Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study
Abstract Background The presence of malaria parasites and histopathological changes in the placenta are associated with a reduction in birth weight, principally due to intrauterine growth restriction. The aim of this study was to examine the feasibility of studying early pregnancy placental volumes...
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ftdoajarticles:oai:doaj.org/article:0f764ad1e7b24cda9f6063ae6f21ed95 2023-05-15T15:15:34+02:00 Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study Rijken Marcus J Moroski William E Kiricharoen Suporn Karunkonkowit Noaeni Stevenson Gordon Ohuma Eric O Noble J Alison Kennedy Stephen H McGready Rose Papageorghiou Aris T Nosten François H 2012-01-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-5 https://doaj.org/article/0f764ad1e7b24cda9f6063ae6f21ed95 EN eng BMC http://www.malariajournal.com/content/11/1/5 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-5 1475-2875 https://doaj.org/article/0f764ad1e7b24cda9f6063ae6f21ed95 Malaria Journal, Vol 11, Iss 1, p 5 (2012) Malaria Pregnancy Three-dimensional ultrasound Placenta volume IUGR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-5 2022-12-30T22:51:11Z Abstract Background The presence of malaria parasites and histopathological changes in the placenta are associated with a reduction in birth weight, principally due to intrauterine growth restriction. The aim of this study was to examine the feasibility of studying early pregnancy placental volumes using three-dimensional (3D) ultrasound in a malaria endemic area, as a small volume in the second trimester may be an indicator of intra-uterine growth restriction and placental insufficiency. Methods Placenta volumes were acquired using a portable ultrasound machine and a 3D ultrasound transducer and estimated using the Virtual Organ Computer-aided AnaLysis (VOCAL) image analysis software package. Intra-observer reliability and limits of agreement of the placenta volume measurements were calculated. Polynomial regression models for the mean and standard deviation as a function of gestational age for the placental volumes of uninfected women were created and tested. Based on these equations each measurement was converted into a z -score. The z-scores of the placental volumes of malaria infected and uninfected women were then compared. Results Eighty-four women (uninfected = 65; infected = 19) with a posterior placenta delivered congenitally normal, live born, single babies. The mean placental volumes in the uninfected women were modeled to fit 5th, 10th, 50th, 90th and 95th centiles for 14-24 weeks' gestation. Most placenta volumes in the infected women were below the 50th centile for gestational age; most of those with Plasmodium falciparum were below the 10th centile. The 95% intra-observer limits of agreement for first and second measurements were ± 37.0 mL and ± 25.4 mL at 30 degrees and 15 degrees rotation respectively. Conclusion The new technique of 3D ultrasound volumetry of the placenta may be useful to improve our understanding of the pathophysiological constraints on foetal growth caused by malaria infection in early pregnancy. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Pregnancy Three-dimensional ultrasound Placenta volume IUGR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Pregnancy Three-dimensional ultrasound Placenta volume IUGR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Rijken Marcus J Moroski William E Kiricharoen Suporn Karunkonkowit Noaeni Stevenson Gordon Ohuma Eric O Noble J Alison Kennedy Stephen H McGready Rose Papageorghiou Aris T Nosten François H Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
topic_facet |
Malaria Pregnancy Three-dimensional ultrasound Placenta volume IUGR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The presence of malaria parasites and histopathological changes in the placenta are associated with a reduction in birth weight, principally due to intrauterine growth restriction. The aim of this study was to examine the feasibility of studying early pregnancy placental volumes using three-dimensional (3D) ultrasound in a malaria endemic area, as a small volume in the second trimester may be an indicator of intra-uterine growth restriction and placental insufficiency. Methods Placenta volumes were acquired using a portable ultrasound machine and a 3D ultrasound transducer and estimated using the Virtual Organ Computer-aided AnaLysis (VOCAL) image analysis software package. Intra-observer reliability and limits of agreement of the placenta volume measurements were calculated. Polynomial regression models for the mean and standard deviation as a function of gestational age for the placental volumes of uninfected women were created and tested. Based on these equations each measurement was converted into a z -score. The z-scores of the placental volumes of malaria infected and uninfected women were then compared. Results Eighty-four women (uninfected = 65; infected = 19) with a posterior placenta delivered congenitally normal, live born, single babies. The mean placental volumes in the uninfected women were modeled to fit 5th, 10th, 50th, 90th and 95th centiles for 14-24 weeks' gestation. Most placenta volumes in the infected women were below the 50th centile for gestational age; most of those with Plasmodium falciparum were below the 10th centile. The 95% intra-observer limits of agreement for first and second measurements were ± 37.0 mL and ± 25.4 mL at 30 degrees and 15 degrees rotation respectively. Conclusion The new technique of 3D ultrasound volumetry of the placenta may be useful to improve our understanding of the pathophysiological constraints on foetal growth caused by malaria infection in early pregnancy. |
format |
Article in Journal/Newspaper |
author |
Rijken Marcus J Moroski William E Kiricharoen Suporn Karunkonkowit Noaeni Stevenson Gordon Ohuma Eric O Noble J Alison Kennedy Stephen H McGready Rose Papageorghiou Aris T Nosten François H |
author_facet |
Rijken Marcus J Moroski William E Kiricharoen Suporn Karunkonkowit Noaeni Stevenson Gordon Ohuma Eric O Noble J Alison Kennedy Stephen H McGready Rose Papageorghiou Aris T Nosten François H |
author_sort |
Rijken Marcus J |
title |
Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
title_short |
Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
title_full |
Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
title_fullStr |
Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
title_full_unstemmed |
Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
title_sort |
effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-5 https://doaj.org/article/0f764ad1e7b24cda9f6063ae6f21ed95 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 5 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/5 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-5 1475-2875 https://doaj.org/article/0f764ad1e7b24cda9f6063ae6f21ed95 |
op_doi |
https://doi.org/10.1186/1475-2875-11-5 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766345943391666176 |