Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation
Mannose-binding lectin (MBL) is a pattern recognizing acute-phase protein of the innate immunity system actively involved in the elimination of a wide range of pathogenic microorganisms by activating the lectin pathway of the complement system. A significant part of the human population has a congen...
Published in: | Vavilov Journal of Genetics and Breeding |
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Language: | English Russian |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2020
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Online Access: | https://doi.org/10.18699/VJ20.685 https://doaj.org/article/10aaf075781e4f7e99a1df3a33e0ac32 |
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ftdoajarticles:oai:doaj.org/article:10aaf075781e4f7e99a1df3a33e0ac32 2024-02-11T10:00:24+01:00 Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation S. Yu. Tereshchenko M. V. Smolnikova 2020-12-01T00:00:00Z https://doi.org/10.18699/VJ20.685 https://doaj.org/article/10aaf075781e4f7e99a1df3a33e0ac32 EN RU eng rus Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders https://vavilov.elpub.ru/jour/article/view/2847 https://doaj.org/toc/2500-3259 2500-3259 doi:10.18699/VJ20.685 https://doaj.org/article/10aaf075781e4f7e99a1df3a33e0ac32 Вавиловский журнал генетики и селекции, Vol 24, Iss 8, Pp 868-875 (2020) mbl2 gene polymorphism newborns russia arctic populations Genetics QH426-470 article 2020 ftdoajarticles https://doi.org/10.18699/VJ20.685 2024-01-14T01:50:19Z Mannose-binding lectin (MBL) is a pattern recognizing acute-phase protein of the innate immunity system actively involved in the elimination of a wide range of pathogenic microorganisms by activating the lectin pathway of the complement system. A significant part of the human population has a congenitally low production level and/or low MBL activity due to the carriage of various MBL2 variants, which can modify the course of a wide range of infectious diseases. The genotype and haplotype frequencies of the MBL2 polymorphisms have significant population differences. So far, data on the prevalence of the MBL2 genotypes in indigenous populations of the Russian Arctic regions have not been available. The aim of the study was to analyze the frequency and ethnic specificity of the distribution of allelic variants of the MBL2 polymorphisms rs11003125, rs7096206, rs7095891, rs5030737, rs1800450 and rs1800451 and their haplotypes in the populations of the Taimyr Dolgans-Nenets region of the Krasnoyarsk territory (Nenets, Dolgans-Nganasans, Russians). Data on the genotype and haplotype frequencies of the MBL2 gene among indigenous peoples of the Russian Arctic territories was first obtained in the study. The HYPA haplotype prevalence associated with a high concentration of MBL amounted to 35.4 % for Russian newborns in Eastern Siberia, corresponding to the one for European populations (27–33 %). In newborns of the Arctic populations, the prevalence of HYPA haplotype was significantly higher than in Russians and amounted to 64 % for Nenets and 56 % for the DolgansNganasans, which is close to the one detected for the Eskimos and North American Indians (64–81 %). Populations of Nenets and Dolgans-Nganasans demonstrated a significantly lower prevalence of MBL-deficient haplotypes compared with Caucasians of Eastern Siberia (3.9, 6.4 and 21.3 % respectively). Isolated Arctic populations were suggested to experience some intracellular infections (tuberculosis, leprosy) historically later and, unlike Caucasoid populations, to ... Article in Journal/Newspaper Arctic eskimo* nenets Nganasan* Taimyr Siberia Directory of Open Access Journals: DOAJ Articles Arctic Vavilov Journal of Genetics and Breeding 24 8 868 875 |
institution |
Open Polar |
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op_collection_id |
ftdoajarticles |
language |
English Russian |
topic |
mbl2 gene polymorphism newborns russia arctic populations Genetics QH426-470 |
spellingShingle |
mbl2 gene polymorphism newborns russia arctic populations Genetics QH426-470 S. Yu. Tereshchenko M. V. Smolnikova Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation |
topic_facet |
mbl2 gene polymorphism newborns russia arctic populations Genetics QH426-470 |
description |
Mannose-binding lectin (MBL) is a pattern recognizing acute-phase protein of the innate immunity system actively involved in the elimination of a wide range of pathogenic microorganisms by activating the lectin pathway of the complement system. A significant part of the human population has a congenitally low production level and/or low MBL activity due to the carriage of various MBL2 variants, which can modify the course of a wide range of infectious diseases. The genotype and haplotype frequencies of the MBL2 polymorphisms have significant population differences. So far, data on the prevalence of the MBL2 genotypes in indigenous populations of the Russian Arctic regions have not been available. The aim of the study was to analyze the frequency and ethnic specificity of the distribution of allelic variants of the MBL2 polymorphisms rs11003125, rs7096206, rs7095891, rs5030737, rs1800450 and rs1800451 and their haplotypes in the populations of the Taimyr Dolgans-Nenets region of the Krasnoyarsk territory (Nenets, Dolgans-Nganasans, Russians). Data on the genotype and haplotype frequencies of the MBL2 gene among indigenous peoples of the Russian Arctic territories was first obtained in the study. The HYPA haplotype prevalence associated with a high concentration of MBL amounted to 35.4 % for Russian newborns in Eastern Siberia, corresponding to the one for European populations (27–33 %). In newborns of the Arctic populations, the prevalence of HYPA haplotype was significantly higher than in Russians and amounted to 64 % for Nenets and 56 % for the DolgansNganasans, which is close to the one detected for the Eskimos and North American Indians (64–81 %). Populations of Nenets and Dolgans-Nganasans demonstrated a significantly lower prevalence of MBL-deficient haplotypes compared with Caucasians of Eastern Siberia (3.9, 6.4 and 21.3 % respectively). Isolated Arctic populations were suggested to experience some intracellular infections (tuberculosis, leprosy) historically later and, unlike Caucasoid populations, to ... |
format |
Article in Journal/Newspaper |
author |
S. Yu. Tereshchenko M. V. Smolnikova |
author_facet |
S. Yu. Tereshchenko M. V. Smolnikova |
author_sort |
S. Yu. Tereshchenko |
title |
Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation |
title_short |
Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation |
title_full |
Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation |
title_fullStr |
Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation |
title_full_unstemmed |
Polymorphism of the mannose-binding lectin gene in the Arctic indigenous populations of the Russian Federation |
title_sort |
polymorphism of the mannose-binding lectin gene in the arctic indigenous populations of the russian federation |
publisher |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
publishDate |
2020 |
url |
https://doi.org/10.18699/VJ20.685 https://doaj.org/article/10aaf075781e4f7e99a1df3a33e0ac32 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic eskimo* nenets Nganasan* Taimyr Siberia |
genre_facet |
Arctic eskimo* nenets Nganasan* Taimyr Siberia |
op_source |
Вавиловский журнал генетики и селекции, Vol 24, Iss 8, Pp 868-875 (2020) |
op_relation |
https://vavilov.elpub.ru/jour/article/view/2847 https://doaj.org/toc/2500-3259 2500-3259 doi:10.18699/VJ20.685 https://doaj.org/article/10aaf075781e4f7e99a1df3a33e0ac32 |
op_doi |
https://doi.org/10.18699/VJ20.685 |
container_title |
Vavilov Journal of Genetics and Breeding |
container_volume |
24 |
container_issue |
8 |
container_start_page |
868 |
op_container_end_page |
875 |
_version_ |
1790596105772204032 |