Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia
Abstract Background Analysis of anti-malarial antibody responses has the potential to improve characterization of the variation in exposure to infection in low transmission settings, where conventional measures, such as entomological estimates and parasitaemia point prevalence become less sensitive...
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ftdoajarticles:oai:doaj.org/article:10a92c13a0cc404d8a2e37bbe9dffb24 2023-05-15T15:17:42+02:00 Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia Henry Surendra Mahardika A. Wijayanti Elsa H. Murhandarwati Irnawati Titik Yuniarti Mardiati Herdiana Maria E. Sumiwi William A. Hawley Neil F. Lobo Jackie Cook Chris Drakeley Supargiyono 2019-07-01T00:00:00Z https://doi.org/10.1186/s12936-019-2866-z https://doaj.org/article/10a92c13a0cc404d8a2e37bbe9dffb24 EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2866-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2866-z 1475-2875 https://doaj.org/article/10a92c13a0cc404d8a2e37bbe9dffb24 Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019) Serology Epidemiology Surveillance Malaria P. falciparum P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2866-z 2022-12-31T13:47:49Z Abstract Background Analysis of anti-malarial antibody responses has the potential to improve characterization of the variation in exposure to infection in low transmission settings, where conventional measures, such as entomological estimates and parasitaemia point prevalence become less sensitive and expensive to measure. This study evaluates the use of sero-epidemiological analysis to investigate heterogeneity of transmission in area conducting elimination in Indonesia. Methods Filter paper bloodspots and epidemiological data were collected through a community-based cross-sectional study conducted in two sub-districts in Sabang municipality, Aceh province, Indonesia in 2013. Antibody responses to merozoite surface protein 1 (MSP-119) and apical membrane antigen 1 (AMA-1) for Plasmodium falciparum and Plasmodium vivax were measured using indirect enzyme-linked immunosorbent assay (ELISA). Seroconversion rates (SCR) were estimated by fitting a simple reversible catalytic model to seroprevalence data for each antibody. Spatial analysis was performed using a Normal model (SaTScan v.9.4.2) to identify the clustering of higher values of household antibody responses. Multiple logistic regression was used to investigate factors associated with exposure. Results 1624 samples were collected from 605 households. Seroprevalence to any P. falciparum antigen was higher than to any P. vivax antigen, 6.9% (95% CI 5.8–8.2) vs 2.0% (95% CI 1.4–2.8). SCR estimates suggest that there was a significant change in P. falciparum transmission with no exposure seen in children under 5 years old. Plasmodium falciparum SCR in over 5 years old was 0.008 (95% CI 0.003–0.017) and 0.012 (95% CI 0.005–0.030) in Sukakarya and Sukajaya sub-districts, respectively. Clusters of exposure were detected for both P. falciparum and P. vivax, most of them in Sukajaya sub-district. Higher age, P. vivax seropositivity and use of long-lasting insecticide-treated bed net (LLIN) were associated with higher P. falciparum exposure. Conclusion Analysis of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Serology Epidemiology Surveillance Malaria P. falciparum P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Serology Epidemiology Surveillance Malaria P. falciparum P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Henry Surendra Mahardika A. Wijayanti Elsa H. Murhandarwati Irnawati Titik Yuniarti Mardiati Herdiana Maria E. Sumiwi William A. Hawley Neil F. Lobo Jackie Cook Chris Drakeley Supargiyono Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia |
topic_facet |
Serology Epidemiology Surveillance Malaria P. falciparum P. vivax Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Analysis of anti-malarial antibody responses has the potential to improve characterization of the variation in exposure to infection in low transmission settings, where conventional measures, such as entomological estimates and parasitaemia point prevalence become less sensitive and expensive to measure. This study evaluates the use of sero-epidemiological analysis to investigate heterogeneity of transmission in area conducting elimination in Indonesia. Methods Filter paper bloodspots and epidemiological data were collected through a community-based cross-sectional study conducted in two sub-districts in Sabang municipality, Aceh province, Indonesia in 2013. Antibody responses to merozoite surface protein 1 (MSP-119) and apical membrane antigen 1 (AMA-1) for Plasmodium falciparum and Plasmodium vivax were measured using indirect enzyme-linked immunosorbent assay (ELISA). Seroconversion rates (SCR) were estimated by fitting a simple reversible catalytic model to seroprevalence data for each antibody. Spatial analysis was performed using a Normal model (SaTScan v.9.4.2) to identify the clustering of higher values of household antibody responses. Multiple logistic regression was used to investigate factors associated with exposure. Results 1624 samples were collected from 605 households. Seroprevalence to any P. falciparum antigen was higher than to any P. vivax antigen, 6.9% (95% CI 5.8–8.2) vs 2.0% (95% CI 1.4–2.8). SCR estimates suggest that there was a significant change in P. falciparum transmission with no exposure seen in children under 5 years old. Plasmodium falciparum SCR in over 5 years old was 0.008 (95% CI 0.003–0.017) and 0.012 (95% CI 0.005–0.030) in Sukakarya and Sukajaya sub-districts, respectively. Clusters of exposure were detected for both P. falciparum and P. vivax, most of them in Sukajaya sub-district. Higher age, P. vivax seropositivity and use of long-lasting insecticide-treated bed net (LLIN) were associated with higher P. falciparum exposure. Conclusion Analysis of ... |
format |
Article in Journal/Newspaper |
author |
Henry Surendra Mahardika A. Wijayanti Elsa H. Murhandarwati Irnawati Titik Yuniarti Mardiati Herdiana Maria E. Sumiwi William A. Hawley Neil F. Lobo Jackie Cook Chris Drakeley Supargiyono |
author_facet |
Henry Surendra Mahardika A. Wijayanti Elsa H. Murhandarwati Irnawati Titik Yuniarti Mardiati Herdiana Maria E. Sumiwi William A. Hawley Neil F. Lobo Jackie Cook Chris Drakeley Supargiyono |
author_sort |
Henry Surendra |
title |
Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia |
title_short |
Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia |
title_full |
Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia |
title_fullStr |
Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia |
title_full_unstemmed |
Analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in Indonesia |
title_sort |
analysis of serological data to investigate heterogeneity of malaria transmission: a community-based cross-sectional study in an area conducting elimination in indonesia |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2866-z https://doaj.org/article/10a92c13a0cc404d8a2e37bbe9dffb24 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-12 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2866-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2866-z 1475-2875 https://doaj.org/article/10a92c13a0cc404d8a2e37bbe9dffb24 |
op_doi |
https://doi.org/10.1186/s12936-019-2866-z |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766347943402536960 |