Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania.
BACKGROUND: Porcine cysticercosis is caused by a zoonotic tapeworm, Taenia solium, which causes serious disease syndromes in human. Effective control of the parasite requires knowledge on the burden and pattern of the infections in order to properly direct limited resources. The objective of this st...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0000652 https://doaj.org/article/0fdd79f793294caea20a7c939cee67ed |
id |
ftdoajarticles:oai:doaj.org/article:0fdd79f793294caea20a7c939cee67ed |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0fdd79f793294caea20a7c939cee67ed 2023-05-15T15:16:34+02:00 Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. Helena A Ngowi Ayub A Kassuku Hélène Carabin James E D Mlangwa Malongo R S Mlozi Boniface P Mbilinyi Arve L Willingham 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000652 https://doaj.org/article/0fdd79f793294caea20a7c939cee67ed EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2850315?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000652 https://doaj.org/article/0fdd79f793294caea20a7c939cee67ed PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e652 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000652 2022-12-31T01:57:34Z BACKGROUND: Porcine cysticercosis is caused by a zoonotic tapeworm, Taenia solium, which causes serious disease syndromes in human. Effective control of the parasite requires knowledge on the burden and pattern of the infections in order to properly direct limited resources. The objective of this study was to establish the spatial distribution of porcine cysticercosis in Mbulu district, northern Tanzania, to guide control strategies. METHODOLOGY/PRINCIPAL FINDINGS: This study is a secondary analysis of data collected during the baseline and follow-up periods of a randomized community trial aiming at reducing the incidence rate of porcine cysticercosis through an educational program. At baseline, 784 randomly selected pig-keeping households located in 42 villages in 14 wards were included. Lingual examination of indigenous pigs aged 2-12 (median 8) months, one randomly selected from each household, were conducted. Data from the control group of the randomized trial that included 21 of the 42 villages were used for the incidence study. A total of 295 pig-keeping households were provided with sentinel pigs (one each) and reassessed for cysticercosis incidence once or twice for 2-9 (median 4) months using lingual examination and antigen ELISA. Prevalence of porcine cysticercosis was computed in Epi Info 3.5. The prevalence and incidence of porcine cysticercosis were mapped at household level using ArcView 3.2. K functions were computed in R software to assess general clustering of porcine cysticercosis. Spatial scan statistics were computed in SatScan to identify local clusters of the infection. The overall prevalence of porcine cysticercosis was 7.3% (95% CI: 5.6, 9.4; n = 784). The K functions revealed a significant overall clustering of porcine cysticercosis incidence for all distances between 600 m and 5 km from a randomly chosen case household based on Ag-ELISA. Lingual examination revealed clustering from 650 m to 6 km and between 7.5 and 10 km. The prevalence study did not reveal any significant clustering by ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 4 e652 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Helena A Ngowi Ayub A Kassuku Hélène Carabin James E D Mlangwa Malongo R S Mlozi Boniface P Mbilinyi Arve L Willingham Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Porcine cysticercosis is caused by a zoonotic tapeworm, Taenia solium, which causes serious disease syndromes in human. Effective control of the parasite requires knowledge on the burden and pattern of the infections in order to properly direct limited resources. The objective of this study was to establish the spatial distribution of porcine cysticercosis in Mbulu district, northern Tanzania, to guide control strategies. METHODOLOGY/PRINCIPAL FINDINGS: This study is a secondary analysis of data collected during the baseline and follow-up periods of a randomized community trial aiming at reducing the incidence rate of porcine cysticercosis through an educational program. At baseline, 784 randomly selected pig-keeping households located in 42 villages in 14 wards were included. Lingual examination of indigenous pigs aged 2-12 (median 8) months, one randomly selected from each household, were conducted. Data from the control group of the randomized trial that included 21 of the 42 villages were used for the incidence study. A total of 295 pig-keeping households were provided with sentinel pigs (one each) and reassessed for cysticercosis incidence once or twice for 2-9 (median 4) months using lingual examination and antigen ELISA. Prevalence of porcine cysticercosis was computed in Epi Info 3.5. The prevalence and incidence of porcine cysticercosis were mapped at household level using ArcView 3.2. K functions were computed in R software to assess general clustering of porcine cysticercosis. Spatial scan statistics were computed in SatScan to identify local clusters of the infection. The overall prevalence of porcine cysticercosis was 7.3% (95% CI: 5.6, 9.4; n = 784). The K functions revealed a significant overall clustering of porcine cysticercosis incidence for all distances between 600 m and 5 km from a randomly chosen case household based on Ag-ELISA. Lingual examination revealed clustering from 650 m to 6 km and between 7.5 and 10 km. The prevalence study did not reveal any significant clustering by ... |
format |
Article in Journal/Newspaper |
author |
Helena A Ngowi Ayub A Kassuku Hélène Carabin James E D Mlangwa Malongo R S Mlozi Boniface P Mbilinyi Arve L Willingham |
author_facet |
Helena A Ngowi Ayub A Kassuku Hélène Carabin James E D Mlangwa Malongo R S Mlozi Boniface P Mbilinyi Arve L Willingham |
author_sort |
Helena A Ngowi |
title |
Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. |
title_short |
Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. |
title_full |
Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. |
title_fullStr |
Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. |
title_full_unstemmed |
Spatial clustering of porcine cysticercosis in Mbulu district, northern Tanzania. |
title_sort |
spatial clustering of porcine cysticercosis in mbulu district, northern tanzania. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000652 https://doaj.org/article/0fdd79f793294caea20a7c939cee67ed |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e652 (2010) |
op_relation |
http://europepmc.org/articles/PMC2850315?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000652 https://doaj.org/article/0fdd79f793294caea20a7c939cee67ed |
op_doi |
https://doi.org/10.1371/journal.pntd.0000652 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
4 |
container_issue |
4 |
container_start_page |
e652 |
_version_ |
1766346863953313792 |