The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
Abstract The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestr...
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ftdoajarticles:oai:doaj.org/article:10d8e2668bb24a349061e03fda39a31d 2023-05-15T15:06:56+02:00 The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria Taramelli Donatella Mimche Patrice N Vivas Livia 2011-03-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-S1-S10 https://doaj.org/article/10d8e2668bb24a349061e03fda39a31d EN eng BMC http://www.malariajournal.com/content/10/S1/S10 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-S1-S10 1475-2875 https://doaj.org/article/10d8e2668bb24a349061e03fda39a31d Malaria Journal, Vol 10, Iss Suppl 1, p S10 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-S1-S10 2022-12-31T01:59:12Z Abstract The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestration and obstruction of brain capillaries. The consequent reduction in blood flow, leads to cerebral hypoxia, localized inflammation and release of neurotoxic molecules and inflammatory cytokines by the endothelium. The pharmacological regulation of these immunopathological processes by immunomodulatory molecules may potentially benefit the management of this severe complication. Adjunctive therapy of CM patients with an appropriate immunomodulatory compound possessing even moderate anti-malarial activity with the capacity to down regulate excess production of proinflammatory cytokines and expression of adhesion molecules, could potentially reverse cytoadherence, improve survival and prevent neurological sequelae. Current major drug discovery programmes are mainly focused on novel parasite targets and mechanisms of action. However, the discovery of compounds targeting the host remains a largely unexplored but attractive area of drug discovery research for the treatment of CM. This review discusses the properties of the plant immune-modifier curcumin and its potential as an adjunctive therapy for the management of this complication. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 S1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Taramelli Donatella Mimche Patrice N Vivas Livia The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract The clinical manifestations of cerebral malaria (CM) are well correlated with underlying major pathophysiological events occurring during an acute malaria infection, the most important of which, is the adherence of parasitized erythrocytes to endothelial cells ultimately leading to sequestration and obstruction of brain capillaries. The consequent reduction in blood flow, leads to cerebral hypoxia, localized inflammation and release of neurotoxic molecules and inflammatory cytokines by the endothelium. The pharmacological regulation of these immunopathological processes by immunomodulatory molecules may potentially benefit the management of this severe complication. Adjunctive therapy of CM patients with an appropriate immunomodulatory compound possessing even moderate anti-malarial activity with the capacity to down regulate excess production of proinflammatory cytokines and expression of adhesion molecules, could potentially reverse cytoadherence, improve survival and prevent neurological sequelae. Current major drug discovery programmes are mainly focused on novel parasite targets and mechanisms of action. However, the discovery of compounds targeting the host remains a largely unexplored but attractive area of drug discovery research for the treatment of CM. This review discusses the properties of the plant immune-modifier curcumin and its potential as an adjunctive therapy for the management of this complication. |
format |
Article in Journal/Newspaper |
author |
Taramelli Donatella Mimche Patrice N Vivas Livia |
author_facet |
Taramelli Donatella Mimche Patrice N Vivas Livia |
author_sort |
Taramelli Donatella |
title |
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
title_short |
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
title_full |
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
title_fullStr |
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
title_full_unstemmed |
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
title_sort |
plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-S1-S10 https://doaj.org/article/10d8e2668bb24a349061e03fda39a31d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss Suppl 1, p S10 (2011) |
op_relation |
http://www.malariajournal.com/content/10/S1/S10 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-S1-S10 1475-2875 https://doaj.org/article/10d8e2668bb24a349061e03fda39a31d |
op_doi |
https://doi.org/10.1186/1475-2875-10-S1-S10 |
container_title |
Malaria Journal |
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10 |
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S1 |
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1766338517767553024 |