterinary Medicine and Science, Vol 8, Iss 6, Pp 2678-2682 (2022) |
op_relation |
https://doi.org/10.1002/vms3.909 https://doaj.org/toc/2053-1095 2053-1095 doi:10.1002/vms3.909 https://doaj.org/article/10fa530a239246efa64ab0254ae67443 |
op_doi |
https://doi.org/10.1002/vms3.909 |
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Veterinary Medicine and Science |
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8 |
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6 |
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2678 |
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2682 |
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1781058755266347008 |