C3435T Polymorphism of the ABCB1 gene in the Yakut Population
Background: The ABCB1 gene is responsible for resistance to various cytotoxic drugs. The product of the ABCB1 gene, P-glycoprotein (P-gp), acts as a transmembrane pump and influences the action of many drugs. More than 40 SNPs of the ABCB1 gene that alter the expression of P-gp have been identified....
Published in: | International Journal of Biomedicine |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
International Medical Research and Development Corporation
2021
|
Subjects: | |
Online Access: | https://doi.org/10.21103/Article11(3)_OA15 https://doaj.org/article/0f12b25b405c44a48861f88b288d20db |
id |
ftdoajarticles:oai:doaj.org/article:0f12b25b405c44a48861f88b288d20db |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:0f12b25b405c44a48861f88b288d20db 2023-05-15T18:45:14+02:00 C3435T Polymorphism of the ABCB1 gene in the Yakut Population Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Yigulana P. Borisova Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov 2021-09-01T00:00:00Z https://doi.org/10.21103/Article11(3)_OA15 https://doaj.org/article/0f12b25b405c44a48861f88b288d20db EN eng International Medical Research and Development Corporation http://ijbm.org/articles/i43/ijbm_11(3)_oa15.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article11(3)_OA15 2158-0510 2158-0529 https://doaj.org/article/0f12b25b405c44a48861f88b288d20db International Journal of Biomedicine, Vol 11, Iss 3, Pp 367-371 (2021) abcb1 snp multidrug resistance p-glycoprotein Medicine R article 2021 ftdoajarticles https://doi.org/10.21103/Article11(3)_OA15 2022-12-31T05:49:24Z Background: The ABCB1 gene is responsible for resistance to various cytotoxic drugs. The product of the ABCB1 gene, P-glycoprotein (P-gp), acts as a transmembrane pump and influences the action of many drugs. More than 40 SNPs of the ABCB1 gene that alter the expression of P-gp have been identified. The ABCB1 rs1045642 SNP, designated as C3435T (C-the wild-type allele, T-the variant allele), correlates with the activity of P-gp. The aim of our research was to study the distribution of alleles and genotypes of the ABCB1 C3435T polymorphism in Yakuts, in comparison with other human populations. Methods and Results: The studied cohort included 149 healthy Yakut volunteers (36 men and 113 women). The average age of participants was 30.67±0.06 years. The ABCB1 gene is a highly polymorphic gene; the allele frequency of the C3435T polymorphism differs widely among the studied populations. The frequency of the mutant T-allele among the Yakuts was 51% .In the studied group of Yakuts, we revealed the prevalence of the heterozygous CT genotype (75.8%). The Yakuts have a relatively low frequency of CC (10.7%) and TT (13.4%) genotypes. This preliminary study did not include the objective of proving the relationship between the ABCB1 C3435T polymorphism and addictive disorders in Yakuts. The further search for functional polymorphisms of the ABCB1 gene and associations with addictive behavior using a systematic approach on larger samples is of great practical importance. Article in Journal/Newspaper Yakuts Directory of Open Access Journals: DOAJ Articles International Journal of Biomedicine 11 3 367 371 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
abcb1 snp multidrug resistance p-glycoprotein Medicine R |
spellingShingle |
abcb1 snp multidrug resistance p-glycoprotein Medicine R Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Yigulana P. Borisova Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov C3435T Polymorphism of the ABCB1 gene in the Yakut Population |
topic_facet |
abcb1 snp multidrug resistance p-glycoprotein Medicine R |
description |
Background: The ABCB1 gene is responsible for resistance to various cytotoxic drugs. The product of the ABCB1 gene, P-glycoprotein (P-gp), acts as a transmembrane pump and influences the action of many drugs. More than 40 SNPs of the ABCB1 gene that alter the expression of P-gp have been identified. The ABCB1 rs1045642 SNP, designated as C3435T (C-the wild-type allele, T-the variant allele), correlates with the activity of P-gp. The aim of our research was to study the distribution of alleles and genotypes of the ABCB1 C3435T polymorphism in Yakuts, in comparison with other human populations. Methods and Results: The studied cohort included 149 healthy Yakut volunteers (36 men and 113 women). The average age of participants was 30.67±0.06 years. The ABCB1 gene is a highly polymorphic gene; the allele frequency of the C3435T polymorphism differs widely among the studied populations. The frequency of the mutant T-allele among the Yakuts was 51% .In the studied group of Yakuts, we revealed the prevalence of the heterozygous CT genotype (75.8%). The Yakuts have a relatively low frequency of CC (10.7%) and TT (13.4%) genotypes. This preliminary study did not include the objective of proving the relationship between the ABCB1 C3435T polymorphism and addictive disorders in Yakuts. The further search for functional polymorphisms of the ABCB1 gene and associations with addictive behavior using a systematic approach on larger samples is of great practical importance. |
format |
Article in Journal/Newspaper |
author |
Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Yigulana P. Borisova Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov |
author_facet |
Nadezhda I. Pavlova Aleksandra T. Diakonova Vladislav A. Alekseev Yigulana P. Borisova Vladimir V. Dodokhov Tuyara I. Dmitrieva Khariton A. Kurtanov |
author_sort |
Nadezhda I. Pavlova |
title |
C3435T Polymorphism of the ABCB1 gene in the Yakut Population |
title_short |
C3435T Polymorphism of the ABCB1 gene in the Yakut Population |
title_full |
C3435T Polymorphism of the ABCB1 gene in the Yakut Population |
title_fullStr |
C3435T Polymorphism of the ABCB1 gene in the Yakut Population |
title_full_unstemmed |
C3435T Polymorphism of the ABCB1 gene in the Yakut Population |
title_sort |
c3435t polymorphism of the abcb1 gene in the yakut population |
publisher |
International Medical Research and Development Corporation |
publishDate |
2021 |
url |
https://doi.org/10.21103/Article11(3)_OA15 https://doaj.org/article/0f12b25b405c44a48861f88b288d20db |
genre |
Yakuts |
genre_facet |
Yakuts |
op_source |
International Journal of Biomedicine, Vol 11, Iss 3, Pp 367-371 (2021) |
op_relation |
http://ijbm.org/articles/i43/ijbm_11(3)_oa15.pdf https://doaj.org/toc/2158-0510 https://doaj.org/toc/2158-0529 doi:10.21103/Article11(3)_OA15 2158-0510 2158-0529 https://doaj.org/article/0f12b25b405c44a48861f88b288d20db |
op_doi |
https://doi.org/10.21103/Article11(3)_OA15 |
container_title |
International Journal of Biomedicine |
container_volume |
11 |
container_issue |
3 |
container_start_page |
367 |
op_container_end_page |
371 |
_version_ |
1766236268079874048 |