Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi
Abstract INTRODUCTION: Enriched environments normally increase behavioral repertoires and diminish the expression of abnormal behaviors and stress-related physiological problems in animals. Although it has been shown that experimental animals infected with microorganisms can modify their behaviors a...
Published in: | Revista da Sociedade Brasileira de Medicina Tropical |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Sociedade Brasileira de Medicina Tropical (SBMT)
|
Subjects: | |
Online Access: | https://doi.org/10.1590/0037-8682-0536-2016 https://doaj.org/article/0fcf0e62f24548c2854ca77a226e2543 |
id |
ftdoajarticles:oai:doaj.org/article:0fcf0e62f24548c2854ca77a226e2543 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0fcf0e62f24548c2854ca77a226e2543 2023-05-15T15:08:55+02:00 Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi Déborah Maria Moreira da Silva Laila Pinheiro Cristiano Schetini Azevedo Guilherme de Paula Costa André Talvani https://doi.org/10.1590/0037-8682-0536-2016 https://doaj.org/article/0fcf0e62f24548c2854ca77a226e2543 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300341&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0536-2016 https://doaj.org/article/0fcf0e62f24548c2854ca77a226e2543 Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 3, Pp 341-349 Chagas disease Inflammation Laboratory animals Welfare Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0536-2016 2022-12-30T23:22:44Z Abstract INTRODUCTION: Enriched environments normally increase behavioral repertoires and diminish the expression of abnormal behaviors and stress-related physiological problems in animals. Although it has been shown that experimental animals infected with microorganisms can modify their behaviors and physiology, few studies have evaluated how environmental enrichment affects these parameters. This study aimed to evaluate the effects of environmental enrichment on the behavior and physiology of confined mice infected with Trypanosoma cruzi. METHODS: The behaviors of 20 T. cruzi-infected mice and 20 non-infected mice were recorded during three treatments: baseline, enrichment, and post-enrichment. Behavioral data were collected using scan sampling with instantaneous recording of behavior every 30s, totaling 360h. Plasma TNF, CCL2, and IL-10 levels and parasitemia were also evaluated in infected enriched/non-enriched mice. Behavioral data were evaluated by Friedman’s test and physiological data by one-way ANOVA and area under the curve (AUC) analysis. RESULTS: Results showed that environmental enrichment significantly increased exploratory behaviors and diminished inactivity. The use of environmental enrichment did not diminish circulating levels of TNF and IL-10 but diminished circulating levels of CCL2 and parasitemia. CONCLUSIONS: Positive behavioral and physiological effects of environmental enrichment were observed in mice living in enriched cages. Thus, environmental enrichment improved the welfare of these animals. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 3 341 349 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chagas disease Inflammation Laboratory animals Welfare Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Chagas disease Inflammation Laboratory animals Welfare Arctic medicine. Tropical medicine RC955-962 Déborah Maria Moreira da Silva Laila Pinheiro Cristiano Schetini Azevedo Guilherme de Paula Costa André Talvani Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi |
topic_facet |
Chagas disease Inflammation Laboratory animals Welfare Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract INTRODUCTION: Enriched environments normally increase behavioral repertoires and diminish the expression of abnormal behaviors and stress-related physiological problems in animals. Although it has been shown that experimental animals infected with microorganisms can modify their behaviors and physiology, few studies have evaluated how environmental enrichment affects these parameters. This study aimed to evaluate the effects of environmental enrichment on the behavior and physiology of confined mice infected with Trypanosoma cruzi. METHODS: The behaviors of 20 T. cruzi-infected mice and 20 non-infected mice were recorded during three treatments: baseline, enrichment, and post-enrichment. Behavioral data were collected using scan sampling with instantaneous recording of behavior every 30s, totaling 360h. Plasma TNF, CCL2, and IL-10 levels and parasitemia were also evaluated in infected enriched/non-enriched mice. Behavioral data were evaluated by Friedman’s test and physiological data by one-way ANOVA and area under the curve (AUC) analysis. RESULTS: Results showed that environmental enrichment significantly increased exploratory behaviors and diminished inactivity. The use of environmental enrichment did not diminish circulating levels of TNF and IL-10 but diminished circulating levels of CCL2 and parasitemia. CONCLUSIONS: Positive behavioral and physiological effects of environmental enrichment were observed in mice living in enriched cages. Thus, environmental enrichment improved the welfare of these animals. |
format |
Article in Journal/Newspaper |
author |
Déborah Maria Moreira da Silva Laila Pinheiro Cristiano Schetini Azevedo Guilherme de Paula Costa André Talvani |
author_facet |
Déborah Maria Moreira da Silva Laila Pinheiro Cristiano Schetini Azevedo Guilherme de Paula Costa André Talvani |
author_sort |
Déborah Maria Moreira da Silva |
title |
Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi |
title_short |
Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi |
title_full |
Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi |
title_fullStr |
Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi |
title_full_unstemmed |
Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi |
title_sort |
influence of environmental enrichment on the behavior and physiology of mice infected by trypanosoma cruzi |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0536-2016 https://doaj.org/article/0fcf0e62f24548c2854ca77a226e2543 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 3, Pp 341-349 |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017002300341&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0536-2016 https://doaj.org/article/0fcf0e62f24548c2854ca77a226e2543 |
op_doi |
https://doi.org/10.1590/0037-8682-0536-2016 |
container_title |
Revista da Sociedade Brasileira de Medicina Tropical |
container_volume |
50 |
container_issue |
3 |
container_start_page |
341 |
op_container_end_page |
349 |
_version_ |
1766340187295580160 |