Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination
We evaluated the immunogenicity of three recombinant hepatitis B vaccines, one Brazilian (Butang, Instituto Butantan) and two Korean vaccines (Euvax-B, LG Chemical Ltd. and Hepavax-Gene, Greencross Vaccine Corp.), administered intramuscularly to students aged 17 to 19 years in three 10-µg doses (cor...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:0f8b6bf9ad734c21a2352d130a8f6833 2024-09-09T19:27:46+00:00 Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination Baldy José Luís da Silveira Lima Gerson Zanetta de Morimoto Helena Kaminami Reiche Edna Maria Vissoci Matsuo Tiemi Mattos Edlivia Dias de Sudan Luci Cristina Pulga 2004-01-01T00:00:00Z https://doaj.org/article/0f8b6bf9ad734c21a2352d130a8f6833 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000200009 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/0f8b6bf9ad734c21a2352d130a8f6833 Revista do Instituto de Medicina Tropical de São Paulo, Vol 46, Iss 2, Pp 103-107 (2004) Recombinant hepatitis B vaccines Immunogenicity Adverse effects Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2004 ftdoajarticles 2024-08-05T17:49:30Z We evaluated the immunogenicity of three recombinant hepatitis B vaccines, one Brazilian (Butang, Instituto Butantan) and two Korean vaccines (Euvax-B, LG Chemical Ltd. and Hepavax-Gene, Greencross Vaccine Corp.), administered intramuscularly to students aged 17 to 19 years in three 10-µg doses (corresponding to half the amount of antigen routinely used for adult vaccination) at intervals of one month between the first and second dose, and of four months between the second and third dose. A total of 316 students non-reactive for any serological marker of hepatitis B virus infection were vaccinated: 77 (24.4%) with the Butang vaccine, 71 (22.5%) with Euvax-B, 85 (26.9%) with Hepavax-Gene and, for comparison, 83 (26.2%) with Engerix-B (GlaxoSmithKline), whose efficacy in young adults at the dose used here has been confirmed in previous studies. Similar seroconversion rates (anti-HBs > 10 mIU/mL about one month after application of the third dose) were obtained for the Butang, Euvax-B, Hepavax-Gene and Engerix-B vaccines (96.2%, 98.6%, 96.5% and 97.6%, respectively). The frequency of good responders (anti-HBs > 100 mIU/mL) was also similar among students receiving the four vaccines (85.8%, 91.6%, 89.4% and 89.2%, respectively). The geometric mean titers (GMT) of anti-HBs about one month after the third dose obtained with these vaccines were 727.78 ± 6.46 mIU/mL, 2009.09 ± 7.16 mIU/mL, 1729.82 ± 8.85 mIU/mL and 2070.14 ± 11.69 mIU/mL, respectively. The GMT of anti-HBs induced by the Euvax-B and Engerix-B vaccines were higher than those obtained with the Butang vaccine (p < 0.05); this difference was not significant when comparing the other vaccines two-by-two. No spontaneous adverse effects attributable to the application of any dose of the four vaccines were reported. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Recombinant hepatitis B vaccines Immunogenicity Adverse effects Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Recombinant hepatitis B vaccines Immunogenicity Adverse effects Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Baldy José Luís da Silveira Lima Gerson Zanetta de Morimoto Helena Kaminami Reiche Edna Maria Vissoci Matsuo Tiemi Mattos Edlivia Dias de Sudan Luci Cristina Pulga Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
topic_facet |
Recombinant hepatitis B vaccines Immunogenicity Adverse effects Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
We evaluated the immunogenicity of three recombinant hepatitis B vaccines, one Brazilian (Butang, Instituto Butantan) and two Korean vaccines (Euvax-B, LG Chemical Ltd. and Hepavax-Gene, Greencross Vaccine Corp.), administered intramuscularly to students aged 17 to 19 years in three 10-µg doses (corresponding to half the amount of antigen routinely used for adult vaccination) at intervals of one month between the first and second dose, and of four months between the second and third dose. A total of 316 students non-reactive for any serological marker of hepatitis B virus infection were vaccinated: 77 (24.4%) with the Butang vaccine, 71 (22.5%) with Euvax-B, 85 (26.9%) with Hepavax-Gene and, for comparison, 83 (26.2%) with Engerix-B (GlaxoSmithKline), whose efficacy in young adults at the dose used here has been confirmed in previous studies. Similar seroconversion rates (anti-HBs > 10 mIU/mL about one month after application of the third dose) were obtained for the Butang, Euvax-B, Hepavax-Gene and Engerix-B vaccines (96.2%, 98.6%, 96.5% and 97.6%, respectively). The frequency of good responders (anti-HBs > 100 mIU/mL) was also similar among students receiving the four vaccines (85.8%, 91.6%, 89.4% and 89.2%, respectively). The geometric mean titers (GMT) of anti-HBs about one month after the third dose obtained with these vaccines were 727.78 ± 6.46 mIU/mL, 2009.09 ± 7.16 mIU/mL, 1729.82 ± 8.85 mIU/mL and 2070.14 ± 11.69 mIU/mL, respectively. The GMT of anti-HBs induced by the Euvax-B and Engerix-B vaccines were higher than those obtained with the Butang vaccine (p < 0.05); this difference was not significant when comparing the other vaccines two-by-two. No spontaneous adverse effects attributable to the application of any dose of the four vaccines were reported. |
format |
Article in Journal/Newspaper |
author |
Baldy José Luís da Silveira Lima Gerson Zanetta de Morimoto Helena Kaminami Reiche Edna Maria Vissoci Matsuo Tiemi Mattos Edlivia Dias de Sudan Luci Cristina Pulga |
author_facet |
Baldy José Luís da Silveira Lima Gerson Zanetta de Morimoto Helena Kaminami Reiche Edna Maria Vissoci Matsuo Tiemi Mattos Edlivia Dias de Sudan Luci Cristina Pulga |
author_sort |
Baldy José Luís da Silveira |
title |
Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
title_short |
Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
title_full |
Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
title_fullStr |
Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
title_full_unstemmed |
Immunogenicity of three recombinant hepatitis B vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
title_sort |
immunogenicity of three recombinant hepatitis b vaccines administered to students in three doses containing half the antigen amount routinely used for adult vaccination |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2004 |
url |
https://doaj.org/article/0f8b6bf9ad734c21a2352d130a8f6833 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 46, Iss 2, Pp 103-107 (2004) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000200009 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/0f8b6bf9ad734c21a2352d130a8f6833 |
_version_ |
1809897128904884224 |