(De)glutamylation and cell death in Leishmania parasites.
Trypanosomatids are flagellated protozoan parasites that are very unusual in terms of cytoskeleton organization but also in terms of cell death. Most of the Trypanosomatid cytoskeleton consists of microtubules, forming different substructures including a subpellicular corset. Oddly, the actin networ...
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ftdoajarticles:oai:doaj.org/article:0eff427a0f38431bad2d676718ccfd0f 2023-05-15T15:06:36+02:00 (De)glutamylation and cell death in Leishmania parasites. Louise Basmaciyan Derrick R Robinson Nadine Azas Magali Casanova 2019-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007264 https://doaj.org/article/0eff427a0f38431bad2d676718ccfd0f EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007264 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007264 https://doaj.org/article/0eff427a0f38431bad2d676718ccfd0f PLoS Neglected Tropical Diseases, Vol 13, Iss 4, p e0007264 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007264 2022-12-31T07:48:36Z Trypanosomatids are flagellated protozoan parasites that are very unusual in terms of cytoskeleton organization but also in terms of cell death. Most of the Trypanosomatid cytoskeleton consists of microtubules, forming different substructures including a subpellicular corset. Oddly, the actin network appears structurally and functionally different from other eukaryotic actins. And Trypanosomatids have an apoptotic phenotype under cell death conditions, but the pathways involved are devoid of key mammal proteins such as caspases or death receptors, and the triggers involved in apoptotic induction remain unknown. In this article, we have studied the role of the post-translational modifications, deglutamylation and polyglutamylation, in Leishmania. We have shown that Leishmania apoptosis was linked to polyglutamylation and hypothesized that the cell survival process autophagy was linked to deglutamylation. A balance seems to be established between polyglutamylation and deglutamylation, with imbalance inducing microtubule or other protein modifications characterizing either cell death if polyglutamylation was prioritized, or the cell survival process of autophagy if deglutamylation was prioritized. This emphasizes the role of post-translational modifications in cell biology, inducing cell death or cell survival of infectious agents. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 4 e0007264 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Louise Basmaciyan Derrick R Robinson Nadine Azas Magali Casanova (De)glutamylation and cell death in Leishmania parasites. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Trypanosomatids are flagellated protozoan parasites that are very unusual in terms of cytoskeleton organization but also in terms of cell death. Most of the Trypanosomatid cytoskeleton consists of microtubules, forming different substructures including a subpellicular corset. Oddly, the actin network appears structurally and functionally different from other eukaryotic actins. And Trypanosomatids have an apoptotic phenotype under cell death conditions, but the pathways involved are devoid of key mammal proteins such as caspases or death receptors, and the triggers involved in apoptotic induction remain unknown. In this article, we have studied the role of the post-translational modifications, deglutamylation and polyglutamylation, in Leishmania. We have shown that Leishmania apoptosis was linked to polyglutamylation and hypothesized that the cell survival process autophagy was linked to deglutamylation. A balance seems to be established between polyglutamylation and deglutamylation, with imbalance inducing microtubule or other protein modifications characterizing either cell death if polyglutamylation was prioritized, or the cell survival process of autophagy if deglutamylation was prioritized. This emphasizes the role of post-translational modifications in cell biology, inducing cell death or cell survival of infectious agents. |
format |
Article in Journal/Newspaper |
author |
Louise Basmaciyan Derrick R Robinson Nadine Azas Magali Casanova |
author_facet |
Louise Basmaciyan Derrick R Robinson Nadine Azas Magali Casanova |
author_sort |
Louise Basmaciyan |
title |
(De)glutamylation and cell death in Leishmania parasites. |
title_short |
(De)glutamylation and cell death in Leishmania parasites. |
title_full |
(De)glutamylation and cell death in Leishmania parasites. |
title_fullStr |
(De)glutamylation and cell death in Leishmania parasites. |
title_full_unstemmed |
(De)glutamylation and cell death in Leishmania parasites. |
title_sort |
(de)glutamylation and cell death in leishmania parasites. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007264 https://doaj.org/article/0eff427a0f38431bad2d676718ccfd0f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 4, p e0007264 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007264 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007264 https://doaj.org/article/0eff427a0f38431bad2d676718ccfd0f |
op_doi |
https://doi.org/10.1371/journal.pntd.0007264 |
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PLOS Neglected Tropical Diseases |
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13 |
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4 |
container_start_page |
e0007264 |
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1766338172065677312 |