Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial.
Antibiotic use on animals demonstrates improved growth regardless of whether or not there is clinical evidence of infectious disease. Antibiotics used for trachoma control may play an unintended benefit of improving child growth.In this sub-study of a larger randomized controlled trial, we assess an...
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ftdoajarticles:oai:doaj.org/article:0f633584638c450bb2c03f1a250a924d 2023-05-15T15:08:56+02:00 Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. Abdou Amza Sun N Yu Boubacar Kadri Baido Nassirou Nicole E Stoller Zhaoxia Zhou Sheila K West Robin L Bailey Bruce D Gaynor Jeremy D Keenan Travis C Porco Thomas M Lietman 2014-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003128 https://doaj.org/article/0f633584638c450bb2c03f1a250a924d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4161345?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003128 https://doaj.org/article/0f633584638c450bb2c03f1a250a924d PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3128 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003128 2022-12-31T14:05:48Z Antibiotic use on animals demonstrates improved growth regardless of whether or not there is clinical evidence of infectious disease. Antibiotics used for trachoma control may play an unintended benefit of improving child growth.In this sub-study of a larger randomized controlled trial, we assess anthropometry of pre-school children in a community-randomized trial of mass oral azithromycin distributions for trachoma in Niger. We measured height, weight, and mid-upper arm circumference (MUAC) in 12 communities randomized to receive annual mass azithromycin treatment of everyone versus 12 communities randomized to receive biannual mass azithromycin treatments for children, 3 years after the initial mass treatment. We collected measurements in 1,034 children aged 6-60 months of age.We found no difference in the prevalence of wasting among children in the 12 annually treated communities that received three mass azithromycin distributions compared to the 12 biannually treated communities that received six mass azithromycin distributions (odds ratio = 0.88, 95% confidence interval = 0.53 to 1.49).We were unable to demonstrate a statistically significant difference in stunting, underweight, and low MUAC of pre-school children in communities randomized to annual mass azithromycin treatment or biannual mass azithromycin treatment. The role of antibiotics on child growth and nutrition remains unclear, but larger studies and longitudinal trials may help determine any association. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 8 9 e3128 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Abdou Amza Sun N Yu Boubacar Kadri Baido Nassirou Nicole E Stoller Zhaoxia Zhou Sheila K West Robin L Bailey Bruce D Gaynor Jeremy D Keenan Travis C Porco Thomas M Lietman Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Antibiotic use on animals demonstrates improved growth regardless of whether or not there is clinical evidence of infectious disease. Antibiotics used for trachoma control may play an unintended benefit of improving child growth.In this sub-study of a larger randomized controlled trial, we assess anthropometry of pre-school children in a community-randomized trial of mass oral azithromycin distributions for trachoma in Niger. We measured height, weight, and mid-upper arm circumference (MUAC) in 12 communities randomized to receive annual mass azithromycin treatment of everyone versus 12 communities randomized to receive biannual mass azithromycin treatments for children, 3 years after the initial mass treatment. We collected measurements in 1,034 children aged 6-60 months of age.We found no difference in the prevalence of wasting among children in the 12 annually treated communities that received three mass azithromycin distributions compared to the 12 biannually treated communities that received six mass azithromycin distributions (odds ratio = 0.88, 95% confidence interval = 0.53 to 1.49).We were unable to demonstrate a statistically significant difference in stunting, underweight, and low MUAC of pre-school children in communities randomized to annual mass azithromycin treatment or biannual mass azithromycin treatment. The role of antibiotics on child growth and nutrition remains unclear, but larger studies and longitudinal trials may help determine any association. |
format |
Article in Journal/Newspaper |
author |
Abdou Amza Sun N Yu Boubacar Kadri Baido Nassirou Nicole E Stoller Zhaoxia Zhou Sheila K West Robin L Bailey Bruce D Gaynor Jeremy D Keenan Travis C Porco Thomas M Lietman |
author_facet |
Abdou Amza Sun N Yu Boubacar Kadri Baido Nassirou Nicole E Stoller Zhaoxia Zhou Sheila K West Robin L Bailey Bruce D Gaynor Jeremy D Keenan Travis C Porco Thomas M Lietman |
author_sort |
Abdou Amza |
title |
Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. |
title_short |
Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. |
title_full |
Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. |
title_fullStr |
Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. |
title_full_unstemmed |
Does mass azithromycin distribution impact child growth and nutrition in Niger? A cluster-randomized trial. |
title_sort |
does mass azithromycin distribution impact child growth and nutrition in niger? a cluster-randomized trial. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003128 https://doaj.org/article/0f633584638c450bb2c03f1a250a924d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3128 (2014) |
op_relation |
http://europepmc.org/articles/PMC4161345?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003128 https://doaj.org/article/0f633584638c450bb2c03f1a250a924d |
op_doi |
https://doi.org/10.1371/journal.pntd.0003128 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
9 |
container_start_page |
e3128 |
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1766340199804043264 |