Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin
Abstract Background This study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. Me...
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ftdoajarticles:oai:doaj.org/article:0f7794849a2e44cfbc1148a58800a6bc 2023-05-15T15:15:15+02:00 Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin Akogbéto Martin Chandre Fabrice Bangana Sahabi B Corbel Vincent Rogier Christophe Djènontin Armel Damien Georgia B Kindé-Gazard Dorothée Massougbodji Achille Henry Marie-Claire 2010-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-380 https://doaj.org/article/0f7794849a2e44cfbc1148a58800a6bc EN eng BMC http://www.malariajournal.com/content/9/1/380 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-380 1475-2875 https://doaj.org/article/0f7794849a2e44cfbc1148a58800a6bc Malaria Journal, Vol 9, Iss 1, p 380 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-380 2022-12-31T05:01:01Z Abstract Background This study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. Methods Between December 2007 and December 2008 in the health district of Ouidah - Kpomassè - Tori Bossito (southern Benin), a descriptive epidemiological survey of malaria was conducted. From 28 selected villages, seven were randomized from which a total of 440 children aged 0 to 5 years were randomly selected. Clinical and parasitological information was obtained by active case detection of malaria episodes carried out during eight periods of six consecutive days scheduled at six weekly intervals and by cross-sectional surveys of asymptomatic infection. Entomological information was also collected. The ownership, the use and the correct use of long-lasting insecticide-treated nets (LLINs) were checked over weekly-survey by unannounced visits at home in the late evening. Results Mean parasite density in asymptomatic children was 586 P. falciparum asexual forms per μL of blood (95%CI 504-680). Pyrogenic parasite cut-off was estimated 2,000 P. falciparum asexual blood forms per μL. The clinical incidence of malaria was 1.5 episodes per child per year (95%CI 1.2-1.9). Parasitological and clinical variables did not vary with season. Anopheles gambiae s.l . was the principal vector closely followed by Anopheles funestus . Entomological inoculation rate was 5.3 (95%CI 1.1-25.9) infective bites per human per year. Frequency of the L1014F kdr (West) allele was around 50%. Annual prevalence rate of Plasmodium falciparum asymptomatic infection was 21.8% (95%CI 19.1-24.4) and increased according to age. Mean rates of ownership and use of LLINs were 92% and 70% respectively. The only correct use of LLINs (63%) conferred 26% individual protection against only infection (OR = 0.74 (95%IC 0.62-0.87), p = 0.005). Conclusion The health ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Akogbéto Martin Chandre Fabrice Bangana Sahabi B Corbel Vincent Rogier Christophe Djènontin Armel Damien Georgia B Kindé-Gazard Dorothée Massougbodji Achille Henry Marie-Claire Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background This study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. The burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. Methods Between December 2007 and December 2008 in the health district of Ouidah - Kpomassè - Tori Bossito (southern Benin), a descriptive epidemiological survey of malaria was conducted. From 28 selected villages, seven were randomized from which a total of 440 children aged 0 to 5 years were randomly selected. Clinical and parasitological information was obtained by active case detection of malaria episodes carried out during eight periods of six consecutive days scheduled at six weekly intervals and by cross-sectional surveys of asymptomatic infection. Entomological information was also collected. The ownership, the use and the correct use of long-lasting insecticide-treated nets (LLINs) were checked over weekly-survey by unannounced visits at home in the late evening. Results Mean parasite density in asymptomatic children was 586 P. falciparum asexual forms per μL of blood (95%CI 504-680). Pyrogenic parasite cut-off was estimated 2,000 P. falciparum asexual blood forms per μL. The clinical incidence of malaria was 1.5 episodes per child per year (95%CI 1.2-1.9). Parasitological and clinical variables did not vary with season. Anopheles gambiae s.l . was the principal vector closely followed by Anopheles funestus . Entomological inoculation rate was 5.3 (95%CI 1.1-25.9) infective bites per human per year. Frequency of the L1014F kdr (West) allele was around 50%. Annual prevalence rate of Plasmodium falciparum asymptomatic infection was 21.8% (95%CI 19.1-24.4) and increased according to age. Mean rates of ownership and use of LLINs were 92% and 70% respectively. The only correct use of LLINs (63%) conferred 26% individual protection against only infection (OR = 0.74 (95%IC 0.62-0.87), p = 0.005). Conclusion The health ... |
format |
Article in Journal/Newspaper |
author |
Akogbéto Martin Chandre Fabrice Bangana Sahabi B Corbel Vincent Rogier Christophe Djènontin Armel Damien Georgia B Kindé-Gazard Dorothée Massougbodji Achille Henry Marie-Claire |
author_facet |
Akogbéto Martin Chandre Fabrice Bangana Sahabi B Corbel Vincent Rogier Christophe Djènontin Armel Damien Georgia B Kindé-Gazard Dorothée Massougbodji Achille Henry Marie-Claire |
author_sort |
Akogbéto Martin |
title |
Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin |
title_short |
Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin |
title_full |
Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin |
title_fullStr |
Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin |
title_full_unstemmed |
Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin |
title_sort |
malaria infection and disease in an area with pyrethroid-resistant vectors in southern benin |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-380 https://doaj.org/article/0f7794849a2e44cfbc1148a58800a6bc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 380 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/380 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-380 1475-2875 https://doaj.org/article/0f7794849a2e44cfbc1148a58800a6bc |
op_doi |
https://doi.org/10.1186/1475-2875-9-380 |
container_title |
Malaria Journal |
container_volume |
9 |
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1 |
_version_ |
1766345622839885824 |