Simulation of malaria epidemiology and control in the highlands of western Kenya
Abstract Background Models of Plasmodium falciparum malaria epidemiology that provide realistic quantitative predictions of likely epidemiological outcomes of existing vector control strategies have the potential to assist in planning for the control and elimination of malaria. This work investigate...
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ftdoajarticles:oai:doaj.org/article:100b37809e3b40a3a5581baf1da26232 2023-05-15T15:14:52+02:00 Simulation of malaria epidemiology and control in the highlands of western Kenya Stuckey Erin M Stevenson Jennifer C Cooke Mary K Owaga Chrispin Marube Elizabeth Oando George Hardy Diggory Drakeley Chris Smith Thomas A Cox Jonathan Chitnis Nakul 2012-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-357 https://doaj.org/article/100b37809e3b40a3a5581baf1da26232 EN eng BMC http://www.malariajournal.com/content/11/1/357 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-357 1475-2875 https://doaj.org/article/100b37809e3b40a3a5581baf1da26232 Malaria Journal, Vol 11, Iss 1, p 357 (2012) Simulation Kenya EIR Mathematical Modelling Sensitivity analysis Malaria OpenMalaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-357 2022-12-31T13:11:18Z Abstract Background Models of Plasmodium falciparum malaria epidemiology that provide realistic quantitative predictions of likely epidemiological outcomes of existing vector control strategies have the potential to assist in planning for the control and elimination of malaria. This work investigates the applicability of mathematical modelling of malaria transmission dynamics in Rachuonyo South, a district with low, unstable transmission in the highlands of western Kenya. Methods Individual-based stochastic simulation models of malaria in humans and a deterministic model of malaria in mosquitoes as part of the OpenMalaria platform were parameterized to create a scenario for the study area based on data from ongoing field studies and available literature. The scenario was simulated for a period of two years with a population of 10,000 individuals and validated against malaria survey data from Rachuonyo South. Simulations were repeated with multiple random seeds and an ensemble of 14 model variants to address stochasticity and model uncertainty. A one-dimensional sensitivity analysis was conducted to address parameter uncertainty. Results The scenario was able to reproduce the seasonal pattern of the entomological inoculation rate (EIR) and patent infections observed in an all-age cohort of individuals sampled monthly for one year. Using an EIR estimated from serology to parameterize the scenario resulted in a closer fit to parasite prevalence than an EIR estimated using entomological methods. The scenario parameterization was most sensitive to changes in the timing and effectiveness of indoor residual spraying (IRS) and the method used to detect P. falciparum in humans. It was less sensitive than expected to changes in vector biting behaviour and climatic patterns. Conclusions The OpenMalaria model of P. falciparum transmission can be used to simulate the impact of different combinations of current and potential control interventions to help plan malaria control in this low transmission setting. In this setting ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Simulation Kenya EIR Mathematical Modelling Sensitivity analysis Malaria OpenMalaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Simulation Kenya EIR Mathematical Modelling Sensitivity analysis Malaria OpenMalaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Stuckey Erin M Stevenson Jennifer C Cooke Mary K Owaga Chrispin Marube Elizabeth Oando George Hardy Diggory Drakeley Chris Smith Thomas A Cox Jonathan Chitnis Nakul Simulation of malaria epidemiology and control in the highlands of western Kenya |
topic_facet |
Simulation Kenya EIR Mathematical Modelling Sensitivity analysis Malaria OpenMalaria Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Models of Plasmodium falciparum malaria epidemiology that provide realistic quantitative predictions of likely epidemiological outcomes of existing vector control strategies have the potential to assist in planning for the control and elimination of malaria. This work investigates the applicability of mathematical modelling of malaria transmission dynamics in Rachuonyo South, a district with low, unstable transmission in the highlands of western Kenya. Methods Individual-based stochastic simulation models of malaria in humans and a deterministic model of malaria in mosquitoes as part of the OpenMalaria platform were parameterized to create a scenario for the study area based on data from ongoing field studies and available literature. The scenario was simulated for a period of two years with a population of 10,000 individuals and validated against malaria survey data from Rachuonyo South. Simulations were repeated with multiple random seeds and an ensemble of 14 model variants to address stochasticity and model uncertainty. A one-dimensional sensitivity analysis was conducted to address parameter uncertainty. Results The scenario was able to reproduce the seasonal pattern of the entomological inoculation rate (EIR) and patent infections observed in an all-age cohort of individuals sampled monthly for one year. Using an EIR estimated from serology to parameterize the scenario resulted in a closer fit to parasite prevalence than an EIR estimated using entomological methods. The scenario parameterization was most sensitive to changes in the timing and effectiveness of indoor residual spraying (IRS) and the method used to detect P. falciparum in humans. It was less sensitive than expected to changes in vector biting behaviour and climatic patterns. Conclusions The OpenMalaria model of P. falciparum transmission can be used to simulate the impact of different combinations of current and potential control interventions to help plan malaria control in this low transmission setting. In this setting ... |
format |
Article in Journal/Newspaper |
author |
Stuckey Erin M Stevenson Jennifer C Cooke Mary K Owaga Chrispin Marube Elizabeth Oando George Hardy Diggory Drakeley Chris Smith Thomas A Cox Jonathan Chitnis Nakul |
author_facet |
Stuckey Erin M Stevenson Jennifer C Cooke Mary K Owaga Chrispin Marube Elizabeth Oando George Hardy Diggory Drakeley Chris Smith Thomas A Cox Jonathan Chitnis Nakul |
author_sort |
Stuckey Erin M |
title |
Simulation of malaria epidemiology and control in the highlands of western Kenya |
title_short |
Simulation of malaria epidemiology and control in the highlands of western Kenya |
title_full |
Simulation of malaria epidemiology and control in the highlands of western Kenya |
title_fullStr |
Simulation of malaria epidemiology and control in the highlands of western Kenya |
title_full_unstemmed |
Simulation of malaria epidemiology and control in the highlands of western Kenya |
title_sort |
simulation of malaria epidemiology and control in the highlands of western kenya |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-357 https://doaj.org/article/100b37809e3b40a3a5581baf1da26232 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 357 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/357 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-357 1475-2875 https://doaj.org/article/100b37809e3b40a3a5581baf1da26232 |
op_doi |
https://doi.org/10.1186/1475-2875-11-357 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
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1766345267816169472 |